Genular: Defining Cellular Identity and Function

Details for: Ihh

Gene ID: 16147

Symbol: Ihh

Ensembl ID: ENSMUSG00000006538

Description: Indian hedgehog

Associated with

Activation of smo
(R-MMU-5635838)
Hedgehog 'on' state
(R-MMU-5632684)
Hedgehog ligand biogenesis
(R-MMU-5358346)
Ligand-receptor interactions
(R-MMU-5632681)
Release of hh-np from the secreting cell
(R-MMU-5362798)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
Bone resorption
(GO:0045453)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Calcium ion binding
(GO:0005509)
Camera-type eye development
(GO:0043010)
Camera-type eye photoreceptor cell fate commitment
(GO:0060220)
Cartilage development
(GO:0051216)
Cell-cell signaling
(GO:0007267)
Cell fate specification
(GO:0001708)
Cell maturation
(GO:0048469)
Cell population proliferation
(GO:0008283)
Chondrocyte differentiation
(GO:0002062)
Chondrocyte differentiation involved in endochondral bone morphogenesis
(GO:0003413)
Chondrocyte proliferation
(GO:0035988)
Embryo development
(GO:0009790)
Embryonic camera-type eye morphogenesis
(GO:0048596)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic pattern specification
(GO:0009880)
Embryonic skeletal joint development
(GO:0072498)
Endochondral bone morphogenesis
(GO:0060350)
Endoplasmic reticulum
(GO:0005783)
Epithelial cell-cell adhesion
(GO:0090136)
Epithelial cell morphogenesis
(GO:0003382)
Extracellular matrix
(GO:0031012)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Head morphogenesis
(GO:0060323)
Heart looping
(GO:0001947)
Hydrolase activity
(GO:0016787)
Intein-mediated protein splicing
(GO:0016539)
In utero embryonic development
(GO:0001701)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Morphogenesis of a branching structure
(GO:0001763)
Multicellular organism development
(GO:0007275)
Multicellular organism growth
(GO:0035264)
Negative regulation of alpha-beta t cell differentiation
(GO:0046639)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of chondrocyte differentiation
(GO:0032331)
Negative regulation of eye pigmentation
(GO:0048074)
Negative regulation of immature t cell proliferation in thymus
(GO:0033088)
Negative regulation of t cell differentiation in thymus
(GO:0033085)
Neuron development
(GO:0048666)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Pancreas development
(GO:0031016)
Patched binding
(GO:0005113)
Pattern specification process
(GO:0007389)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Positive regulation of alpha-beta t cell differentiation
(GO:0046638)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of mesenchymal cell proliferation
(GO:0002053)
Positive regulation of smoothened signaling pathway
(GO:0045880)
Positive regulation of t cell differentiation in thymus
(GO:0033089)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein autoprocessing
(GO:0016540)
Protein binding
(GO:0005515)
Proteoglycan metabolic process
(GO:0006029)
Proteolysis
(GO:0006508)
Regulation of gene expression
(GO:0010468)
Regulation of growth
(GO:0040008)
Retinal pigment epithelium development
(GO:0003406)
Skeletal system development
(GO:0001501)
Smoothened signaling pathway
(GO:0007224)
Smooth muscle tissue development
(GO:0048745)
Somite development
(GO:0061053)
Transferase activity
(GO:0016740)
Vasculature development
(GO:0001944)
Very-low-density lipoprotein particle binding
(GO:0034189)
Vitelline membrane formation
(GO:0030704)

Other Information

Proteins

HHG-2
Q80XI9_MOUSE

Genular Protein ID: 3411418268

Symbol: IHH_MOUSE

Name: HHG-2

UniProtKB Accession Codes:

P97812 Q61724

Database IDs:

Citations:

PubMed ID: 9079674

Title: Post-translational processing and renal expression of mouse indian hedgehog.

PubMed ID: 9079674

DOI: 10.1074/jbc.272.13.8466

PubMed ID: 7916661

Title: Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity.

PubMed ID: 7916661

DOI: 10.1016/0092-8674(93)90627-3

PubMed ID: 7720571

Title: Products, genetic linkage and limb patterning activity of a murine hedgehog gene.

PubMed ID: 7720571

DOI: 10.1242/dev.120.11.3339

PubMed ID: 10465785

Title: Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

PubMed ID: 10465785

DOI: 10.1101/gad.13.16.2072

PubMed ID: 10631175

Title: Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways.

PubMed ID: 10631175

DOI: 10.1242/dev.127.3.543

PubMed ID: 23665349

Title: Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex.

PubMed ID: 23665349

DOI: 10.1016/j.ajpath.2013.03.013

Sequence Information:

Length: 411
Mass: 45485
Checksum: 08BE7AD8507C0D9B
Sequence:

MSPAWLRPRL RFCLFLLLLL LVPAARGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 
LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 
QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 
ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLENGERVAL SAVKPGDRVL AMGEDGTPTF 
SDVLIFLDRE PNRLRAFQVI ETQDPPRRLA LTPAHLLFIA DNHTEPAAHF RATFASHVQP 
GQYVLVSGVP GLQPARVAAV STHVALGSYA PLTRHGTLVV EDVVASCFAA VADHHLAQLA 
FWPLRLFPSL AWGSWTPSEG VHWYPQMLYR LGRLLLEEST FHPLGMSGAG S

Genular Protein ID: 4112374697

Symbol: Q80XI9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80XI9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 449
Mass: 49445
Checksum: F9ACF5B4E935E9AE
Sequence:

MESPRATQTP ESPKLSQPRA HLSAHQAPSP AALPGYPAMS PAWLRPRLRF CLFLLLLLLV 
PAARGCGPGR VVGSRRRPPR KLVPLAYKQF SPNVPEKTLG ASGRYEGKIA RSSERFKELT 
PNYNPDIIFK DEENTGADRL MTQRCKDRLN SLAISVMNQW PGVKLRVTEG WDEDGHHSEE 
SLHYEGRAVD ITTSDRDRNK YGLLARLAVE AGFDWVYYES KAHVHCSVKS EHSAAAKTGG 
CFPAGAQVRL ENGERVALSA VKPGDRVLAM GEDGTPTFSD VLIFLDREPN RLRAFQVIET 
QDPPRRLALT PAHLLFIADN HTEPAAHFRA TFASHVQPGQ YVLVSGVPGL QPARVAAVST 
HVALGSYAPL TRHGTLVVED VVASCFAAVA DHHLAQLAFW PLRLFPSLAW GSWTPSEGVH 
WYPQMLYRLG RLLLEESTFH PLGMSGAGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ihh

Associated with

Other Information

Post-translational processing and renal expression of mouse indian hedgehog. PubMed ID: 9079674

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. PubMed ID: 7916661

Products, genetic linkage and limb patterning activity of a murine hedgehog gene. PubMed ID: 7720571

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. PubMed ID: 10465785

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways. PubMed ID: 10631175

Regulation of liver growth by glypican 3, CD81, hedgehog, and Hhex. PubMed ID: 23665349

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073