Details for: DAP

Gene ID: 1611

Symbol: DAP

Ensembl ID: ENSG00000112977

Description: death associated protein

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Apoptotic process
    (GO:0006915)
  • Apoptotic signaling pathway
    (GO:0097190)
  • Autophagy
    (GO:0006914)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Death domain binding
    (GO:0070513)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Regulation of translation
    (GO:0006417)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.06
    Marker Score: 2771
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.03
    Marker Score: 4622
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.87
    Marker Score: 2748
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.78
    Marker Score: 2862
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.76
    Marker Score: 3712
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.63
    Marker Score: 2703
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.6
    Marker Score: 645
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.55
    Marker Score: 651
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.53
    Marker Score: 4109.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.53
    Marker Score: 1585
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.51
    Marker Score: 3423
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.51
    Marker Score: 1822
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.5
    Marker Score: 598
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.49
    Marker Score: 787
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.48
    Marker Score: 859
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.47
    Marker Score: 986
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.42
    Marker Score: 1499
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.41
    Marker Score: 8976
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.39
    Marker Score: 1479
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.39
    Marker Score: 6680
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.38
    Marker Score: 683
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.38
    Marker Score: 1895
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.38
    Marker Score: 3471
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.37
    Marker Score: 309
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.34
    Marker Score: 799
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.34
    Marker Score: 466
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.32
    Marker Score: 373
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.3
    Marker Score: 1246
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.3
    Marker Score: 6811
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.29
    Marker Score: 5082
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.27
    Marker Score: 475
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.27
    Marker Score: 698
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.27
    Marker Score: 591
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.26
    Marker Score: 3433
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1269
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.25
    Marker Score: 2182
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.24
    Marker Score: 4414
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.23
    Marker Score: 840
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.22
    Marker Score: 12339
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.21
    Marker Score: 1301
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.2
    Marker Score: 7846
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.19
    Marker Score: 938
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.19
    Marker Score: 302
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.18
    Marker Score: 342
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.18
    Marker Score: 1875
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.18
    Marker Score: 818
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.17
    Marker Score: 2331
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.16
    Marker Score: 367
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.15
    Marker Score: 1058
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.15
    Marker Score: 592
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.15
    Marker Score: 2998
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.14
    Marker Score: 395
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7432
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Marker Score: 17827
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.11
    Marker Score: 224
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.11
    Marker Score: 4275
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.1
    Marker Score: 762
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.09
    Marker Score: 689
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 269
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.09
    Marker Score: 541
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.09
    Marker Score: 1675
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.09
    Marker Score: 406
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.08
    Marker Score: 491
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.08
    Marker Score: 2550
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.08
    Marker Score: 3539
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.07
    Marker Score: 2549
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.06
    Marker Score: 1415
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.06
    Marker Score: 342.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.06
    Marker Score: 444
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.06
    Marker Score: 818
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2152
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.05
    Marker Score: 1791
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.05
    Marker Score: 3898
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.05
    Marker Score: 2196
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.05
    Marker Score: 251
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.05
    Marker Score: 716
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.04
    Marker Score: 4043
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.04
    Marker Score: 2545
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.04
    Marker Score: 13740
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.03
    Marker Score: 1102
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.03
    Marker Score: 388
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.03
    Marker Score: 3058
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.03
    Marker Score: 420
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.03
    Marker Score: 577
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.03
    Marker Score: 1876
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.02
    Marker Score: 962
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.02
    Marker Score: 882
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.02
    Marker Score: 1080
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.01
    Marker Score: 320
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.01
    Marker Score: 242
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1
    Marker Score: 1422
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1
    Marker Score: 585
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1
    Marker Score: 1770
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1
    Marker Score: 4301
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1
    Marker Score: 1230
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71588
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.99
    Marker Score: 1071
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47810
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.99
    Marker Score: 286

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Other Information

**Key characteristics:** * DAP is a protein of the cysteine proteasome family. * It is expressed in a variety of cell types, including anterior lens cell, acinar cell of salivary gland, bladder urothelial cell, pneumocyte, pancreatic acinar cell, kidney collecting duct intercalated cell, type A enteroendocrine cell, peptic cell, and kidney loop of Henle thick ascending limb epithelial cell. * DAP is a key regulator of apoptosis. * It is involved in the regulation of autophagy, a process by which cells break down and recycle their own components. * It is also involved in the regulation of translation, a process by which the genetic information encoded by DNA is used to build proteins. **Pathways and functions:** * DAP is involved in the activation of cysteine-type endopeptidase activity, which is essential for the initiation of apoptosis. * It is also involved in the regulation of autophagy. * It is involved in the regulation of translation. **Clinical significance:** * Mutations in the DAP gene have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * Targeting DAP has been explored as a therapeutic strategy for cancer and other diseases that are characterized by excessive cell death.

Genular Protein ID: 1419481593

Symbol: DAP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P51397 Q6FGC3 Q9BUC9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828849

Title: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.

PubMed ID: 7828849

DOI: 10.1101/gad.9.1.15

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16602700

Title: Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins.

PubMed ID: 16602700

DOI: 10.1021/pr050415p

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20537536

Title: DAP1, a novel substrate of mTOR, negatively regulates autophagy.

PubMed ID: 20537536

DOI: 10.1016/j.cub.2010.04.041

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 102
  • Mass: 11165
  • Checksum: 52FBEFD23ABD182F
  • Sequence:
    • MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS 
GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK

Genular Protein ID: 3754185718

Symbol: B4DQ75_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DQ75

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 204
  • Mass: 23224
  • Checksum: 05A17C36622FF8A9
  • Sequence:
    • MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP RVTKISPRRL 
RRWLTRSRMP PWTSILPQEP STSSSHASEP GVHQPAPWPR LCCTWYFPDR ENQQFRPNPT 
LLGNLRQNQV LCPLPYISIF KTRNSSSPNL VYGESGWMSF EDHCAPRGAI SRICQDPRKI 
LALVLFQQSP DVLVYGLKNK KAHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.