Details for: AP2A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 318.2997
Cell Significance Index: -49.5100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 199.0196
Cell Significance Index: -50.4800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 117.0882
Cell Significance Index: -55.2800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 114.1888
Cell Significance Index: -46.3900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 100.1973
Cell Significance Index: -51.5400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 48.8927
Cell Significance Index: -46.6800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.4695
Cell Significance Index: -51.1300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.2097
Cell Significance Index: -51.4600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.9375
Cell Significance Index: -45.8800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.2563
Cell Significance Index: -52.3100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.2610
Cell Significance Index: -18.0800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 3.1910
Cell Significance Index: 79.5800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0515
Cell Significance Index: 411.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8690
Cell Significance Index: 370.9000 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.5019
Cell Significance Index: 24.1000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.4066
Cell Significance Index: 11.4700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.2521
Cell Significance Index: 449.1200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2286
Cell Significance Index: 121.5400 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0227
Cell Significance Index: 111.2400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.9695
Cell Significance Index: 14.3100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9250
Cell Significance Index: 41.9300 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8823
Cell Significance Index: 52.9700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7899
Cell Significance Index: 128.4700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7871
Cell Significance Index: 49.6100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7462
Cell Significance Index: 134.5200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6916
Cell Significance Index: 26.1900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6651
Cell Significance Index: 29.4200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6406
Cell Significance Index: 7.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5941
Cell Significance Index: 12.8700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5668
Cell Significance Index: 392.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5648
Cell Significance Index: 308.4400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5367
Cell Significance Index: 15.0000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4875
Cell Significance Index: 33.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4682
Cell Significance Index: 64.3000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4594
Cell Significance Index: 56.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3268
Cell Significance Index: 25.0800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3007
Cell Significance Index: 15.7900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2992
Cell Significance Index: 13.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.2911
Cell Significance Index: 395.8700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.2835
Cell Significance Index: 3.3800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2175
Cell Significance Index: 196.4200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1919
Cell Significance Index: 10.7700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1838
Cell Significance Index: 3.1500 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.1586
Cell Significance Index: 70.1100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1510
Cell Significance Index: 232.4500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1473
Cell Significance Index: 271.6200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1399
Cell Significance Index: 263.5100 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1067
Cell Significance Index: 13.6800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0639
Cell Significance Index: 3.3300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0524
Cell Significance Index: 1.8400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0504
Cell Significance Index: 9.5900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0476
Cell Significance Index: 8.1200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0368
Cell Significance Index: 1.9100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0257
Cell Significance Index: 11.6500 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0187
Cell Significance Index: 11.8700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0082
Cell Significance Index: 0.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0050
Cell Significance Index: 3.6500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0172
Cell Significance Index: -12.7500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0182
Cell Significance Index: -11.3700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0374
Cell Significance Index: -0.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0390
Cell Significance Index: -29.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0394
Cell Significance Index: -1.1400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0600
Cell Significance Index: -33.8200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0702
Cell Significance Index: -7.1700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1264
Cell Significance Index: -26.6200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1331
Cell Significance Index: -17.2000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1594
Cell Significance Index: -45.8600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1599
Cell Significance Index: -7.5200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1609
Cell Significance Index: -8.1300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1691
Cell Significance Index: -19.7100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1729
Cell Significance Index: -11.1600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1731
Cell Significance Index: -25.1600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1764
Cell Significance Index: -20.2100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2251
Cell Significance Index: -26.5500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2313
Cell Significance Index: -17.2400 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3708
Cell Significance Index: -6.2100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3879
Cell Significance Index: -40.3900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3918
Cell Significance Index: -27.7100 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.4713
Cell Significance Index: -6.4300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4763
Cell Significance Index: -6.8500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4852
Cell Significance Index: -55.3800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4934
Cell Significance Index: -39.0800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.5013
Cell Significance Index: -12.5300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.5319
Cell Significance Index: -7.9700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.5776
Cell Significance Index: -3.4900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.6615
Cell Significance Index: -17.7000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6813
Cell Significance Index: -14.5100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.7028
Cell Significance Index: -7.2800 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7084
Cell Significance Index: -22.6900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7292
Cell Significance Index: -25.3400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7306
Cell Significance Index: -18.7800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7350
Cell Significance Index: -23.4100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7599
Cell Significance Index: -16.6400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7627
Cell Significance Index: -24.9700 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.7666
Cell Significance Index: -16.2700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.7729
Cell Significance Index: -13.0200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7805
Cell Significance Index: -47.8500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7889
Cell Significance Index: -7.2700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8193
Cell Significance Index: -22.3000 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8705
Cell Significance Index: -25.6400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2341473117
Symbol: AP2A2_HUMAN
Name: 100 kDa coated vesicle protein C
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10048485
Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
PubMed ID: 10048485
PubMed ID: 12168954
Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
PubMed ID: 12168954
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9700202
Title: Huntingtin interacts with a family of WW domain proteins.
PubMed ID: 9700202
DOI: 10.1093/hmg/7.9.1463
PubMed ID: 11532990
Title: The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis.
PubMed ID: 11532990
PubMed ID: 14745134
Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.
PubMed ID: 14745134
DOI: 10.1247/csf.28.419
PubMed ID: 12960147
Title: Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells.
PubMed ID: 12960147
PubMed ID: 15473838
Title: Adaptors for clathrin coats: structure and function.
PubMed ID: 15473838
PubMed ID: 15598649
Title: AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.
PubMed ID: 15598649
PubMed ID: 19033387
Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.
PubMed ID: 19033387
DOI: 10.1242/jcs.033522
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22262466
Title: AP2 adaptor complex mediates bile salt export pump internalization and modulates its hepatocanalicular expression and transport function.
PubMed ID: 22262466
DOI: 10.1002/hep.25591
PubMed ID: 22484487
Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
PubMed ID: 22484487
DOI: 10.1038/ncb2473
PubMed ID: 23676497
Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.
PubMed ID: 23676497
DOI: 10.1172/jci65401
PubMed ID: 24097348
Title: alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits.
PubMed ID: 24097348
DOI: 10.1038/nature12571
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29262337
Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.
PubMed ID: 29262337
Sequence Information:
- Length: 939
- Mass: 103960
- Checksum: A8D3CC1B15B8C6BF
- Sequence:
MPAVSKGDGM RGLAVFISDI RNCKSKEAEI KRINKELANI RSKFKGDKAL DGYSKKKYVC KLLFIFLLGH DIDFGHMEAV NLLSSNRYTE KQIGYLFISV LVNSNSELIR LINNAIKNDL ASRNPTFMGL ALHCIASVGS REMAEAFAGE IPKVLVAGDT MDSVKQSAAL CLLRLYRTSP DLVPMGDWTS RVVHLLNDQH LGVVTAATSL ITTLAQKNPE EFKTSVSLAV SRLSRIVTSA STDLQDYTYY FVPAPWLSVK LLRLLQCYPP PDPAVRGRLT ECLETILNKA QEPPKSKKVQ HSNAKNAVLF EAISLIIHHD SEPNLLVRAC NQLGQFLQHR ETNLRYLALE SMCTLASSEF SHEAVKTHIE TVINALKTER DVSVRQRAVD LLYAMCDRSN APQIVAEMLS YLETADYSIR EEIVLKVAIL AEKYAVDYTW YVDTILNLIR IAGDYVSEEV WYRVIQIVIN RDDVQGYAAK TVFEALQAPA CHENLVKVGG YILGEFGNLI AGDPRSSPLI QFHLLHSKFH LCSVPTRALL LSTYIKFVNL FPEVKPTIQD VLRSDSQLRN ADVELQQRAV EYLRLSTVAS TDILATVLEE MPPFPERESS ILAKLKKKKG PSTVTDLEDT KRDRSVDVNG GPEPAPASTS AVSTPSPSAD LLGLGAAPPA PAGPPPSSGG SGLLVDVFSD SASVVAPLAP GSEDNFARFV CKNNGVLFEN QLLQIGLKSE FRQNLGRMFI FYGNKTSTQF LNFTPTLICS DDLQPNLNLQ TKPVDPTVEG GAQVQQVVNI ECVSDFTEAP VLNIQFRYGG TFQNVSVQLP ITLNKFFQPT EMASQDFFQR WKQLSNPQQE VQNIFKAKHP MDTEVTKAKI IGFGSALLEE VDPNPANFVG AGIIHTKTTQ IGCLLRLEPN LQAQMYRLTL RTSKEAVSQR LCELLSAQF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.