Genular: Defining Cellular Identity and Function

Details for: Il1a

Gene ID: 16175

Symbol: Il1a

Ensembl ID: ENSMUSG00000027399

Description: interleukin 1 alpha

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 processing
(R-MMU-448706)
Interleukin-1 signaling
(R-MMU-9020702)
Programmed cell death
(R-MMU-5357801)
Pyroptosis
(R-MMU-5620971)
Regulated necrosis
(R-MMU-5218859)
Signaling by interleukins
(R-MMU-449147)
Cell surface
(GO:0009986)
Cellular response to heat
(GO:0034605)
Cellular response to lipopolysaccharide
(GO:0071222)
Connective tissue replacement involved in inflammatory response wound healing
(GO:0002248)
Copper ion binding
(GO:0005507)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Cytosol
(GO:0005829)
Ectopic germ cell programmed cell death
(GO:0035234)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fever generation
(GO:0001660)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Interleukin-33 production
(GO:0072639)
Intracellular sodium ion homeostasis
(GO:0006883)
Keratinization
(GO:0031424)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of establishment of sertoli cell barrier
(GO:1904445)
Nucleus
(GO:0005634)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of immature t cell proliferation in thymus
(GO:0033092)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of neutrophil migration
(GO:1902624)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of steroid biosynthetic process
(GO:0010893)
Positive regulation of stress-activated mapk cascade
(GO:0032874)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of nitric-oxide synthase activity
(GO:0050999)
Response to copper ion
(GO:0046688)
Signal transduction
(GO:0007165)

Other Information

Proteins

Interleukin-1 alpha

Genular Protein ID: 2726073063

Symbol: IL1A_MOUSE

Name: Interleukin-1 alpha

UniProtKB Accession Codes:

P01582

Database IDs:

Citations:

PubMed ID: 6209582

Title: Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.

PubMed ID: 6209582

DOI: 10.1038/312458a0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3126184

Title: The precursor of interleukin-1 alpha is phosphorylated at residue serine 90.

PubMed ID: 3126184

DOI: 10.1016/s0021-9258(18)69027-1

PubMed ID: 1386364

Title: Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.

PubMed ID: 1386364

DOI: 10.1016/s0021-9258(19)49611-7

PubMed ID: 16256210

Title: Interleukin-1alphabeta gene-deficient mice show reduced nociceptive sensitivity in models of inflammatory and neuropathic pain but not post-operative pain.

PubMed ID: 16256210

DOI: 10.1016/j.bbr.2005.09.024

Sequence Information:

Length: 270
Mass: 31023
Checksum: 7F60AC4F330D5B11
Sequence:

MAKVPDLFED LKNCYSENED YSSAIDHLSL NQKSFYDASY GSLHETCTDQ FVSLRTSETS 
KMSNFTFKES RVTVSATSSN GKILKKRRLS FSETFTEDDL QSITHDLEET IQPRSAPYTY 
QSDLRYKLMK LVRQKFVMND SLNQTIYQDV DKHYLSTTWL NDLQQEVKFD MYAYSSGGDD 
SKYPVTLKIS DSQLFVSAQG EDQPVLLKEL PETPKLITGS ETDLIFFWKS INSKNYFTSA 
AYPELFIATK EQSRVHLARG LPSMTDFQIS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il1a

Associated with

Other Information

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. PubMed ID: 6209582

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The precursor of interleukin-1 alpha is phosphorylated at residue serine 90. PubMed ID: 3126184