Details for: Il12b

Gene ID: 16160

Symbol: Il12b

Ensembl ID: ENSMUSG00000004296

Description: interleukin 12b

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-12 family signaling
    (R-MMU-447115)
  • Interleukin-12 signaling
    (R-MMU-9020591)
  • Interleukin-23 signaling
    (R-MMU-9020933)
  • Signaling by interleukins
    (R-MMU-449147)
  • Cell migration
    (GO:0016477)
  • Cell population proliferation
    (GO:0008283)
  • Cell surface
    (GO:0009986)
  • Cell surface receptor signaling pathway
    (GO:0007166)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor activity
    (GO:0004896)
  • Cytokine receptor binding
    (GO:0005126)
  • Cytoplasm
    (GO:0005737)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to protozoan
    (GO:0042832)
  • Defense response to virus
    (GO:0051607)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Endosome lumen
    (GO:0031904)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Golgi lumen
    (GO:0005796)
  • Growth factor activity
    (GO:0008083)
  • Identical protein binding
    (GO:0042802)
  • Immunoglobulin mediated immune response
    (GO:0016064)
  • Interleukin-12 alpha subunit binding
    (GO:0042164)
  • Interleukin-12 complex
    (GO:0043514)
  • Interleukin-12-mediated signaling pathway
    (GO:0035722)
  • Interleukin-23 complex
    (GO:0070743)
  • Interleukin-23 receptor binding
    (GO:0045519)
  • Membrane
    (GO:0016020)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell activation involved in immune response
    (GO:0002323)
  • Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    (GO:1903588)
  • Negative regulation of inflammatory response to antigenic stimulus
    (GO:0002862)
  • Negative regulation of interleukin-10 production
    (GO:0032693)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of smooth muscle cell proliferation
    (GO:0048662)
  • Negative regulation of vascular endothelial growth factor signaling pathway
    (GO:1900747)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of activation of janus kinase activity
    (GO:0010536)
  • Positive regulation of cell adhesion
    (GO:0045785)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of lymphocyte proliferation
    (GO:0050671)
  • Positive regulation of mononuclear cell proliferation
    (GO:0032946)
  • Positive regulation of natural killer cell activation
    (GO:0032816)
  • Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
    (GO:0002860)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of nk t cell activation
    (GO:0051135)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of smooth muscle cell apoptotic process
    (GO:0034393)
  • Positive regulation of t-helper 1 type immune response
    (GO:0002827)
  • Positive regulation of t cell mediated cytotoxicity
    (GO:0001916)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Regulation of tyrosine phosphorylation of stat protein
    (GO:0042509)
  • Response to organic substance
    (GO:0010033)
  • Response to uv-b
    (GO:0010224)
  • T-helper 1 cell cytokine production
    (GO:0035744)
  • T-helper cell differentiation
    (GO:0042093)
  • T cell proliferation
    (GO:0042098)
  • Type ii interferon production
    (GO:0032609)

Other Information

Genular Protein ID: 3059859357

Symbol: IL12B_MOUSE

Name: Interleukin-12 subunit beta

UniProtKB Accession Codes:

P43432 Q9QUM1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ComplexPortal 4 DIP 1 DNASU 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 65 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1350290

Title: Cloning and expression of murine IL-12.

PubMed ID: 1350290

PubMed ID: 8647196

Title: Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes.

PubMed ID: 8647196

DOI: 10.1002/eji.1830260606

PubMed ID: 10438970

Title: Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis.

PubMed ID: 10438970

PubMed ID: 11114383

Title: Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

PubMed ID: 11114383

DOI: 10.1016/s1074-7613(00)00070-4

PubMed ID: 34374750

Title: Non-autophagy Role of Atg5 and NBR1 in Unconventional Secretion of IL-12 Prevents Gut Dysbiosis and Inflammation.

PubMed ID: 34374750

DOI: 10.1093/ecco-jcc/jjab144

Sequence Information:

  • Length: 335
  • Mass: 38235
  • Checksum: 19E4FA5EF0CFC82A
  • Sequence:
    • MCPQKLTISW FAIVLLVSPL MAMWELEKDV YVVEVDWTPD APGETVNLTC DTPEEDDITW 
TSDQRHGVIG SGKTLTITVK EFLDAGQYTC HKGGETLSHS HLLLHKKENG IWSTEILKNF 
KNKTFLKCEA PNYSGRFTCS WLVQRNMDLK FNIKSSSSSP DSRAVTCGMA SLSAEKVTLD 
QRDYEKYSVS CQEDVTCPTA EETLPIELAL EARQQNKYEN YSTSFFIRDI IKPDPPKNLQ 
MKPLKNSQVE VSWEYPDSWS TPHSYFSLKF FVRIQRKKEK MKETEEGCNQ KGAFLVEKTS 
TEVQCKGGNV CVQAQDRYYN SSCSKWACVP CRVRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.