Details for: Il17a

Gene ID: 16171

Symbol: Il17a

Ensembl ID: ENSMUSG00000025929

Description: interleukin 17A

Associated with

  • Adaptive immune response
    (GO:0002250)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cytokine activity
    (GO:0005125)
  • Defense response to fungus
    (GO:0050832)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibroblast activation
    (GO:0072537)
  • Gene expression
    (GO:0010467)
  • Granulocyte migration
    (GO:0097530)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Interleukin-17-mediated signaling pathway
    (GO:0097400)
  • Interleukin-17a-mediated signaling pathway
    (GO:0038173)
  • Intestinal epithelial structure maintenance
    (GO:0060729)
  • Keratinocyte differentiation
    (GO:0030216)
  • Keratinocyte proliferation
    (GO:0043616)
  • Negative regulation of inflammatory response to wounding
    (GO:0106015)
  • Notch signaling pathway
    (GO:0007219)
  • Positive regulation of antimicrobial peptide production
    (GO:0002225)
  • Positive regulation of bicellular tight junction assembly
    (GO:1903348)
  • Positive regulation of chemokine (c-x-c motif) ligand 1 production
    (GO:2000340)
  • Positive regulation of cytokine production involved in inflammatory response
    (GO:1900017)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-16 production
    (GO:0032739)
  • Positive regulation of interleukin-23 production
    (GO:0032747)
  • Positive regulation of osteoclast differentiation
    (GO:0045672)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Response to wounding
    (GO:0009611)

Other Information

Genular Protein ID: 1933056605

Symbol: IL17_MOUSE

Name: Interleukin-17A

UniProtKB Accession Codes:

Q62386 Q60971

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEMBL 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PIR 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 8877732

Title: Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells.

PubMed ID: 8877732

DOI: 10.1089/jir.1996.16.611

PubMed ID: 8654948

Title: Complete nucleotide sequence of the mouse CTLA8 gene.

PubMed ID: 8654948

DOI: 10.1016/0378-1119(95)00778-4

PubMed ID: 16200068

Title: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.

PubMed ID: 16200068

DOI: 10.1038/ni1261

PubMed ID: 16990136

Title: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

PubMed ID: 16990136

DOI: 10.1016/j.cell.2006.07.035

PubMed ID: 17470641

Title: Identification of an IL-17-producing NK1.1(neg) iNKT cell population involved in airway neutrophilia.

PubMed ID: 17470641

DOI: 10.1084/jem.20061551

PubMed ID: 17372004

Title: Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.

PubMed ID: 17372004

DOI: 10.4049/jimmunol.178.7.4466

PubMed ID: 17911633

Title: Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.

PubMed ID: 17911633

DOI: 10.4049/jimmunol.179.8.5462

PubMed ID: 18025225

Title: An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment.

PubMed ID: 18025225

DOI: 10.4049/jimmunol.179.11.7791

PubMed ID: 18157131

Title: Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice.

PubMed ID: 18157131

DOI: 10.1038/ni1552

PubMed ID: 19144317

Title: Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses.

PubMed ID: 19144317

DOI: 10.1016/j.immuni.2008.11.009

PubMed ID: 20364087

Title: IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.

PubMed ID: 20364087

DOI: 10.1172/jci40891

PubMed ID: 21946434

Title: A critical role of IL-17 in modulating the B-cell response during H5N1 influenza virus infection.

PubMed ID: 21946434

DOI: 10.1038/cmi.2011.38

PubMed ID: 23255360

Title: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection.

PubMed ID: 23255360

DOI: 10.4049/jimmunol.1202924

PubMed ID: 26431948

Title: Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability.

PubMed ID: 26431948

DOI: 10.1016/j.immuni.2015.09.003

PubMed ID: 27923703

Title: IL-17 Receptor Signaling in the Lung Epithelium Is Required for Mucosal Chemokine Gradients and Pulmonary Host Defense against K. pneumoniae.

PubMed ID: 27923703

DOI: 10.1016/j.chom.2016.10.003

PubMed ID: 26735852

Title: IL-17A Promotes Pulmonary B-1a Cell Differentiation via Induction of Blimp-1 Expression during Influenza Virus Infection.

PubMed ID: 26735852

DOI: 10.1371/journal.ppat.1005367

PubMed ID: 27795421

Title: Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance.

PubMed ID: 27795421

DOI: 10.1128/jvi.01529-16

PubMed ID: 28709803

Title: An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal gammadelta T Cells.

PubMed ID: 28709803

DOI: 10.1016/j.immuni.2017.06.014

Sequence Information:

  • Length: 158
  • Mass: 17490
  • Checksum: 3505C143435F4653
  • Sequence:
    • MSPGRASSVS LMLLLLLSLA ATVKAAAIIP QSSACPNTEA KDFLQNVKVN LKVFNSLGAK 
VSSRRPSDYL NRSTSPWTLH RNEDPDRYPS VIWEAQCRHQ RCVNAEGKLD HHMNSVLIQQ 
EILVLKREPE SCPFTFRVEK MLVGVGCTCV ASIVRQAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.