Details for: Il1b

Gene ID: 16176

Symbol: Il1b

Ensembl ID: ENSMUSG00000027398

Description: interleukin 1 beta

Associated with

  • C-type lectin receptors (clrs)
    (R-MMU-5621481)
  • Clec7a (dectin-1) signaling
    (R-MMU-5607764)
  • Clec7a/inflammasome pathway
    (R-MMU-5660668)
  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Innate immune system
    (R-MMU-168249)
  • Interleukin-1 family signaling
    (R-MMU-446652)
  • Interleukin-1 processing
    (R-MMU-448706)
  • Interleukin-1 signaling
    (R-MMU-9020702)
  • Programmed cell death
    (R-MMU-5357801)
  • Pyroptosis
    (R-MMU-5620971)
  • Regulated necrosis
    (R-MMU-5218859)
  • Signaling by interleukins
    (R-MMU-449147)
  • Astrocyte activation
    (GO:0048143)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Ectopic germ cell programmed cell death
    (GO:0035234)
  • Fever generation
    (GO:0001660)
  • Hyaluronan biosynthetic process
    (GO:0030213)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Integrin binding
    (GO:0005178)
  • Interleukin-1 beta production
    (GO:0032611)
  • Interleukin-1 receptor binding
    (GO:0005149)
  • Interleukin-6 production
    (GO:0032635)
  • Jnk cascade
    (GO:0007254)
  • Macrophage cytokine production
    (GO:0010934)
  • Memory
    (GO:0007613)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of glucose transmembrane transport
    (GO:0010829)
  • Negative regulation of glutamate secretion
    (GO:0014050)
  • Negative regulation of insulin receptor signaling pathway
    (GO:0046627)
  • Negative regulation of lipid metabolic process
    (GO:0045833)
  • Negative regulation of map kinase activity
    (GO:0043407)
  • Negative regulation of neurogenesis
    (GO:0050768)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neutrophil chemotaxis
    (GO:0030593)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of astrocyte differentiation
    (GO:0048711)
  • Positive regulation of canonical nf-kappab signal transduction
    (GO:0043123)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of complement activation
    (GO:0045917)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of fever generation
    (GO:0031622)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glial cell differentiation
    (GO:0045687)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of immature t cell proliferation in thymus
    (GO:0033092)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of map kinase activity
    (GO:0043406)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of myosin light chain kinase activity
    (GO:0035505)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of prostaglandin biosynthetic process
    (GO:0031394)
  • Positive regulation of prostaglandin secretion
    (GO:0032308)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of stress-activated mapk cascade
    (GO:0032874)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Protein domain specific binding
    (GO:0019904)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of canonical nf-kappab signal transduction
    (GO:0043122)
  • Regulation of defense response to virus by host
    (GO:0050691)
  • Regulation of neurogenesis
    (GO:0050767)
  • Response to atp
    (GO:0033198)
  • Response to carbohydrate
    (GO:0009743)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Sequestering of triglyceride
    (GO:0030730)
  • Social behavior
    (GO:0035176)
  • Vascular endothelial growth factor production
    (GO:0010573)

Other Information

Genular Protein ID: 1221979760

Symbol: IL1B_MOUSE

Name: Interleukin-1 beta

UniProtKB Accession Codes:

P10749 Q2M4J6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRINTS 4 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3491144

Title: Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta.

PubMed ID: 3491144

PubMed ID: 3492706

Title: The murine interleukin 1 beta gene: structure and evolution.

PubMed ID: 3492706

DOI: 10.1093/nar/14.24.9955

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2967326

Title: Characterization of murine IL-1 beta. Isolation, expression, and purification.

PubMed ID: 2967326

PubMed ID: 16407890

Title: Cryopyrin activates the inflammasome in response to toxins and ATP.

PubMed ID: 16407890

DOI: 10.1038/nature04515

PubMed ID: 17284521

Title: Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death.

PubMed ID: 17284521

DOI: 10.1242/jcs.03377

PubMed ID: 17641058

Title: Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages.

PubMed ID: 17641058

DOI: 10.4049/jimmunol.179.3.1913

PubMed ID: 1807351

Title: The structure of murine interleukin-1 beta at 2.8-A resolution.

PubMed ID: 1807351

DOI: 10.1016/1047-8477(91)90021-n

Sequence Information:

  • Length: 269
  • Mass: 30931
  • Checksum: 734FA17B02ED87EE
  • Sequence:
    • MATVPELNCE MPPFDSDEND LFFEVDGPQK MKGCFQTFDL GCPDESIQLQ ISQQHINKSF 
RQAVSLIVAV EKLWQLPVSF PWTFQDEDMS TFFSFIFEEE PILCDSWDDD DNLLVCDVPI 
RQLHYRLRDE QQKSLVLSDP YELKALHLNG QNINQQVIFS MSFVQGEPSN DKIPVALGLK 
GKNLYLSCVM KDGTPTLQLE SVDPKQYPKK KMEKRFVFNK IEVKSKVEFE SAEFPNWYIS 
TSQAEHKPVF LGNNSGQDII DFTMESVSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.