Details for: DAP
Gene ID: 1611
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: DAP
Ensembl ID: ENSG00000112977
Description: death associated protein
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 30.1rCSI 40.01%PRS 35.57
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CSI 23.98rCSI 25.13%PRS 34.11
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CSI 16.72rCSI 36.63%PRS 41.33
-
CSI 13.42rCSI 14.38%PRS 30.07
-
CSI 13.41rCSI 10.9%PRS 33.12
-
CSI 13.26rCSI 25.78%PRS 33.4
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CSI 10.35rCSI 12.5%PRS 38.36
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CSI 10.34rCSI 21.24%PRS 29.82
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CSI 10.15rCSI 41.37%PRS 43.64
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CSI 9.97rCSI 15.3%PRS 37.88
-
CSI 9.26rCSI 13.55%PRS 34.3
-
CSI 8.52rCSI 22.96%PRS 40.61
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CSI 8rCSI 29.96%PRS 27.36
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CSI 7.67rCSI 14.37%PRS 24.34
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CSI 7.06rCSI 20.24%PRS 47.08
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CSI 6.93rCSI 27.57%PRS 48.45
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CSI 6.66rCSI 9.07%PRS 44.53
-
CSI 6.54rCSI 18.33%PRS 46.65
-
CSI 6.42rCSI 8%PRS 42.73
-
CSI 5.75rCSI 35.91%PRS 26.44
-
CSI 5.71rCSI 5.61%PRS 34.36
-
CSI 5.27rCSI 7.6%PRS 45.95
-
CSI 5.25rCSI 11.72%PRS 37.43
-
CSI 5.2rCSI 11.67%PRS 20.85
-
CSI 5rCSI 7.76%PRS 43.13
-
CSI 4.99rCSI 4.81%PRS 33.05
-
CSI 4.94rCSI 19.93%PRS 30.93
-
CSI 4.57rCSI 6.34%PRS 32.43
-
CSI 4.38rCSI 4.57%PRS 32.76
-
CSI 4.17rCSI 18.54%PRS 31.08
-
CSI 4.11rCSI 5.96%PRS 46.74
-
CSI 4.06rCSI 6%PRS 36.31
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CSI 3.71rCSI 5.92%PRS 27.55
-
CSI 3.51rCSI 4.82%PRS 53.22
-
CSI 3.37rCSI 2.35%PRS 38.81
-
CSI 3.37rCSI 8.01%PRS 44.36
-
CSI 3.33rCSI 3.01%PRS 29.53
-
CSI 3.23rCSI 4.59%PRS 30.01
-
CSI 3.2rCSI 2.43%PRS 41.73
-
CSI 3.14rCSI 30.88%PRS 62.4
-
CSI 3.14rCSI 3.88%PRS 28.75
-
CSI 3.04rCSI 13.18%PRS 48.69
-
CSI 3.02rCSI 4.04%PRS 39.57
-
CSI 2.95rCSI 4.08%PRS 39.36
-
CSI 2.94rCSI 4.76%PRS 31.61
-
CSI 2.93rCSI 6.48%PRS 29.86
-
CSI 2.88rCSI 14.21%PRS 42.18
-
CSI 2.84rCSI 2.2%PRS 31.75
-
CSI 2.72rCSI 63.41%PRS 54.63
-
CSI 2.67rCSI 7.04%PRS 37.95
-
CSI 2.61rCSI 1.54%PRS 44.48
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CSI 2.45rCSI 2.12%PRS 35.51
-
CSI 2.33rCSI 2.07%PRS 31.89
-
CSI 2.33rCSI 1.57%PRS 40.2
-
CSI 2.32rCSI 1.62%PRS 43.57
-
CSI 2.32rCSI 5.87%PRS 39.16
-
CSI 2.3rCSI 3.54%PRS 38.12
-
CSI 2.29rCSI 4.37%PRS 56.49
-
CSI 2.27rCSI 3.32%PRS 34.07
-
CSI 2.24rCSI 2.38%PRS 48.17
-
CSI 2.23rCSI 1.84%PRS 30.71
-
CSI 2.21rCSI 5.77%PRS 31.22
-
CSI 2.18rCSI 5.24%PRS 49.62
-
CSI 2.18rCSI 2.26%PRS 37.34
-
CSI 2.16rCSI 2.6%PRS 31.03
-
CSI 2.16rCSI 3.74%PRS 25.02
-
CSI 2.13rCSI 2.06%PRS 24.68
-
CSI 2.12rCSI 4.41%PRS 31.38
-
CSI 2.12rCSI 1.79%PRS 47.92
-
CSI 2.11rCSI 4.96%PRS 42.31
-
CSI 2.09rCSI 5.49%PRS 55.11
-
CSI 2.09rCSI 2.13%PRS 44.06
-
CSI 2.08rCSI 2.45%PRS 35.82
-
CSI 2.08rCSI 6.16%PRS 42.45
-
CSI 2.04rCSI 2%PRS 46.37
-
CSI 2.04rCSI 1.53%PRS 34.6
-
CSI 2.03rCSI 1.95%PRS 56.51
-
CSI 2.02rCSI 3.12%PRS 30.49
-
CSI 2.01rCSI 2.45%PRS 38.94
-
CSI 2rCSI 2.55%PRS 36.8
-
CSI 1.99rCSI 6.47%PRS 36.43
-
CSI 1.99rCSI 5.32%PRS 27.22
-
CSI 1.96rCSI 1.54%PRS 37.97
-
CSI 1.96rCSI 1.72%PRS 23.85
-
CSI 1.91rCSI 1.65%PRS 42.66
-
CSI 1.89rCSI 1.78%PRS 33.35
-
CSI 1.85rCSI 2.53%PRS 34.92
-
CSI 1.85rCSI 1.55%PRS 37.02
-
CSI 1.8rCSI 2.46%PRS 36.01
-
CSI 1.79rCSI 1.67%PRS 32.16
-
CSI 1.79rCSI 2.29%PRS 36.73
-
CSI 1.75rCSI 1.54%PRS 36.6
-
CSI 1.74rCSI 2.66%PRS 32.59
-
CSI 1.72rCSI 1.58%PRS 38.14
-
CSI 1.71rCSI 1.42%PRS 32.79
-
CSI 1.71rCSI 2.87%PRS 20.31
-
CSI 1.69rCSI 3.08%PRS 27.91
-
CSI 1.69rCSI 1.48%PRS 41.15
-
CSI 1.68rCSI 3.77%PRS 53.94
-
CSI 1.68rCSI 2.86%PRS 57.98
-
CSI 0.2rCSI 1.0%PRS 44.3%
-
CSI 0.2rCSI 1.1%PRS 43.4%
-
CSI 0.3rCSI 0.5%PRS 25.1%
-
CSI 0.3rCSI 2.0%PRS 52.9%
-
CSI 0.4rCSI 1.0%PRS 48.2%
-
CSI 0.4rCSI 2.1%PRS 43.9%
-
CSI 0.4rCSI 2.9%PRS 52.5%
-
CSI 0.4rCSI 2.7%PRS 65.0%
-
CSI 0.5rCSI 2.5%PRS 58.2%
-
CSI 0.5rCSI 1.5%PRS 21.3%
-
CSI 0.5rCSI 1.1%PRS 31.9%
-
CSI 0.5rCSI 3.0%PRS 68.4%
-
CSI 0.6rCSI 1.7%PRS 47.8%
-
CSI 0.6rCSI 1.8%PRS 35.1%
-
CSI 0.6rCSI 6.9%PRS 70.9%
-
CSI 0.7rCSI 3.0%PRS 61.2%
-
CSI 0.7rCSI 3.4%PRS 48.2%
-
CSI 0.7rCSI 3.0%PRS 50.0%
-
CSI 0.8rCSI 2.1%PRS 50.1%
-
CSI 0.8rCSI 4.2%PRS 48.7%
-
CSI 0.8rCSI 2.8%PRS 46.5%
-
CSI 0.8rCSI 3.6%PRS 28.2%
-
CSI 0.8rCSI 1.2%PRS 47.7%
-
CSI 0.8rCSI 3.9%PRS 35.8%
-
CSI 0.9rCSI 1.3%PRS 36.4%
-
CSI 0.9rCSI 3.5%PRS 55.4%
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CSI 0.9rCSI 2.5%PRS 51.1%
-
CSI 0.9rCSI 1.4%PRS 27.3%
-
CSI 0.9rCSI 0.7%PRS 32.4%
-
CSI 0.9rCSI 2.7%PRS 57.6%
-
CSI 0.9rCSI 1.4%PRS 40.4%
-
CSI 1.0rCSI 1.5%PRS 33.3%
-
CSI 1.0rCSI 2.3%PRS 35.2%
-
CSI 1.0rCSI 1.5%PRS 48.3%
-
CSI 1.0rCSI 3.4%PRS 43.8%
-
CSI 1.0rCSI 1.2%PRS 50.6%
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CSI 1.0rCSI 3.7%PRS 49.0%
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CSI 1.1rCSI 4.4%PRS 44.6%
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CSI 1.1rCSI 2.6%PRS 30.5%
-
CSI 1.1rCSI 1.1%PRS 27.6%
-
CSI 1.1rCSI 2.4%PRS 45.9%
-
CSI 1.1rCSI 2.1%PRS 61.0%
-
CSI 1.1rCSI 1.9%PRS 19.7%
-
CSI 1.1rCSI 1.6%PRS 41.5%
-
CSI 1.1rCSI 2.1%PRS 40.6%
-
CSI 1.1rCSI 2.1%PRS 47.1%
-
CSI 1.2rCSI 3.0%PRS 29.6%
-
CSI 1.2rCSI 3.0%PRS 38.3%
-
CSI 1.2rCSI 1.7%PRS 25.6%
-
CSI 1.2rCSI 1.9%PRS 35.1%
-
CSI 1.2rCSI 3.8%PRS 29.1%
-
CSI 1.2rCSI 1.0%PRS 39.9%
-
CSI 1.2rCSI 2.9%PRS 37.9%
-
CSI 1.2rCSI 2.2%PRS 30.5%
-
CSI 1.2rCSI 0.9%PRS 30.7%
-
CSI 1.2rCSI 0.9%PRS 33.8%
-
CSI 1.2rCSI 19.1%PRS 61.2%
-
CSI 1.3rCSI 1.7%PRS 44.0%
-
CSI 1.3rCSI 1.4%PRS 32.7%
-
CSI 1.3rCSI 1.7%PRS 19.1%
-
CSI 1.3rCSI 6.8%PRS 74.0%
-
CSI 1.3rCSI 3.4%PRS 25.1%
-
CSI 1.4rCSI 5.3%PRS 41.7%
-
CSI 1.4rCSI 3.5%PRS 30.5%
-
CSI 1.4rCSI 1.0%PRS 44.4%
-
CSI 1.4rCSI 1.9%PRS 21.0%
-
CSI 1.4rCSI 3.5%PRS 30.2%
-
CSI 1.5rCSI 1.7%PRS 42.9%
-
CSI 1.5rCSI 1.0%PRS 36.5%
-
CSI 1.5rCSI 1.7%PRS 24.4%
-
CSI 1.5rCSI 1.2%PRS 22.7%
-
CSI 1.5rCSI 2.4%PRS 25.3%
-
CSI 1.5rCSI 3.1%PRS 46.9%
-
CSI 1.5rCSI 6.5%PRS 52.1%
-
CSI 1.5rCSI 2.1%PRS 41.9%
-
CSI 1.5rCSI 1.9%PRS 40.6%
-
CSI 1.5rCSI 2.2%PRS 40.1%
-
CSI 1.5rCSI 1.8%PRS 28.2%
-
CSI 1.5rCSI 1.9%PRS 34.5%
-
CSI 1.6rCSI 3.1%PRS 32.6%
-
CSI 1.6rCSI 2.6%PRS 43.1%
-
CSI 1.6rCSI 2.3%PRS 34.9%
-
CSI 1.6rCSI 2.5%PRS 32.8%
-
CSI 1.6rCSI 2.8%PRS 25.9%
-
CSI 1.6rCSI 3.5%PRS 53.2%
-
CSI 1.6rCSI 3.7%PRS 31.7%
-
CSI 1.6rCSI 1.7%PRS 30.1%
-
CSI 1.6rCSI 1.8%PRS 35.6%
-
CSI 1.7rCSI 1.5%PRS 52.1%
-
CSI 1.7rCSI 3.6%PRS 35.9%
-
CSI 1.7rCSI 2.6%PRS 41.0%
-
CSI 1.7rCSI 2.9%PRS 58.0%
-
CSI 1.7rCSI 3.8%PRS 53.9%
-
CSI 1.7rCSI 1.5%PRS 41.2%
-
CSI 1.7rCSI 3.1%PRS 27.9%
-
CSI 1.7rCSI 2.9%PRS 20.3%
-
CSI 1.7rCSI 1.4%PRS 32.8%
-
CSI 1.7rCSI 1.6%PRS 38.1%
-
CSI 1.7rCSI 2.7%PRS 32.6%
-
CSI 1.8rCSI 1.5%PRS 36.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1419481593
Symbol: DAP1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7828849
Title: Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.
PubMed ID: 7828849
DOI: 10.1101/gad.9.1.15
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16602700
Title: Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins.
PubMed ID: 16602700
DOI: 10.1021/pr050415p
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20537536
Title: DAP1, a novel substrate of mTOR, negatively regulates autophagy.
PubMed ID: 20537536
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 102
- Mass: 11165
- Checksum: 52FBEFD23ABD182F
- Sequence:
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP SPPKPTVFIS GVIARGDKDF PPAAAQVAHQ KPHASMDKHP SPRTQHIQQP RK
Genular Protein ID: 3754185718
Symbol: B4DQ75_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15372022
Title: The DNA sequence and comparative analysis of human chromosome 5.
PubMed ID: 15372022
DOI: 10.1038/nature02919
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
Sequence Information:
- Length: 204
- Mass: 23224
- Checksum: 05A17C36622FF8A9
- Sequence:
MSSPPEGKLE TKAGHPPAVK AGGMRIVQKH PHTGDTKEEK DKDDQEWESP RVTKISPRRL RRWLTRSRMP PWTSILPQEP STSSSHASEP GVHQPAPWPR LCCTWYFPDR ENQQFRPNPT LLGNLRQNQV LCPLPYISIF KTRNSSSPNL VYGESGWMSF EDHCAPRGAI SRICQDPRKI LALVLFQQSP DVLVYGLKNK KAHI