Genular: Defining Cellular Identity and Function

Details for: Il12a

Gene ID: 16159

Symbol: Il12a

Ensembl ID: ENSMUSG00000027776

Description: interleukin 12a

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-12 family signaling
(R-MMU-447115)
Interleukin-12 signaling
(R-MMU-9020591)
Interleukin-35 signalling
(R-MMU-8984722)
Signaling by interleukins
(R-MMU-449147)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cell surface
(GO:0009986)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to virus
(GO:0098586)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Defense response to protozoan
(GO:0042832)
Endoplasmic reticulum lumen
(GO:0005788)
Endosome lumen
(GO:0031904)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Golgi lumen
(GO:0005796)
Growth factor activity
(GO:0008083)
Immune response
(GO:0006955)
Interleukin-12 beta subunit binding
(GO:0042163)
Interleukin-12 complex
(GO:0043514)
Interleukin-12 receptor binding
(GO:0005143)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-27 binding
(GO:0045513)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of vascular endothelial growth factor signaling pathway
(GO:1900747)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of lymphocyte proliferation
(GO:0050671)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Positive regulation of natural killer cell activation
(GO:0032816)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
(GO:0002860)
Positive regulation of nk t cell activation
(GO:0051135)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Response to lipopolysaccharide
(GO:0032496)
Response to uv-b
(GO:0010224)
T-helper 1 cell activation
(GO:0035711)
T-helper 1 cell cytokine production
(GO:0035744)
T cell proliferation
(GO:0042098)
Type ii interferon production
(GO:0032609)

Other Information

Proteins

Interleukin-12 subunit alpha
F8WI71_MOUSE

Genular Protein ID: 3541012862

Symbol: IL12A_MOUSE

Name: Interleukin-12 subunit alpha

UniProtKB Accession Codes:

P43431

Database IDs:

Citations:

PubMed ID: 1350290

Title: Cloning and expression of murine IL-12.

PubMed ID: 1350290

PubMed ID: 8647196

Title: Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

PubMed ID: 8647196

DOI: 10.1002/eji.1830260606

PubMed ID: 8557982

Title: Molecular cloning and characterization of murine IL-12 genes.

PubMed ID: 8557982

PubMed ID: 8766560

Title: Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response.

PubMed ID: 8766560

DOI: 10.1002/eji.1830260722

PubMed ID: 18033300

Title: The inhibitory cytokine IL-35 contributes to regulatory T-cell function.

PubMed ID: 18033300

DOI: 10.1038/nature06306

PubMed ID: 30197594

Title: Interleukin-35 attenuates D-Galactosamine/Lipopolysaccharide-induced liver injury via enhancing interleukin-10 production in Kupffer cells.

PubMed ID: 30197594

DOI: 10.3389/fphar.2018.00959

PubMed ID: 34374750

Title: Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.

PubMed ID: 34374750

DOI: 10.1093/ecco-jcc/jjab144

Sequence Information:

Length: 215
Mass: 24179
Checksum: 56845B9B66D35A53
Sequence:

MCQSRYLLFL ATLALLNHLS LARVIPVSGP ARCLSQSRNL LKTTDDMVKT AREKLKHYSC 
TAEDIDHEDI TRDQTSTLKT CLPLELHKNE SCLATRETSS TTRGSCLPPQ KTSLMMTLCL 
GSIYEDLKMY QTEFQAINAA LQNHNHQQII LDKGMLVAID ELMQSLNHNG ETLRQKPPVG 
EADPYRVKMK LCILLHAFST RVVTINRVMG YLSSA

Genular Protein ID: 3989917220

Symbol: F8WI71_MOUSE

Name: N/A

UniProtKB Accession Codes:

F8WI71

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 236
Mass: 26204
Checksum: 0E18CC4BA02EC5B6
Sequence:

MVSVPTASPS ASSSSSQCRS SMCQSRYLLF LATLALLNHL SLARVIPVSG PARCLSQSRN 
LLKTTDDMVK TAREKLKHYS CTAEDIDHED ITRDQTSTLK TCLPLELHKN ESCLATRETS 
STTRGSCLPP QKTSLMMTLC LGSIYEDLKM YQTEFQAINA ALQNHNHQQI ILDKGMLVAI 
DELMQSLNHN GETLRQKPPV GEADPYRVKM KLCILLHAFS TRVVTINRVM GYLSSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il12a

Associated with

Other Information

Cloning and expression of murine IL-12. PubMed ID: 1350290

Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes. PubMed ID: 8647196

Molecular cloning and characterization of murine IL-12 genes. PubMed ID: 8557982

Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. PubMed ID: 8766560

The inhibitory cytokine IL-35 contributes to regulatory T-cell function. PubMed ID: 18033300

Interleukin-35 attenuates D-Galactosamine/Lipopolysaccharide-induced liver injury via enhancing interleukin-10 production in Kupffer cells. PubMed ID: 30197594

Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation. PubMed ID: 34374750

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303