Genular: Defining Cellular Identity and Function

Details for: Ikbkg

Gene ID: 16151

Symbol: Ikbkg

Ensembl ID: ENSMUSG00000004221

Description: inhibitor of kappaB kinase gamma

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Irak1 recruits ikk complex
(R-MMU-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-MMU-975144)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-MMU-450321)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-MMU-5684264)
Map kinase activation
(R-MMU-450294)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Ovarian tumor domain proteases
(R-MMU-5689896)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Rip-mediated nfkb activation via zbp1
(R-MMU-1810476)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of immune response proteins
(R-MMU-4755510)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6 mediated nf-kb activation
(R-MMU-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Anoikis
(GO:0043276)
B cell homeostasis
(GO:0001782)
Canonical nf-kappab signal transduction
(GO:0007249)
Defense response to bacterium
(GO:0042742)
Dna damage response
(GO:0006974)
Establishment of vesicle localization
(GO:0051650)
Identical protein binding
(GO:0042802)
K63-linked polyubiquitin modification-dependent protein binding
(GO:0070530)
Linear polyubiquitin binding
(GO:1990450)
Metal ion binding
(GO:0046872)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Polyubiquitin modification-dependent protein binding
(GO:0031593)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of macroautophagy
(GO:0016239)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of t cell receptor signaling pathway
(GO:0050862)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Signaling adaptor activity
(GO:0035591)
Transferrin receptor binding
(GO:1990459)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Genular Protein ID: 2050034132

Symbol: NEMO_MOUSE

Name: NF-kappa-B essential modulator

UniProtKB Accession Codes:

O88522 Q924H4

Database IDs:

Citations:

PubMed ID: 9657155

Title: Complementation cloning of NEMO, a component of the I-kappaB kinase complex essential for NF-kappaB activation.

PubMed ID: 9657155

DOI: 10.1016/s0092-8674(00)81466-x

PubMed ID: 11410370

Title: Human-mouse comparative sequence analysis of the NEMO gene reveals an alternative promoter within the neighboring G6PD gene.

PubMed ID: 11410370

DOI: 10.1016/s0378-1119(01)00492-9

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9891086

Title: IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex.

PubMed ID: 9891086

DOI: 10.1128/mcb.19.2.1526

PubMed ID: 9927690

Title: Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis.

PubMed ID: 9927690

DOI: 10.1073/pnas.96.3.1042

PubMed ID: 11080499

Title: Role of ikkgamma/nemo in assembly of the IkappaB kinase complex.

PubMed ID: 11080499

DOI: 10.1074/jbc.m008353200

PubMed ID: 11971901

Title: Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation.

PubMed ID: 11971901

DOI: 10.1074/jbc.m201393200

PubMed ID: 12133833

Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.

PubMed ID: 12133833

DOI: 10.1074/jbc.m205069200

PubMed ID: 16684768

Title: ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.

PubMed ID: 16684768

DOI: 10.1074/jbc.m601502200

PubMed ID: 17728323

Title: Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti.

PubMed ID: 17728323

DOI: 10.1093/hmg/ddm237

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20622870

Title: Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression.

PubMed ID: 20622870

DOI: 10.1038/ncb2080

PubMed ID: 31519886

Title: Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.

PubMed ID: 31519886

DOI: 10.1038/s41467-019-11839-w

PubMed ID: 32935379

Title: Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2.

PubMed ID: 32935379

DOI: 10.15252/embj.2020105139

PubMed ID: 19303852

Title: Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation.

PubMed ID: 19303852

DOI: 10.1016/j.cell.2009.03.007

PubMed ID: 19854204

Title: DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding.

PubMed ID: 19854204

DOI: 10.1016/j.jmb.2009.10.018

Sequence Information:

Length: 412
Mass: 47972
Checksum: 66C693C857A2D5E6
Sequence:

MNKHPWKNQL SEMVQPSGGP AEDQDMLGEE SSLGKPAMLH LPSEQGTPET LQRCLEENQE 
LRDAIRQSNQ MLRERCEELL HFQVSQREEK EFLMCKFQEA RKLVERLSLE KLDLRSQREQ 
ALKELEQLKK CQQQMAEDKA SVKAQVTSLL GELQESQSRL EAATKDRQAL EGRIRAVSEQ 
VRQLESEREV LQQQHSVQVD QLRMQNQSVE AALRMERQAA SEEKRKLAQL QAAYHQLFQD 
YDSHIKSSKG MQLEDLRQQL QQAEEALVAK QELIDKLKEE AEQHKIVMET VPVLKAQADI 
YKADFQAERH AREKLVEKKE YLQEQLEQLQ REFNKLKVGC HESARIEDMR KRHVETPQPP 
LLPAPAHHSF HLALSNQRRS PPEEPPDFCC PKCQYQAPDM DTLQIHVMEC IE

Genular Protein ID: 690450927

Symbol: Q7TSS3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q7TSS3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 430
Mass: 50199
Checksum: F3E29FCA8088B184
Sequence:

MYIRYCCDDQ DTQTLSCWMN KHPWKNQLSE MVQPSGGPAE DQDMLGEESS LGKPAMLHLP 
SEQGTPETLQ RCLEENQELR DAIRQSNQML RERCEELLHF QVSQREEKEF LMCKFQEARK 
LVERLSLEKL DLRSQREQAL KELEQLKKCQ QQMAEDKASV KAQVTSLLGE LQESQSRLEA 
ATKDRQALEG RIRAVSEQVR QLESEREVLQ QQHSVQVDQL RMQNQSVEAA LRMERQAASE 
EKRKLAQLQA AYHQLFQDYD SHIKSSKGMQ LEDLRQQLQQ AEEALVAKQE LIDKLKEEAE 
QHKIVMETVP VLKAQADIYK ADFQAERHAR EKLVEKKEYL QEQLEQLQRE FNKLKVGCHE 
SARIEDMRKR HVETPQPPLL PAPAHHSFHL ALSNQRRSPP EEPPDFCCPK CQYQAPDMDT 
LQIHVMECIE

Genular Protein ID: 3625163408

Symbol: E9Q2Y3_MOUSE

Name: N/A

UniProtKB Accession Codes:

E9Q2Y3

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 424
Mass: 49367
Checksum: 9612EBFB4826FC8E
Sequence:

MRCLENGTLS CWMNKHPWKN QLSEMVQPSG GPAEDQDMLG EESSLGKPAM LHLPSEQGTP 
ETLQRCLEEN QELRDAIRQS NQMLRERCEE LLHFQVSQRE EKEFLMCKFQ EARKLVERLS 
LEKLDLRSQR EQALKELEQL KKCQQQMAED KASVKAQVTS LLGELQESQS RLEAATKDRQ 
ALEGRIRAVS EQVRQLESER EVLQQQHSVQ VDQLRMQNQS VEAALRMERQ AASEEKRKLA 
QLQAAYHQLF QDYDSHIKSS KGMQLEDLRQ QLQQAEEALV AKQELIDKLK EEAEQHKIVM 
ETVPVLKAQA DIYKADFQAE RHAREKLVEK KEYLQEQLEQ LQREFNKLKV GCHESARIED 
MRKRHVETPQ PPLLPAPAHH SFHLALSNQR RSPPEEPPDF CCPKCQYQAP DMDTLQIHVM 
ECIE

Genular Protein ID: 3819578145

Symbol: Q8VC91_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8VC91

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 411
Mass: 47844
Checksum: FCF9EF0C6123A12E
Sequence:

MNKHPWKNQL SEMVQPSGGP AEDQDMLGEE SSLGKPAMLH LPSEQGTPET LQRCLEENQE 
LRDAIRQSNQ MLRERCEELL HFQVSQREEK EFLMCKFQEA RKLVERLSLE KLDLRSQREQ 
ALKELEQLKK CQQMAEDKAS VKAQVTSLLG ELQESQSRLE AATKDRQALE GRIRAVSEQV 
RQLESEREVL QQQHSVQVDQ LRMQNQSVEA ALRMERQAAS EEKRKLAQLQ AAYHQLFQDY 
DSHIKSSKGM QLEDLRQQLQ QAEEALVAKQ ELIDKLKEEA EQHKIVMETV PVLKAQADIY 
KADFQAERHA REKLVEKKEY LQEQLEQLQR EFNKLKVGCH ESARIEDMRK RHVETPQPPL 
LPAPAHHSFH LALSNQRRSP PEEPPDFCCP KCQYQAPDMD TLQIHVMECI E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ikbkg

Associated with

Other Information

Complementation cloning of NEMO, a component of the I-kappaB kinase complex essential for NF-kappaB activation. PubMed ID: 9657155

Human-mouse comparative sequence analysis of the NEMO gene reveals an alternative promoter within the neighboring G6PD gene. PubMed ID: 11410370

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. PubMed ID: 9891086

Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. PubMed ID: 9927690

Role of ikkgamma/nemo in assembly of the IkappaB kinase complex. PubMed ID: 11080499

Regulation of Ikappa B kinase (IKK)gamma /NEMO function by IKKbeta -mediated phosphorylation. PubMed ID: 11971901

Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. PubMed ID: 12133833

ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. PubMed ID: 16684768

Identification of TRAF6-dependent NEMO polyubiquitination sites through analysis of a new NEMO mutation causing incontinentia pigmenti. PubMed ID: 17728323

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. PubMed ID: 20622870

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. PubMed ID: 31519886

Negative regulation of NEMO signaling by the ubiquitin E3 ligase MARCH2. PubMed ID: 32935379

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. PubMed ID: 19303852

DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. PubMed ID: 19854204

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 9657155

PubMed ID: 11410370

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 9891086

PubMed ID: 9927690

PubMed ID: 11080499

PubMed ID: 11971901

PubMed ID: 12133833

PubMed ID: 16684768

PubMed ID: 17728323

PubMed ID: 21183079

PubMed ID: 20622870

PubMed ID: 31519886

PubMed ID: 32935379

PubMed ID: 19303852

PubMed ID: 19854204

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 19468303

PubMed ID: 21183079

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 15489334

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 21183079