Genular: Defining Cellular Identity and Function

Details for: Ikbkb

Gene ID: 16150

Symbol: Ikbkb

Ensembl ID: ENSMUSG00000031537

Description: inhibitor of kappaB kinase beta

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Irak1 recruits ikk complex
(R-MMU-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-MMU-975144)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-MMU-5684264)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nf-kb is activated and signals survival
(R-MMU-209560)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pkr-mediated signaling
(R-MMU-9833482)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Atp binding
(GO:0005524)
B cell homeostasis
(GO:0001782)
Canonical nf-kappab signal transduction
(GO:0007249)
Cortical actin cytoskeleton organization
(GO:0030866)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Ikappab kinase activity
(GO:0008384)
Kinase activity
(GO:0016301)
Negative regulation of myosin-light-chain-phosphatase activity
(GO:0035509)
Neuron projection development
(GO:0031175)
Nucleotide binding
(GO:0000166)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of sodium ion transport
(GO:0010765)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of phosphorylation
(GO:0042325)
Scaffold protein binding
(GO:0097110)
Transferase activity
(GO:0016740)
Transferrin receptor binding
(GO:1990459)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

Genular Protein ID: 2597291103

Symbol: IKKB_MOUSE

Name: Inhibitor of nuclear factor kappa-B kinase subunit beta

UniProtKB Accession Codes:

O88351 Q9R1J6

Database IDs:

Citations:

PubMed ID: 9520401

Title: Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.

PubMed ID: 9520401

DOI: 10.1073/pnas.95.7.3537

PubMed ID: 10229185

Title: Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice.

PubMed ID: 10229185

DOI: 10.1016/s1074-7613(00)80042-4

PubMed ID: 10523828

Title: Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase.

PubMed ID: 10523828

DOI: 10.1038/sj.onc.1202740

PubMed ID: 9819420

Title: Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.

PubMed ID: 9819420

DOI: 10.1128/mcb.18.12.7336

PubMed ID: 10195897

Title: Severe liver degeneration in mice lacking the IkappaB kinase 2 gene.

PubMed ID: 10195897

DOI: 10.1126/science.284.5412.321

PubMed ID: 10712233

Title: The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.

PubMed ID: 10712233

DOI: 10.1152/ajpcell.2000.278.3.c451

PubMed ID: 10848580

Title: PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex.

PubMed ID: 10848580

DOI: 10.1128/mcb.20.13.4532-4542.2000

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20622870

Title: Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.

PubMed ID: 20622870

DOI: 10.1038/ncb2080

PubMed ID: 22037600

Title: The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

PubMed ID: 22037600

DOI: 10.1038/ni.2137

PubMed ID: 23090968

Title: A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy.

PubMed ID: 23090968

DOI: 10.1128/mcb.00887-12

PubMed ID: 25326420

Title: IKKbeta is an IRF5 kinase that instigates inflammation.

PubMed ID: 25326420

DOI: 10.1073/pnas.1418516111

PubMed ID: 30988283

Title: Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.

PubMed ID: 30988283

DOI: 10.1038/s41467-019-09690-0

Sequence Information:

Length: 757
Mass: 86690
Checksum: FED962F095449C5E
Sequence:

MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRNRWCL 
EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG 
AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT 
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 
VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF 
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QENTGILETD QELLQKAGLV 
LLPDKPATQC ISDSKTNEGL TLDMDLVFLL DNSKINYETQ ITPRPPPESV SCILQEPKRN 
LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK 
AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL 
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRKLREKPRD QRTEGDSQEM VRLLLQAIQS 
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI 
ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE 
SALQDTVKEQ DRSFTTLDWS WLQMEDEERC SLEQACD

Genular Protein ID: 3510600941

Symbol: A0A0R4J0T4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0T4

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 738
Mass: 84388
Checksum: 73DD395ADE91C2C8
Sequence:

MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRDRWCL 
EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG 
AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT 
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 
VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF 
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QEDTGILETD QELLQEAGLV 
LLPDKPATQC ISDSKTNEGL TLDMDLVFLF DNSKINYETQ ITPRPQPESV SCILQEPKRN 
LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK 
AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL 
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS 
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI 
ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE 
SALQDTVKEQ DRSFTVTA

Genular Protein ID: 462360245

Symbol: Q5D0E0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5D0E0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 757
Mass: 86786
Checksum: 64CFF64F3958AE0D
Sequence:

MSWSPSLPTQ TCGAWEMKER LGTGGFGNVI RWHNQATGEQ IAIKQCRQEL SPKNRDRWCL 
EIQIMRRLNH PNVVAARDVP EGMQNLAPND LPLLAMEYCQ GGDLRRYLNQ FENCCGLREG 
AVLTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEKRL IHKIIDLGYA KELDQGSLCT 
SFVGTLQYLA PELLEQQKYT VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 
VDIVVSEDLN GAVKFSSSLP FPNNLNSVLA ERLEKWLQLM LMWHPRQRGT DPQYGPNGCF 
RALDDILNLK LVHVLNMVTG TVHTYPVTED ESLQSLKTRI QEDTGILETD QELLQEAGLV 
LLPDKPATQC ISDSKTNEGL TLDMDLVFLF DNSKINYETQ ITPRPQPESV SCILQEPKRN 
LSFFQLRKVW GQVWHSIQTL KEDCNRLQQG QRAAMMSLLR NNSCLSKMKN AMASTAQQLK 
AKLDFFKTSI QIDLEKYKEQ TEFGITSDKL LLAWREMEQA VEQCGRENDV KHLVERMMAL 
QTDIVDLQRS PMGRKQGGTL DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS 
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE RTVVRLQEKR QKELWNLLKI 
ACSKVRGPVS GSPDSMNVSR LSHPGQLMSQ PSSACDSLPE SDKKSEELVA EAHALCSRLE 
SALQDTVKEQ DRSFTTLDWS WLQMEDEERC SLEQACD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ikbkb

Associated with

Other Information

Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. PubMed ID: 9520401

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. PubMed ID: 10229185

Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase. PubMed ID: 10523828

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. PubMed ID: 9819420

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. PubMed ID: 10195897

The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection. PubMed ID: 10712233

PKR stimulates NF-kappaB irrespective of its kinase function by interacting with the IkappaB kinase complex. PubMed ID: 10848580

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. PubMed ID: 20622870

The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. PubMed ID: 22037600

A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to support interleukin-6-mediated cardiomyocyte hypertrophy. PubMed ID: 23090968

IKKbeta is an IRF5 kinase that instigates inflammation. PubMed ID: 25326420

Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. PubMed ID: 30988283

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9520401

PubMed ID: 10229185

PubMed ID: 10523828

PubMed ID: 9819420

PubMed ID: 10195897

PubMed ID: 10712233

PubMed ID: 10848580

PubMed ID: 21183079

PubMed ID: 20622870

PubMed ID: 22037600

PubMed ID: 23090968

PubMed ID: 25326420

PubMed ID: 30988283

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 15489334

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 21183079