Details for: DAXX

Gene ID: 1616

Symbol: DAXX

Ensembl ID: ENSG00000204209

Description: death domain associated protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.51
    Marker Score: 7175
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.02
    Marker Score: 1807
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.54
    Marker Score: 6651
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.21
    Marker Score: 7719
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.2
    Marker Score: 16163
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.09
    Marker Score: 3244
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.09
    Marker Score: 4202
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.07
    Marker Score: 728
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11929
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.05
    Marker Score: 638
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1804
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.98
    Marker Score: 1030
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1423
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.96
    Marker Score: 2707
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.96
    Marker Score: 2033
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.96
    Marker Score: 535
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.93
    Marker Score: 875
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 430
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.91
    Marker Score: 9008
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.89
    Marker Score: 753
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.89
    Marker Score: 3630
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.88
    Marker Score: 828
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.88
    Marker Score: 502
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5224
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.86
    Marker Score: 900
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.85
    Marker Score: 617
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.84
    Marker Score: 897
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.84
    Marker Score: 844
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.84
    Marker Score: 886
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4752
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.83
    Marker Score: 625
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.82
    Marker Score: 1455
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.82
    Marker Score: 401
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.81
    Marker Score: 1075
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.81
    Marker Score: 1311
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.81
    Marker Score: 1984
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.8
    Marker Score: 1661
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.79
    Marker Score: 436
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.78
    Marker Score: 586
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.77
    Marker Score: 2132
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.77
    Marker Score: 2086.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.75
    Marker Score: 1276
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.75
    Marker Score: 454
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.74
    Marker Score: 1330
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.74
    Marker Score: 321
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.74
    Marker Score: 766
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.73
    Marker Score: 1081
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.73
    Marker Score: 809
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.73
    Marker Score: 2293
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.73
    Marker Score: 525
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.73
    Marker Score: 386
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.72
    Marker Score: 8358.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.71
    Marker Score: 221
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.71
    Marker Score: 2791
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.71
    Marker Score: 227
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.7
    Marker Score: 246
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7
    Marker Score: 491
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.69
    Marker Score: 1582
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.69
    Marker Score: 234
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.69
    Marker Score: 1133
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.69
    Marker Score: 199
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.69
    Marker Score: 975
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.69
    Marker Score: 2010
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 625
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.68
    Marker Score: 387
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.68
    Marker Score: 162
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.68
    Marker Score: 1657
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2849
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.68
    Marker Score: 199
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.67
    Marker Score: 701
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.67
    Marker Score: 457
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.67
    Marker Score: 630
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.67
    Marker Score: 4260
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.66
    Marker Score: 591
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.66
    Marker Score: 519
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.66
    Marker Score: 163
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.65
    Marker Score: 322
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.65
    Marker Score: 22035
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.64
    Marker Score: 202
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.64
    Marker Score: 145
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.64
    Marker Score: 755
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.64
    Marker Score: 406
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 425
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.64
    Marker Score: 429
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.64
    Marker Score: 563
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.64
    Marker Score: 1097
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.64
    Marker Score: 319
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.64
    Marker Score: 169
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.64
    Marker Score: 428
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.64
    Marker Score: 1496.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 794.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.63
    Marker Score: 363

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Other Information

**Key characteristics:** - DAXX is a protein that is encoded by the DAXX gene. - It is a transmembrane protein with a death domain and a cytoplasmic tail. - It is involved in the regulation of telomere length through the alternative lengthening of telomeres (alt) pathway. - It also plays a role in cell cycle regulation, chromosome maintenance, and disease. **Pathways and functions:** - The alt pathway is a mechanism that maintains telomere length by regulating the expression of genes that are involved in telomere replication and repair. - DAXX is a key regulator of the alt pathway. It acts as a negative regulator of the pathway by binding to the TP53 tumor suppressor protein and inhibiting its interaction with the Forkhead box protein FHL1. - Without DAXX, the TP53 protein would be able to interact with FHL1 and promote the expression of genes that are involved in telomere maintenance. - By inhibiting the TP53/FHL1 pathway, DAXX ensures that telomeres are maintained at normal lengths. **Clinical significance:** - Mutations in the DAXX gene have been linked to a number of human diseases, including cancer and developmental disorders. - In cancer, mutations in DAXX can lead to the activation of oncogenes and the formation of tumors. - Targeting DAXX has been investigated as a potential therapeutic strategy for cancer. **Additional information:** - The DAXX gene is also involved in the regulation of viral infection pathways. - It is a key regulator of the innate immune response to HCMV infection. - Mutations in the DAXX gene have also been linked to the pathogenesis of autoimmune diseases, such as lupus and rheumatoid arthritis.

Genular Protein ID: 655863942

Symbol: DAXX_HUMAN

Name: Death domain-associated protein 6

UniProtKB Accession Codes:

Q9UER7 B4E1I3 F5ANJ6 F5ANJ7 F5H082 O14747 O15141 O15208 Q5STK9 Q9BWI3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 24 EPD 1 Ensembl 19 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 14 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 3 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 2 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9215629

Title: Daxx, a novel Fas-binding protein that activates JNK and apoptosis.

PubMed ID: 9215629

DOI: 10.1016/s0092-8674(00)80294-9

PubMed ID: 9407001

Title: Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.

PubMed ID: 9407001

DOI: 10.1089/dna.1997.16.1289

PubMed ID: 9645950

Title: Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death.

PubMed ID: 9645950

DOI: 10.1242/jcs.111.14.2029

PubMed ID: 9545376

Title: TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC.

PubMed ID: 9545376

DOI: 10.1006/jmbi.1998.1637

PubMed ID: 10698492

Title: EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes.

PubMed ID: 10698492

DOI: 10.1038/sj.onc.1203385

PubMed ID: 21482821

Title: Daxx-beta and Daxx-gamma, two novel splice variants of the transcriptional co-repressor Daxx.

PubMed ID: 21482821

DOI: 10.1074/jbc.m110.196311

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10393185

Title: The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx.

PubMed ID: 10393185

DOI: 10.1093/emboj/18.13.3702

PubMed ID: 10684855

Title: Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis.

PubMed ID: 10684855

DOI: 10.1084/jem.191.4.631

PubMed ID: 10669754

Title: Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.

PubMed ID: 10669754

DOI: 10.1128/mcb.20.5.1784-1796.2000

PubMed ID: 11003656

Title: Inhibition of Daxx-mediated apoptosis by heat shock protein 27.

PubMed ID: 11003656

DOI: 10.1128/mcb.20.20.7602-7612.2000

PubMed ID: 11495919

Title: Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm.

PubMed ID: 11495919

DOI: 10.1074/jbc.m105928200

PubMed ID: 11483955

Title: TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation.

PubMed ID: 11483955

DOI: 10.1038/35087019

PubMed ID: 12150977

Title: Modification of Daxx by small ubiquitin-related modifier-1.

PubMed ID: 12150977

DOI: 10.1016/s0006-291x(02)00699-x

PubMed ID: 11842083

Title: The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.

PubMed ID: 11842083

DOI: 10.1074/jbc.m110294200

PubMed ID: 11948183

Title: Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.

PubMed ID: 11948183

DOI: 10.1074/jbc.m200633200

PubMed ID: 12140263

Title: Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek.

PubMed ID: 12140263

DOI: 10.1242/jcs.115.16.3319

PubMed ID: 11907324

Title: Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.

PubMed ID: 11907324

DOI: 10.1099/0022-1317-83-4-759

PubMed ID: 14678985

Title: HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells.

PubMed ID: 14678985

PubMed ID: 12968034

Title: Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization.

PubMed ID: 12968034

DOI: 10.1074/jbc.m213201200

PubMed ID: 12529400

Title: Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity.

PubMed ID: 12529400

DOI: 10.1128/mcb.23.3.950-960.2003

PubMed ID: 12953102

Title: The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies.

PubMed ID: 12953102

DOI: 10.1073/pnas.1937626100

PubMed ID: 14557665

Title: Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by DAXX.

PubMed ID: 14557665

DOI: 10.1128/jvi.77.21.11809-11821.2003

PubMed ID: 15240113

Title: Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.

PubMed ID: 15240113

DOI: 10.1016/j.bbrc.2004.06.022

PubMed ID: 14990586

Title: A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein.

PubMed ID: 14990586

DOI: 10.1074/jbc.m401321200

PubMed ID: 15364927

Title: Negative regulation of p53 functions by Daxx and the involvement of MDM2.

PubMed ID: 15364927

DOI: 10.1074/jbc.m406743200

PubMed ID: 15016915

Title: DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.

PubMed ID: 15016915

DOI: 10.1073/pnas.0304768101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16524876

Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.

PubMed ID: 16524876

DOI: 10.1074/jbc.m600204200

PubMed ID: 17081986

Title: Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors.

PubMed ID: 17081986

DOI: 10.1016/j.molcel.2006.10.019

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 16845383

Title: Critical role for Daxx in regulating Mdm2.

PubMed ID: 16845383

DOI: 10.1038/ncb1442

PubMed ID: 17210684

Title: Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.

PubMed ID: 17210684

DOI: 10.1158/0008-5472.can-06-1671

PubMed ID: 18566590

Title: The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.

PubMed ID: 18566590

DOI: 10.1038/emboj.2008.115

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 17942542

Title: Nuclear domain 10 components promyelocytic leukemia protein and hDaxx independently contribute to an intrinsic antiviral defense against human cytomegalovirus infection.

PubMed ID: 17942542

DOI: 10.1128/jvi.01685-07

PubMed ID: 18922870

Title: Human cytomegalovirus protein pp71 displaces the chromatin-associated factor ATRX from nuclear domain 10 at early stages of infection.

PubMed ID: 18922870

DOI: 10.1128/jvi.01215-08

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20153724

Title: Daxx is reciprocally regulated by Mdm2 and Hausp.

PubMed ID: 20153724

DOI: 10.1016/j.bbrc.2010.02.051

PubMed ID: 20504901

Title: The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.

PubMed ID: 20504901

DOI: 10.1101/gad.566910

PubMed ID: 20444888

Title: Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection.

PubMed ID: 20444888

DOI: 10.1128/jvi.02231-09

PubMed ID: 20651253

Title: Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

PubMed ID: 20651253

DOI: 10.1073/pnas.1008850107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23222847

Title: DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin.

PubMed ID: 23222847

DOI: 10.1101/gr.142703.112

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24200965

Title: Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization.

PubMed ID: 24200965

DOI: 10.4161/cc.26988

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25275136

Title: Viral reprogramming of the Daxx histone H3.3 chaperone during early Epstein-Barr virus infection.

PubMed ID: 25275136

DOI: 10.1128/jvi.01895-14

PubMed ID: 24530302

Title: Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.

PubMed ID: 24530302

DOI: 10.1016/j.molcel.2014.01.018

PubMed ID: 27211601

Title: SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

PubMed ID: 27211601

DOI: 10.1038/srep26509

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21134643

Title: Structural characterization of the DAXX N-terminal helical bundle domain and its complex with Rassf1C.

PubMed ID: 21134643

DOI: 10.1016/j.str.2010.09.016

PubMed ID: 20927612

Title: NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx.

PubMed ID: 20927612

DOI: 10.1007/s12104-010-9271-4

PubMed ID: 23142979

Title: Structure of the variant histone H3.3-H4 heterodimer in complex with its chaperone DAXX.

PubMed ID: 23142979

DOI: 10.1038/nsmb.2439

PubMed ID: 23075851

Title: DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.

PubMed ID: 23075851

DOI: 10.1038/nature11608

Sequence Information:

  • Length: 740
  • Mass: 81373
  • Checksum: 1B309ADDAA878040
  • Sequence:
    • MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK 
LENEKLFEEF LELCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP 
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR 
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC 
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH 
SLGLPRQQLQ LMAQDAFRDV GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR 
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS 
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE 
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP 
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV 
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG 
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC 
KTSVATQCDP EEIIVLSDSD

Genular Protein ID: 646257007

Symbol: B4E1C1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E1C1

Database IDs:

ARBA 22 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 10 Gene3D 2 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 4 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 PharmGKB 1 Proteomes 2 RefSeq 1 SAM 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 752
  • Mass: 82876
  • Checksum: 564F283805B26479
  • Sequence:
    • MRGSENCGEG RLERRFLSII VLDDDDEDEA AAQPGPSHPL PNAASPGAEA PSSSEPHGAR 
GSSSSGGKKC YKLENEKLFE EFLELCKMQT ADHPEVVPFL YNRQQRAHSL FLASAEFCNI 
LSRVLSRARS RPAKLYVYIN ELCTVLKAHS AKKKLNLAPA ATTSNEPSGN NPPTHLSLDP 
TNAENTASQS PRTRGSRRQI QRLEQLLALY VAEIRRLQEK ELDLSELDDP DSAYLQEARL 
KRKLIRLFGR LCELKDCSSL TGRVIEQRIP YRGTRYPEVN RRIERLINKP GPDTFPDYGD 
VLRAVEKAAA RHSLGLPRQQ LQLMAQDAFR DVGIRLQERR HLDLIYNFGC HLTDDYRPGV 
DPALSDPVLA RRLRENRSLA MSRLDEVISK YAMLQDKSEE GERKKRRARL QGTSSHSADT 
PEASLDSGEG PSGMASQGCP SASRAETDDE DDEESDEEEE EEEEEEEEEA TDSEEEEDLE 
QMQEGQEDDE EEDEEEEAAA GKDGDKSPMS SLQISNEKNL EPGKQISRSS GEQQNKGRIV 
SPSLLSEEPL APSSIDAESN GEQPEELTLE EESPVSQLFE LEIEALPLDT PSSVETDISS 
SRKQSEEPFT TVLENGAGMV SSTSFNGGVS PHNWGDSGPP CKKSRKEKKQ TGSGPLGNSY 
VERQRSVHEK NGKKICTLPS PPSPLASLAP VADSSTRVDS PSHGLVTSSL CIPSPARLSQ 
TPHSQPPRPG TCKTSVATQC DPEEIIVLSD SD

Genular Protein ID: 35241425

Symbol: Q53F85_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53F85

Database IDs:

ARBA 22 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 8 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 740
  • Mass: 81228
  • Checksum: 046B3A2A3BAC65E7
  • Sequence:
    • MATANSIIVL DDDDEDEAAA QPGPSHPLPN AASPGAEAPS SSEPHGARGS SSSGGKKCYK 
LENEKLCEEF LGLCKMQTAD HPEVVPFLYN RQQRAHSLFL ASAEFCNILS RVLSRARSRP 
AKLYVYINEL CTVLKAHSAK KKLNLAPAAT TSNEPSGNNP PTHLSLDPTN AENTASQSPR 
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS AYLQEARLKR KLIRLFGRLC 
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DTFPDYGDVL RAVEKAAARH 
SLGLPRQQLQ LMAQDAFRDA GIRLQERRHL DLIYNFGCHL TDDYRPGVDP ALSDPVLARR 
LRENRSLAMS RLDEVISKYA MLQDKSEEGE RKKRRARLQG TSSHSADTPE ASLDSGEGPS 
GMASQGCPSA SRAETDDEDD EESDEEEEEE EEEEEEEATD SEEEEDLEQM QEGQEDDEEE 
DEEEEAAAGK DGDKSPMSSL QISNEKNLEP GKQISRSSGE QQNKGRIVSP SLLSEEPLAP 
SSIDAESNGE QPEELTLEEE SPVSQLFELE IEALPLDTPS SVETDISSSR KQSEEPFTTV 
LENGAGMVSS TSFNGGVSPH NWGDSGPPCK KSRKEKKQTG SGPLGNSYVE RQRSVHEKNG 
KKICTLPSPP SPLASLAPVA DSSTRVDSPS HGLVTSSLCI PSPARLSQTP HSQPPRPGTC 
KTSVATQCDP EEIIVLSDSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.