AP2A2 | ENSG00000183020 | NCBI 161

Details for: AP2A2

Gene ID: 161

Symbol: AP2A2

Ensembl ID: ENSG00000183020

Description: adaptor related protein complex 2 subunit alpha 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Ldl clearance
(R-HSA-8964038)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Nef mediated cd8 down-regulation
(R-HSA-182218)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neutrophil degranulation
(R-HSA-6798695)
Pcp/ce pathway
(R-HSA-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Potential therapeutics for sars
(R-HSA-9679191)
Recycling pathway of l1
(R-HSA-437239)
Retrograde neurotrophin signalling
(R-HSA-177504)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Vldlr internalisation and degradation
(R-HSA-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-HSA-5140745)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Ap-2 adaptor complex
(GO:0030122)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Endocytic vesicle membrane
(GO:0030666)
Endolysosome membrane
(GO:0036020)
Ficolin-1-rich granule membrane
(GO:0101003)
Intracellular protein transport
(GO:0006886)
Lipid binding
(GO:0008289)
Molecular_function
(GO:0003674)
Plasma membrane
(GO:0005886)
Postsynapse
(GO:0098794)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Presynapse
(GO:0098793)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Secretory granule membrane
(GO:0030667)
Synaptic vesicle endocytosis
(GO:0048488)
Vesicle-mediated transport
(GO:0016192)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1
Cell Significance Index: 1
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1
Cell Significance Index: 1
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 1
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 1
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 1
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 1
Cell Significance Index: 1
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1
Cell Significance Index: 1
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: chondroblast (CL0000058)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: muscle fibroblast (CL1001609)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: enterocyte (CL0000584)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: supporting cell (CL0000630)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: stem cell (CL0000034)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast (CL0000057)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: melanocyte (CL0000148)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: OFF-bipolar cell (CL0000750)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: centroblast (CL0009112)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: granular cell of epidermis (CL0002189)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: endocardial cell (CL0002350)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: macrophage (CL0000235)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: basal cell (CL0000646)
Fold Change: 0.99
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** AP2A2 is a subunit of the adaptor protein complex 2 (AP-2), which is a conserved family of adaptor proteins involved in various cellular processes, including endocytosis, signaling, and transcription regulation. AP2A2 is specifically characterized by its ability to bind to and regulate the activity of various signaling molecules, including Wnt proteins, Eph receptors, and receptor tyrosine kinases. Its distinct domain structure, comprising a cytoplasmic and transmembrane domain, allows for its interaction with multiple cellular components. **Pathways and Functions:** AP2A2 is involved in numerous cellular pathways, including: 1. **Adaptive Immune System:** AP2A2 plays a crucial role in the adaptive immune response by regulating the activity of MHC class II molecules and influencing the presentation of antigens to T-cells. 2. **Axon Guidance:** AP2A2 is involved in axon guidance and neuronal development, regulating the trafficking of synaptic receptors and neurotransmitters. 3. **Clathrin-Mediated Endocytosis:** AP2A2 is a key component of the clathrin-coated endocytic vesicle, facilitating the internalization of receptors, ligands, and other cellular components. 4. **Cargo Recognition for Clathrin-Mediated Endocytosis:** AP2A2 recognizes and binds to specific cargo molecules, facilitating their internalization and regulation of cellular signaling. **Clinical Significance:** The involvement of AP2A2 in various diseases highlights its clinical significance: 1. **HIV-1 Replication:** AP2A2 is a target for HIV-1 Nef, a viral protein that down-regulates cell surface receptors, facilitating viral entry and replication. 2. **SARS-CoV Infections:** AP2A2 is involved in the regulation of SARS-CoV entry and replication, highlighting its potential as a therapeutic target. 3. **Immune System Dysregulation:** AP2A2 dysregulation has been implicated in various immune-related disorders, including multiple sclerosis and rheumatoid arthritis. 4. **Cancer:** AP2A2 has been identified as a potential biomarker for cancer diagnosis and prognosis, with its expression altered in various tumor types. In conclusion, AP2A2 is a multifaceted gene involved in various cellular processes, including immune regulation, axon guidance, and disease pathogenesis. Its clinical significance underscores the importance of understanding its role in human health and disease, with potential therapeutic applications in the treatment of various diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.