Details for: Il13

Gene ID: 16163

Symbol: Il13

Ensembl ID: ENSMUSG00000020383

Description: interleukin 13

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-MMU-6785807)
  • Signaling by interleukins
    (R-MMU-449147)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor binding
    (GO:0005126)
  • Cytoplasm
    (GO:0005737)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-13 receptor binding
    (GO:0005144)
  • Macrophage activation
    (GO:0042116)
  • Microglial cell activation
    (GO:0001774)
  • Negative regulation of complement-dependent cytotoxicity
    (GO:1903660)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of transforming growth factor beta production
    (GO:0071635)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of connective tissue growth factor production
    (GO:0032723)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of macrophage activation
    (GO:0043032)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of monoatomic ion transport
    (GO:0043270)
  • Positive regulation of pancreatic stellate cell proliferation
    (GO:2000231)
  • Positive regulation of protein secretion
    (GO:0050714)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protein binding
    (GO:0005515)
  • Regulation of proton transport
    (GO:0010155)
  • Response to nicotine
    (GO:0035094)

Other Information

Genular Protein ID: 2761278962

Symbol: IL13_MOUSE

Name: Interleukin-13

UniProtKB Accession Codes:

P20109

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 1 GO 31 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2521353

Title: A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors, and indicators of various activation processes.

PubMed ID: 2521353

PubMed ID: 8871614

Title: Impaired IL-13-mediated functions of macrophages in STAT6-deficient mice.

PubMed ID: 8871614

PubMed ID: 15361238

Title: Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites.

PubMed ID: 15361238

DOI: 10.1111/j.0105-2896.2004.00192.x

PubMed ID: 25847241

Title: Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

PubMed ID: 25847241

DOI: 10.1074/jbc.m114.622126

PubMed ID: 29305434

Title: Modulation of the IL-33/IL-13 Axis in Obesity by IL-13Ralpha2.

PubMed ID: 29305434

DOI: 10.4049/jimmunol.1701256

PubMed ID: 34795444

Title: Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TH2 and inhibit TH17 cell polarization.

PubMed ID: 34795444

DOI: 10.1038/s41590-021-01067-0

PubMed ID: 34789557

Title: IL-13 Controls IL-33 Activity through Modulation of ST2.

PubMed ID: 34789557

DOI: 10.4049/jimmunol.2100655

Sequence Information:

  • Length: 131
  • Mass: 14108
  • Checksum: 954F93F105713FED
  • Sequence:
    • MALWVTAVLA LACLGGLAAP GPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD 
LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS 
YTKQLFRHGP F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.