Genular: Defining Cellular Identity and Function

Details for: Igtp

Gene ID: 16145

Symbol: Igtp

Ensembl ID: ENSMUSG00000078853

Description: interferon gamma induced GTPase

Associated with

Autophagosome assembly
(GO:0000045)
Autophagosome membrane
(GO:0000421)
Autophagy
(GO:0006914)
Bh3 domain binding
(GO:0051434)
Camkk-ampk signaling cascade
(GO:0061762)
Card domain binding
(GO:0050700)
Cardiolipin binding
(GO:1901612)
Cd8-positive, alpha-beta t cell differentiation
(GO:0043374)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to virus
(GO:0098586)
Cytolysis in another organism
(GO:0051715)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response
(GO:0006952)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to protozoan
(GO:0042832)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Lipid droplet
(GO:0005811)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of defense response to virus
(GO:0050687)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of nlrp3 inflammasome complex assembly
(GO:1900226)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Negative regulation of type i interferon production
(GO:0032480)
Nucleotide-binding oligomerization domain containing 2 signaling pathway
(GO:0070431)
Nucleotide binding
(GO:0000166)
Positive regulation of autophagosome maturation
(GO:1901098)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of lysosome organization
(GO:1905673)
Positive regulation of mitochondrial fission
(GO:0090141)
Positive regulation of mitophagy
(GO:1901526)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of type ii interferon-mediated signaling pathway
(GO:0060335)
Positive regulation of xenophagy
(GO:1904417)
Protein-containing complex assembly
(GO:0065003)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein destabilization
(GO:0031648)
Protein kinase binding
(GO:0019901)
Protein lipidation involved in autophagosome assembly
(GO:0061739)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein stabilization
(GO:0050821)
Protein targeting to vacuole involved in autophagy
(GO:0071211)
Regulation of protein-containing complex assembly
(GO:0043254)
Regulation of protein complex stability
(GO:0061635)

Other Information

Proteins

IRGM3_MOUSE

Genular Protein ID: 2295265856

Symbol: IRGM3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9DCE9 J7PDL1 Q8C2M8

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22892676

Title: Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases.

PubMed ID: 22892676

DOI: 10.1007/s10142-012-0291-2

PubMed ID: 8702776

Title: Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma.

PubMed ID: 8702776

DOI: 10.1074/jbc.271.34.20399

PubMed ID: 9099712

Title: The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding.

PubMed ID: 9099712

DOI: 10.1074/jbc.272.16.10639

PubMed ID: 10639151

Title: Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.

PubMed ID: 10639151

DOI: 10.1073/pnas.97.2.751

PubMed ID: 11500431

Title: Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP.

PubMed ID: 11500431

DOI: 10.1128/iai.69.9.5573-5576.2001

PubMed ID: 12438372

Title: The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments.

PubMed ID: 12438372

DOI: 10.1128/iai.70.12.6933-6939.2002

PubMed ID: 16940170

Title: Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages.

PubMed ID: 16940170

DOI: 10.1084/jem.20061318

PubMed ID: 18765738

Title: The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes.

PubMed ID: 18765738

DOI: 10.1128/iai.01288-07

PubMed ID: 21981022

Title: The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.

PubMed ID: 21981022

DOI: 10.1111/j.1462-5822.2011.01708.x

PubMed ID: 25644000

Title: IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.

PubMed ID: 25644000

DOI: 10.1128/iai.02701-14

PubMed ID: 23785284

Title: IRG and GBP host resistance factors target aberrant, 'non-self' vacuoles characterized by the missing of 'self' IRGM proteins.

PubMed ID: 23785284

DOI: 10.1371/journal.ppat.1003414

PubMed ID: 36629440

Title: Differential requirement for IRGM proteins during Tuberculosis infection in mice.

PubMed ID: 36629440

DOI: 10.1128/iai.00510-22

Sequence Information:

Length: 423
Mass: 48494
Checksum: 8FAA2254A6DF4574
Sequence:

MDLVTKLPQN IWKTFTLFIN MANYLKRLIS PWSKSMTAGE SLYSSQNSSS PEVIEDIGKA 
VTEGNLQKVI GIVKDEIQSK SRYRVKIAVT GDSGNGMSSF INALRFIGHE EEDSAPTGVV 
RTTKKPACYS SDSHFPYVEL WDLPGLGATA QSVESYLEEM QISTFDLIII VASEQFSSNH 
VKLAITMQRM RKRFYVVWTK LDRDLSTSTF PEPQLLQSIQ RNIRENLQQA QVRDPPLFLI 
SCFSPSFHDF PELRNTLQKD IFSIRYRDPL EIISQVCDKC ISNKAFSLKE DQMLMKDLEA 
AVSSEDDTAN LERGLQTYQK LFGVDDGSLQ QVARSTGRLE MGSRALQFQD LIKMDRRLEL 
MMCFAVNKFL RLLESSWWYG LWNVVTRYFR HQRHKLVIEI VAENTKTSLR KALKDSVLPP 
EIH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Igtp

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative genomic analysis of eutherian interferon-gamma-inducible GTPases. PubMed ID: 22892676

Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. PubMed ID: 8702776

The inducibly expressed GTPase localizes to the endoplasmic reticulum, independently of GTP binding. PubMed ID: 9099712

Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. PubMed ID: 10639151

Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP. PubMed ID: 11500431

The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments. PubMed ID: 12438372

Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. PubMed ID: 16940170

The gamma interferon (IFN-gamma)-inducible GTP-binding protein IGTP is necessary for toxoplasma vacuolar disruption and induces parasite egression in IFN-gamma-stimulated astrocytes. PubMed ID: 18765738

The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway. PubMed ID: 21981022

IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria. PubMed ID: 25644000

IRG and GBP host resistance factors target aberrant, 'non-self' vacuoles characterized by the missing of 'self' IRGM proteins. PubMed ID: 23785284

Differential requirement for IRGM proteins during Tuberculosis infection in mice. PubMed ID: 36629440