Details for: Il18

Gene ID: 16173

Symbol: Il18

Ensembl ID: ENSMUSG00000039217

Description: interleukin 18

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-1 family signaling
    (R-MMU-446652)
  • Interleukin-1 processing
    (R-MMU-448706)
  • Interleukin-18 signaling
    (R-MMU-9012546)
  • Programmed cell death
    (R-MMU-5357801)
  • Pyroptosis
    (R-MMU-5620971)
  • Regulated necrosis
    (R-MMU-5218859)
  • Signaling by interleukins
    (R-MMU-449147)
  • Angiogenesis
    (GO:0001525)
  • Apical plasma membrane
    (GO:0016324)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cholesterol homeostasis
    (GO:0042632)
  • Cytokine activity
    (GO:0005125)
  • Cytoplasm
    (GO:0005737)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Detection of mechanical stimulus involved in sensory perception of pain
    (GO:0050966)
  • Establishment of skin barrier
    (GO:0061436)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-6 production
    (GO:0032635)
  • Interleukin-18 receptor binding
    (GO:0045515)
  • Interleukin-18-mediated signaling pathway
    (GO:0035655)
  • Natural killer cell activation
    (GO:0030101)
  • Natural killer cell mediated cytotoxicity
    (GO:0042267)
  • Negative regulation of myoblast differentiation
    (GO:0045662)
  • Negative regulation of neutrophil apoptotic process
    (GO:0033030)
  • Negative regulation of peptidyl-tyrosine phosphorylation
    (GO:0050732)
  • Neutrophil activation
    (GO:0042119)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of blood vessel remodeling
    (GO:2000504)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of hepatocyte proliferation
    (GO:2000347)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Positive regulation of male germ cell proliferation
    (GO:2000256)
  • Positive regulation of natural killer cell proliferation
    (GO:0032819)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of nk t cell proliferation
    (GO:0051142)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of superoxide anion generation
    (GO:0032930)
  • Positive regulation of t-helper 1 cell cytokine production
    (GO:2000556)
  • Positive regulation of t-helper 2 cell differentiation
    (GO:0045630)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular permeability
    (GO:0043117)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cell adhesion
    (GO:0030155)
  • Response to hypoxia
    (GO:0001666)
  • Sleep
    (GO:0030431)
  • T-helper 1 cell cytokine production
    (GO:0035744)
  • T-helper 1 type immune response
    (GO:0042088)
  • Triglyceride homeostasis
    (GO:0070328)
  • Type ii interferon production
    (GO:0032609)

Other Information

Genular Protein ID: 3111960074

Symbol: IL18_MOUSE

Name: Interleukin-18

UniProtKB Accession Codes:

P70380

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 59 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7477296

Title: Cloning of a new cytokine that induces IFN-gamma production by T cells.

PubMed ID: 7477296

DOI: 10.1038/378088a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9022080

Title: Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.

PubMed ID: 9022080

DOI: 10.1172/jci119181

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26638072

Title: Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling.

PubMed ID: 26638072

DOI: 10.1016/j.cell.2015.10.048

PubMed ID: 26638073

Title: Epithelial IL-18 equilibrium controls barrier function in colitis.

PubMed ID: 26638073

DOI: 10.1016/j.cell.2015.10.072

PubMed ID: 30392956

Title: The NLRP6 inflammasome recognizes lipoteichoic acid and regulates Gram-positive pathogen infection.

PubMed ID: 30392956

DOI: 10.1016/j.cell.2018.09.047

Sequence Information:

  • Length: 192
  • Mass: 22135
  • Checksum: 8FED938473874D63
  • Sequence:
    • MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI NDQVLFVDKR 
QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV KDSKMSTLSC KNKIISFEEM 
DPPENIDDIQ SDLIFFQKRV PGHNKMEFES SLYEGHFLAC QKEDDAFKLI LKKKDENGDK 
SVMFTLTNLH QS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.