Details for: Cd74

Gene ID: 16149

Symbol: Cd74

Ensembl ID: ENSMUSG00000024610

Description: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)

Associated with

  • Adaptive immune system
    (R-MMU-1280218)
  • Cell surface interactions at the vascular wall
    (R-MMU-202733)
  • Hemostasis
    (R-MMU-109582)
  • Immune system
    (R-MMU-168256)
  • Mhc class ii antigen presentation
    (R-MMU-2132295)
  • Adaptive immune response
    (GO:0002250)
  • Amyloid-beta binding
    (GO:0001540)
  • Antigen processing and presentation
    (GO:0019882)
  • Antigen processing and presentation of exogenous peptide antigen via mhc class ii
    (GO:0019886)
  • Cd4 receptor binding
    (GO:0042609)
  • Cell surface
    (GO:0009986)
  • Chaperone cofactor-dependent protein refolding
    (GO:0051085)
  • Cytokine binding
    (GO:0019955)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytoplasm
    (GO:0005737)
  • Defense response
    (GO:0006952)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endosome
    (GO:0005768)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Golgi apparatus
    (GO:0005794)
  • Immune response
    (GO:0006955)
  • Immune system process
    (GO:0002376)
  • Immunoglobulin mediated immune response
    (GO:0016064)
  • Intracellular protein transport
    (GO:0006886)
  • Late endosome
    (GO:0005770)
  • Lysosome
    (GO:0005764)
  • Macrophage migration inhibitory factor binding
    (GO:0035718)
  • Macrophage migration inhibitory factor signaling pathway
    (GO:0035691)
  • Mhc class ii protein binding
    (GO:0042289)
  • Mhc class ii protein binding, via antigen binding groove
    (GO:0042658)
  • Mhc class ii protein complex binding
    (GO:0023026)
  • Multivesicular body
    (GO:0005771)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:1902166)
  • Negative regulation of mature b cell apoptotic process
    (GO:0002906)
  • Negative regulation of peptide secretion
    (GO:0002792)
  • Negative regulation of t cell differentiation
    (GO:0045581)
  • Negative regulation of viral entry into host cell
    (GO:0046597)
  • Negative thymic t cell selection
    (GO:0045060)
  • Nitric-oxide synthase binding
    (GO:0050998)
  • Nucleus
    (GO:0005634)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of adaptive immune response
    (GO:0002821)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000343)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine-mediated signaling pathway
    (GO:0001961)
  • Positive regulation of dendritic cell antigen processing and presentation
    (GO:0002606)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of innate immune response
    (GO:0045089)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of macrophage migration inhibitory factor signaling pathway
    (GO:2000448)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of monocyte differentiation
    (GO:0045657)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of prostaglandin biosynthetic process
    (GO:0031394)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of type 2 immune response
    (GO:0002830)
  • Positive regulation of viral entry into host cell
    (GO:0046598)
  • Positive thymic t cell selection
    (GO:0045059)
  • Prostaglandin biosynthetic process
    (GO:0001516)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein folding chaperone
    (GO:0044183)
  • Protein stabilization
    (GO:0050821)
  • Protein trimerization
    (GO:0070206)
  • Response to type ii interferon
    (GO:0034341)
  • T cell activation involved in immune response
    (GO:0002286)
  • Vacuole
    (GO:0005773)

Other Information

Genular Protein ID: 744781183

Symbol: HG2A_MOUSE

Name: Ia antigen-associated invariant chain

UniProtKB Accession Codes:

P04441 O19452

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 77 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MEROPS 1 MGI 2 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3038530

Title: Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

PubMed ID: 3038530

DOI: 10.1002/j.1460-2075.1987.tb02417.x

PubMed ID: 2492095

Title: Complete sequence of the murine invariant chain (Ii) gene.

PubMed ID: 2492095

DOI: 10.1093/nar/17.1.447

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2111346

Title: The IFN-gamma response of the murine invariant chain gene is mediated by a complex enhancer that includes several MHC class II consensus elements.

PubMed ID: 2111346

PubMed ID: 6327293

Title: Structure of the murine Ia-associated invariant (Ii) chain as deduced from a cDNA clone.

PubMed ID: 6327293

DOI: 10.1002/j.1460-2075.1984.tb01899.x

PubMed ID: 3422739

Title: Identification of the glycosaminoglycan-attachment site of mouse invariant-chain proteoglycan core protein by site-directed mutagenesis.

PubMed ID: 3422739

DOI: 10.1073/pnas.85.5.1359

PubMed ID: 8343954

Title: The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.

PubMed ID: 8343954

DOI: 10.1016/0092-8674(93)90417-o

PubMed ID: 8977190

Title: In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

PubMed ID: 8977190

PubMed ID: 11483509

Title: The p41 isoform of invariant chain is a chaperone for cathepsin L.

PubMed ID: 11483509

DOI: 10.1093/emboj/20.15.4055

PubMed ID: 12417635

Title: Invariant chain controls the activity of extracellular cathepsin L.

PubMed ID: 12417635

DOI: 10.1084/jem.20020762

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

Sequence Information:

  • Length: 279
  • Mass: 31557
  • Checksum: 300A85014F170792
  • Sequence:
    • MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT AYFLYQQQGR 
LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM 
TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL 
EEKKPTEAPP KVLTKCQEEV SHIPAVYPGA FRPKCDENGN YLPLQCHGST GYCWCVFPNG 
TEVPHTKSRG RHNCSEPLDM EDLSSGLGVT RQELGQVTL

Genular Protein ID: 3748413059

Symbol: Q545Y5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q545Y5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 7 Gene3D 1 HOGENOM 1 InterPro 5 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 Pfam 4 RefSeq 2 SAM 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 215
  • Mass: 24454
  • Checksum: 090928B6B0F4200C
  • Sequence:
    • MDDQRDLISN HEQLPILGNR PREPERCSRG ALYTGVSVLV ALLLAGQATT AYFLYQQQGR 
LDKLTITSQN LQLESLRMKL PKSAKPVSQM RMATPLLMRP MSMDNMLLGP VKNVTKYGNM 
TQDHVMHLLT RSGPLEYPQL KGTFPENLKH LKNSMDGVNW KIFESWMKQW LLFEMSKNSL 
EEKKPTEAPP KEPLDMEDLS SGLGVTRQEL GQVTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.