Details for: Igfbp3

Gene ID: 16009

Symbol: Igfbp3

Ensembl ID: ENSMUSG00000020427

Description: insulin-like growth factor binding protein 3

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Metabolism of proteins
    (R-MMU-392499)
  • Post-translational protein modification
    (R-MMU-597592)
  • Post-translational protein phosphorylation
    (R-MMU-8957275)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-MMU-381426)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Tp53 regulates transcription of cell death genes
    (R-MMU-5633008)
  • Tp53 regulates transcription of death receptors and ligands
    (R-MMU-6803211)
  • Transcriptional regulation by tp53
    (R-MMU-3700989)
  • Apoptotic process
    (GO:0006915)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibronectin binding
    (GO:0001968)
  • Growth factor binding
    (GO:0019838)
  • Heterochromatin
    (GO:0000792)
  • Insulin-like growth factor binary complex
    (GO:0042568)
  • Insulin-like growth factor binding
    (GO:0005520)
  • Insulin-like growth factor i binding
    (GO:0031994)
  • Insulin-like growth factor ii binding
    (GO:0031995)
  • Insulin-like growth factor ternary complex
    (GO:0042567)
  • Mapk cascade
    (GO:0000165)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of protein phosphorylation
    (GO:0001933)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of testosterone secretion
    (GO:2000844)
  • Nucleus
    (GO:0005634)
  • Osteoblast differentiation
    (GO:0001649)
  • Platelet alpha granule
    (GO:0031091)
  • Positive regulation of apoptotic dna fragmentation
    (GO:1902512)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cardiac muscle cell apoptotic process
    (GO:0010666)
  • Positive regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043568)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of myoblast differentiation
    (GO:0045663)
  • Protein phosphorylation
    (GO:0006468)
  • Protein tyrosine phosphatase activator activity
    (GO:0008160)
  • Regulation of cell growth
    (GO:0001558)
  • Regulation of glucose metabolic process
    (GO:0010906)
  • Regulation of growth
    (GO:0040008)
  • Regulation of insulin-like growth factor receptor signaling pathway
    (GO:0043567)
  • Type b pancreatic cell proliferation
    (GO:0044342)

Other Information

Genular Protein ID: 467760178

Symbol: IBP3_MOUSE

Name: Insulin-like growth factor-binding protein 3

UniProtKB Accession Codes:

P47878 Q6PE62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 DNASU 1 EMBL 3 Ensembl 2 GO 30 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MEROPS 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7529732

Title: cDNA cloning and mRNA expression of the six mouse insulin-like growth factor binding proteins.

PubMed ID: 7529732

DOI: 10.1016/0303-7207(94)90051-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19952275

Title: Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis.

PubMed ID: 19952275

DOI: 10.1210/en.2009-0577

Sequence Information:

  • Length: 292
  • Mass: 31687
  • Checksum: 317F830AA843B73D
  • Sequence:
    • MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALSQ CAPPPTAPAC 
TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP AEQYPLRALL NGRGFCANAS 
AAGSLSTYLP SQPAPGNISE SEEEHNAGSV ESQVVPSTHR VTDSKFHPLH AKMDVIKKGH 
ARDSQRYKVD YESQSTDTQN FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN 
CDKKGFYKKK QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ

Genular Protein ID: 486147167

Symbol: Q3UR87_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UR87

Database IDs:

AGR 1 ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 InterPro 6 KEGG 1 MEROPS 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 5 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 2

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 210
  • Mass: 23528
  • Checksum: 1E0D86F28FDCD536
  • Sequence:
    • CGVYTERCGT GLRCQPRPAE QYPLRALLNG RGFCANASAA GSLSTYLPSQ PAPGNISESE 
EEHNAGSVES QVVPSTHRVT DSKFHPLHAK MDVIKKGHAR DSQRYKVDYE SQSTDTQNFS 
SESKRETEYG PCRREMEDTL NHLKFLNVLS PRGVHIPNCD KKGFYKKKQC RPSKGRKRGF 
CWCVDKYGQP LPGYDTKGKD DVHCLSVQSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.