AP2A2 | ENSG00000183020 | NCBI 161

Details for: AP2A2

Gene ID: 161

Symbol: AP2A2

Ensembl ID: ENSG00000183020

Description: adaptor related protein complex 2 subunit alpha 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Hiv infection
(R-HSA-162906)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
L1cam interactions
(R-HSA-373760)
Ldl clearance
(R-HSA-8964038)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
(R-HSA-164938)
Nef mediated cd4 down-regulation
(R-HSA-167590)
Nef mediated cd8 down-regulation
(R-HSA-182218)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Neutrophil degranulation
(R-HSA-6798695)
Pcp/ce pathway
(R-HSA-4086400)
Plasma lipoprotein assembly, remodeling, and clearance
(R-HSA-174824)
Plasma lipoprotein clearance
(R-HSA-8964043)
Potential therapeutics for sars
(R-HSA-9679191)
Recycling pathway of l1
(R-HSA-437239)
Retrograde neurotrophin signalling
(R-HSA-177504)
Sars-cov infections
(R-HSA-9679506)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
The role of nef in hiv-1 replication and disease pathogenesis
(R-HSA-164952)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport of small molecules
(R-HSA-382551)
Viral infection pathways
(R-HSA-9824446)
Vldlr internalisation and degradation
(R-HSA-8866427)
Wnt5a-dependent internalization of fzd2, fzd5 and ror2
(R-HSA-5140745)
Wnt5a-dependent internalization of fzd4
(R-HSA-5099900)
Ap-2 adaptor complex
(GO:0030122)
Clathrin-coated endocytic vesicle
(GO:0045334)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Clathrin-dependent endocytosis
(GO:0072583)
Clathrin adaptor activity
(GO:0035615)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Endocytic vesicle membrane
(GO:0030666)
Endolysosome membrane
(GO:0036020)
Ficolin-1-rich granule membrane
(GO:0101003)
Intracellular protein transport
(GO:0006886)
Lipid binding
(GO:0008289)
Molecular_function
(GO:0003674)
Plasma membrane
(GO:0005886)
Postsynapse
(GO:0098794)
Postsynaptic neurotransmitter receptor internalization
(GO:0098884)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Secretory granule membrane
(GO:0030667)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

AP-2 complex subunit alpha-2

Genular Protein ID: 2341473117

Symbol: AP2A2_HUMAN

Name: AP-2 complex subunit alpha-2

UniProtKB Accession Codes:

O94973 O75403 Q53ET1 Q96SI8

Database IDs:

Citations:

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700202

Title: Huntingtin interacts with a family of WW domain proteins.

PubMed ID: 9700202

DOI: 10.1093/hmg/7.9.1463

PubMed ID: 11532990

Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.

PubMed ID: 11532990

DOI: 10.1093/hmg/10.17.1807

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 12960147

Title: Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells.

PubMed ID: 12960147

DOI: 10.1074/jbc.m307290200

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 15598649

Title: AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

PubMed ID: 15598649

DOI: 10.1074/jbc.m411862200

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22262466

Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.

PubMed ID: 22262466

DOI: 10.1002/hep.25591

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 24097348

Title: alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits.

PubMed ID: 24097348

DOI: 10.1038/nature12571

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

Sequence Information:

Length: 939
Mass: 103960
Checksum: A8D3CC1B15B8C6BF
Sequence:

MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC 
KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL 
ASRNPTFMGL ALHCIASVGS REMAEAFAGE IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP 
DLVPMGDWTS RVVHLLNDQH LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA 
STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ 
HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE SMCTLASSEF 
SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN APQIVAEMLS YLETADYSIR 
EEIVLKVAIL AEKYAVDYTW YVDTILNLIR IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK 
TVFEALQAPA CHENLVKVGG YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL 
LSTYIKFVNL FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE 
MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS AVSTPSPSAD 
LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP GSEDNFARFV CKNNGVLFEN 
QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG 
GAQVQQVVNI ECVSDFTEAP VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR 
WKQLSNPQQE VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ 
IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AP2A2

Associated with

Other Information

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10048485

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Huntingtin interacts with a family of WW domain proteins. PubMed ID: 9700202

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis. PubMed ID: 11532990

Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. PubMed ID: 14745134

Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. PubMed ID: 12960147

Adaptors for clathrin coats: structure and function. PubMed ID: 15473838

AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif. PubMed ID: 15598649

The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway. PubMed ID: 19033387

Initial characterization of the human central proteome. PubMed ID: 21269460

AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function. PubMed ID: 22262466

Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. PubMed ID: 22484487

Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. PubMed ID: 23676497

alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits. PubMed ID: 24097348

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development. PubMed ID: 29262337