Details for: Il10

Gene ID: 16153

Symbol: Il10

Ensembl ID: ENSMUSG00000016529

Description: interleukin 10

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-10 signaling
    (R-MMU-6783783)
  • Signaling by interleukins
    (R-MMU-449147)
  • Branching involved in labyrinthine layer morphogenesis
    (GO:0060670)
  • Cellular response to hepatocyte growth factor stimulus
    (GO:0035729)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Cytokine activity
    (GO:0005125)
  • Defense response to bacterium
    (GO:0042742)
  • Defense response to protozoan
    (GO:0042832)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Immune response
    (GO:0006955)
  • Interleukin-10 receptor binding
    (GO:0005141)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of autophagy
    (GO:0010507)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002875)
  • Negative regulation of cytokine activity
    (GO:0060302)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of heterotypic cell-cell adhesion
    (GO:0034115)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of membrane protein ectodomain proteolysis
    (GO:0051045)
  • Negative regulation of mhc class ii biosynthetic process
    (GO:0045347)
  • Negative regulation of myeloid dendritic cell activation
    (GO:0030886)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    (GO:1903377)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Positive regulation of b cell apoptotic process
    (GO:0002904)
  • Positive regulation of cell cycle
    (GO:0045787)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of plasma cell differentiation
    (GO:1900100)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of sprouting angiogenesis
    (GO:1903672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein dimerization activity
    (GO:0046983)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of response to wounding
    (GO:1903034)
  • Regulation of synapse organization
    (GO:0050807)
  • Response to glucocorticoid
    (GO:0051384)
  • Response to molecule of bacterial origin
    (GO:0002237)

Other Information

Genular Protein ID: 3662160622

Symbol: IL10_MOUSE

Name: Interleukin-10

UniProtKB Accession Codes:

P18893 Q0VBJ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 GO 57 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2161559

Title: Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

PubMed ID: 2161559

DOI: 10.1126/science.2161559

PubMed ID: 1350294

Title: Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

PubMed ID: 1350294

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8364028

Title: Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10.

PubMed ID: 8364028

DOI: 10.1021/bi00085a011

PubMed ID: 28473584

Title: Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages.

PubMed ID: 28473584

DOI: 10.1126/science.aal3535

Sequence Information:

  • Length: 178
  • Mass: 20641
  • Checksum: 9A283E6FFC99312B
  • Sequence:
    • MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 
LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLGEKLKTLR 
MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ DQGVYKAMNE FDIFINCIEA YMMIKMKS

Genular Protein ID: 1663923539

Symbol: Q3U879_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U879

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 1 RefSeq 1 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 178
  • Mass: 20671
  • Checksum: 9A35E3AFE144F12B
  • Sequence:
    • MPGSALLCCL LLLTGMRISR GQYSREDNNC THFPVGQSHM LLELRTAFSQ VKTFFQTKDQ 
LDNILLTDSL MQDFKGYLGC QALSEMIQFY LVEVMPQAEK HGPEIKEHLN SLSEKLKTLR 
MRLRRCHRFL PCENKSKAVE QVKSDFNKLQ DQGVYKAMNE FDIFINCIEA YMMIKMKS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.