Gene AP2A2 - ENSG00000183020 | NCBI Gene ID: 161

Details for: AP2A2

Gene ID: 161

Symbol: AP2A2

Ensembl ID: ENSG00000183020

Description: adaptor related protein complex 2 subunit alpha 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Ldl clearance
(R-HSA-8964038)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Nef mediated cd8 down-regulation
(R-HSA-182218)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neutrophil degranulation
(R-HSA-6798695)
Pcp/ce pathway
(R-HSA-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Potential therapeutics for sars
(R-HSA-9679191)
Recycling pathway of l1
(R-HSA-437239)
Retrograde neurotrophin signalling
(R-HSA-177504)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Vldlr internalisation and degradation
(R-HSA-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-HSA-5140745)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Ap-2 adaptor complex
(GO:0030122)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Endocytic vesicle membrane
(GO:0030666)
Endolysosome membrane
(GO:0036020)
Ficolin-1-rich granule membrane
(GO:0101003)
Intracellular protein transport
(GO:0006886)
Lipid binding
(GO:0008289)
Molecular_function
(GO:0003674)
Plasma membrane
(GO:0005886)
Postsynapse
(GO:0098794)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Secretory granule membrane
(GO:0030667)
Vesicle-mediated transport
(GO:0016192)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.41
Marker Score: 1410
Cell Name: germ cell (CL0000586)
Fold Change: 2.39
Marker Score: 4170
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.05
Marker Score: 2757
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.02
Marker Score: 30166.5
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.84
Marker Score: 70046.5
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.84
Marker Score: 2225
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8
Marker Score: 110980.5
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.8
Marker Score: 35865
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.79
Marker Score: 1377
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.77
Marker Score: 4349
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.76
Marker Score: 16552.5
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.76
Marker Score: 64791.5
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.75
Marker Score: 18088
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.75
Marker Score: 16583.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.74
Marker Score: 1742
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.73
Marker Score: 6671
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.71
Marker Score: 13096
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.7
Marker Score: 1826
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.7
Marker Score: 14601.5
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.69
Marker Score: 1351
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.67
Marker Score: 6906
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.66
Marker Score: 1836
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.58
Marker Score: 6595.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.5
Marker Score: 828
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.48
Marker Score: 3475
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.47
Marker Score: 859
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.47
Marker Score: 876
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.46
Marker Score: 2260
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.44
Marker Score: 2934
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.44
Marker Score: 30709.5
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.44
Marker Score: 5105
Cell Name: lens fiber cell (CL0011004)
Fold Change: 1.41
Marker Score: 445
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.39
Marker Score: 1587
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.38
Marker Score: 1590
Cell Name: neuron (CL0000540)
Fold Change: 1.38
Marker Score: 5619.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.37
Marker Score: 1453
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.35
Marker Score: 3624
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.34
Marker Score: 1443
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.34
Marker Score: 1156
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.31
Marker Score: 6048
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.3
Marker Score: 2498
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.29
Marker Score: 3264
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.29
Marker Score: 2823
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.27
Marker Score: 298
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.27
Marker Score: 711
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.25
Marker Score: 1507
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.2
Marker Score: 1352
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.2
Marker Score: 1133
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.2
Marker Score: 1247
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.19
Marker Score: 356
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.19
Marker Score: 414
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.19
Marker Score: 1204
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.19
Marker Score: 497
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.17
Marker Score: 1654.5
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.17
Marker Score: 6126
Cell Name: lactocyte (CL0002325)
Fold Change: 1.15
Marker Score: 18410
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.14
Marker Score: 1197
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.13
Marker Score: 1200
Cell Name: acinar cell (CL0000622)
Fold Change: 1.13
Marker Score: 800
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.13
Marker Score: 422
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.12
Marker Score: 1877
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.11
Marker Score: 646
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.11
Marker Score: 1561
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.1
Marker Score: 1332
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.1
Marker Score: 545
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.1
Marker Score: 1603
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.1
Marker Score: 1583
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.09
Marker Score: 1038
Cell Name: keratocyte (CL0002363)
Fold Change: 1.09
Marker Score: 250
Cell Name: kidney cell (CL1000497)
Fold Change: 1.08
Marker Score: 723
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.07
Marker Score: 260
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.06
Marker Score: 336
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.06
Marker Score: 332
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.06
Marker Score: 704
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.05
Marker Score: 36292
Cell Name: podocyte (CL0000653)
Fold Change: 1.03
Marker Score: 382
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.03
Marker Score: 2933
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.02
Marker Score: 639
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.02
Marker Score: 496
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.01
Marker Score: 3965
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.01
Marker Score: 924
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.01
Marker Score: 2290
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1
Marker Score: 323
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1
Marker Score: 526
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71640
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Marker Score: 47864.5
Cell Name: basal cell (CL0000646)
Fold Change: 0.99
Marker Score: 1279
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.99
Marker Score: 4254
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30378
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.98
Marker Score: 1228.5
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.98
Marker Score: 876
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.97
Marker Score: 661
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.96
Marker Score: 910
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.96
Marker Score: 349
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.96
Marker Score: 6171
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.96
Marker Score: 261
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.95
Marker Score: 572
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.94
Marker Score: 1141
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.94
Marker Score: 3498
Cell Name: astrocyte (CL0000127)
Fold Change: 0.94
Marker Score: 816

Hover over a box to see details here...

**Key characteristics:** * AP2A2 is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the AP2A family of proteins, which are involved in the regulation of cell adhesion, migration, and differentiation. * AP2A2 is a key regulator of B cell development and function. * It is also involved in the regulation of dendritic cell function. **Pathways and functions:** * AP2A2 is involved in the regulation of B cell development and function. * It is a key regulator of the transition of naive B cells to plasma cells. * It is also involved in the regulation of B cell activation and differentiation. * AP2A2 is also involved in the regulation of dendritic cell function. * It is a key regulator of the maturation and function of dendritic cells. * It is involved in the regulation of the adaptive immune response. **Clinical significance:** * Mutations in AP2A2 have been linked to a number of human diseases, including autoimmune disorders, cancer, and neurodegenerative disorders. * AP2A2 is a potential target for the treatment of these diseases. * Studies of AP2A2 have led to the development of new diagnostic and therapeutic tools for these diseases. **Additional notes:** * AP2A2 is a highly conserved protein. * It is expressed in high levels in the brain and other tissues with a high density of immune cells. * It is a key regulator of the adaptive immune response.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AP-2 complex subunit alpha-2

Genular Protein ID: 2341473117

Symbol: AP2A2_HUMAN

Name: AP-2 complex subunit alpha-2

UniProtKB Accession Codes:

O94973 O75403 Q53ET1 Q96SI8

Database IDs:

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700202

Title: Huntingtin interacts with a family of WW domain proteins.

PubMed ID: 9700202

DOI: 10.1093/hmg/7.9.1463

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 12960147

Title: Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells.

PubMed ID: 12960147

DOI: 10.1074/jbc.m307290200

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 15598649

Title: AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

PubMed ID: 15598649

DOI: 10.1074/jbc.m411862200

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22262466

Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

PubMed ID: 22262466

DOI: 10.1002/hep.25591

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 24097348

Title: alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits.

PubMed ID: 24097348

DOI: 10.1038/nature12571

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

Sequence Information:

Length: 939
Mass: 103960
Checksum: A8D3CC1B15B8C6BF
Sequence:

MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC 
KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL 
ASRNPTFMGL ALHCIASVGS REMAEAFAGE IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP 
DLVPMGDWTS RVVHLLNDQH LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA 
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ 
HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE SMCTLASSEF 
SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN APQIVAEMLS YLETADYSIR 
EEIVLKVAIL AEKYAVDYTW YVDTILNLIR IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK 
TVFEALQAPA CHENLVKVGG YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL 
LSTYIKFVNL FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE 
MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS AVSTPSPSAD 
LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP GSEDNFARFV CKNNGVLFEN 
QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG 
GAQVQQVVNI ECVSDFTEAP VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR 
WKQLSNPQQE VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ 
IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: AP2A2

Associated with

Cells (max top 100)

Other Information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Huntingtin interacts with a family of WW domain proteins. PubMed ID: 9700202

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. PubMed ID: 11532990

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. PubMed ID: 14745134

Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. PubMed ID: 12960147

Adaptors for clathrin coats: structure and function. PubMed ID: 15473838

AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif. PubMed ID: 15598649

The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. PubMed ID: 19033387

Initial characterization of the human central proteome. PubMed ID: 21269460

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. PubMed ID: 22262466

Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. PubMed ID: 22484487

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits. PubMed ID: 24097348

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development. PubMed ID: 29262337