Genular: Defining Cellular Identity and Function

Details for: Irak1

Gene ID: 16179

Symbol: Irak1

Ensembl ID: ENSMUSG00000031392

Description: interleukin-1 receptor-associated kinase 1

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irak1 recruits ikk complex
(R-MMU-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-MMU-975144)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-MMU-450321)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nf-kb is activated and signals survival
(R-MMU-209560)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Atp binding
(GO:0005524)
Canonical nf-kappab signal transduction
(GO:0007249)
Cellular response to heat
(GO:0034605)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Heat shock protein binding
(GO:0031072)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Interleukin-1 receptor binding
(GO:0005149)
Interleukin-1-mediated signaling pathway
(GO:0070498)
Interleukin-33-mediated signaling pathway
(GO:0038172)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Kinase activity
(GO:0016301)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Negative regulation of cholesterol efflux
(GO:0090370)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of leukocyte adhesion to vascular endothelial cell
(GO:1904996)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of type i interferon production
(GO:0032481)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cytokine-mediated signaling pathway
(GO:0001959)
Response to interleukin-1
(GO:0070555)
Response to lipopolysaccharide
(GO:0032496)
Response to peptidoglycan
(GO:0032494)
Signal transduction
(GO:0007165)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll signaling pathway
(GO:0008063)
Transferase activity
(GO:0016740)
Type i interferon-mediated signaling pathway
(GO:0060337)

Other Information

Proteins

Genular Protein ID: 1650196142

Symbol: IRAK1_MOUSE

Name: Interleukin-1 receptor-associated kinase 1

UniProtKB Accession Codes:

Q62406 B1AUW4 Q6Y3Z5 Q6Y3Z6

Database IDs:

Citations:

PubMed ID: 10723722

Title: Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

PubMed ID: 10723722

DOI: 10.1007/s003350010035

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8663605

Title: Developmental and tissue-specific expression of mouse pelle-like protein kinase.

PubMed ID: 8663605

DOI: 10.1074/jbc.271.30.17609

PubMed ID: 11096118

Title: SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity.

PubMed ID: 11096118

DOI: 10.1074/jbc.m010399200

PubMed ID: 12138165

Title: Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase.

PubMed ID: 12138165

DOI: 10.1074/jbc.m205160200

PubMed ID: 12370331

Title: Mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling.

PubMed ID: 12370331

DOI: 10.4049/jimmunol.169.8.4075

PubMed ID: 15767370

Title: Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.

PubMed ID: 15767370

DOI: 10.1084/jem.20042372

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 21435586

Title: Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

PubMed ID: 21435586

DOI: 10.1016/j.immuni.2011.03.010

PubMed ID: 22037600

Title: The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.

PubMed ID: 22037600

DOI: 10.1038/ni.2137

Sequence Information:

Length: 710
Mass: 77269
Checksum: 8A501F002CD3EBD2
Sequence:

MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPVVP PSTAAPRPSS 
ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLPVSLGPP LPSSAPSSTK 
SSPESPVSGL QRAHPSPFCW PFCEISQGTC NFSEELRIGE GGFGCVYRAV MRNTTYAVKR 
LKEEADLEWT MVKQSFLTEV EQLSRFRHPN IVDFAGYCAE SGLYCLVYGF LPNGSLEDQL 
HLQTQACSPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLMPKLGDFG 
LARFSRFAGA KASQSSTVAR TSTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVILETLAG 
QRAVRTQGAK TKYLKDLIED EAEEAGVTLK STQPTLWVGV ATDAWAAPIA AQIYKKHLDS 
RPGPCPPQLG LALAQLACCC MHRRAKKRPP MTQVYKRLEG LQAGPPWELE VAGHGSPSPQ 
ENSYMSTTGS AQSGDEPWQP LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH 
LTPGSHPSPA SFREASCTQG GTTRESSVRS SPGFQPTTME GSPTGSSSLL SSEPPQIIIN 
PARQKMVQKL ALYEEGVLDS LQLLSSGFFP GLDLEPEKSQ GPEESDEFQS

Genular Protein ID: 1624664066

Symbol: Q8BR10_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BR10

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 711
Mass: 77398
Checksum: 29949D41D04CB5BF
Sequence:

MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPVVP PSTAAPRPSS 
ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLPVSLGPP LPSSAPSSTK 
QSSPESPVSG LQRAHPSPFC WPFCEISQGT CNFSEELRIG EGGFGCVYRA VMRNTTYAVK 
RLKEEADLEW TMVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGLYCLVYG FLPNGSLEDQ 
LHLQTQACSP LSWPQRLDIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD ERLMPKLGDF 
GLARFSRFAG AKASQSSTVA RTSTVRGTLA YLPEEYIKTG RLAVDTDTFS FGVVILETLA 
GQRAVRTQGA KTKYLKDLIE DEAEEAGVTL KSTQPTLWVG VATDAWAAPI AAQIYKKHLD 
SRPGPCPPQL GLALAQLACC CMHRRAKKRP PMTQVYKRLE GLQAGPPWEL EVAGHGSPSP 
QENSYMSTTG SAQSGDEPWQ PLVVTTRAPA QAAQQLQRSP NQPVESDESV PGLSATLHSW 
HLTPGSHPSP ASFREASCTQ GGTTRESSVR SSPGFQPTTM EGSPTGSSSL LSSEPPQIII 
NPARQKMVQK LALYEEGVLD SLQLLSSGFF PGLDLEPEKS QGPEESDEFQ S

Genular Protein ID: 3365295700

Symbol: B1AUW6_MOUSE

Name: N/A

UniProtKB Accession Codes:

B1AUW6

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 750
Mass: 81885
Checksum: 53785E64444739F4
Sequence:

MAGGPGPGEP VVPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE 
RSEQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPVVP PSTAAPRPSS 
ISAGSEAGDW SPRKLQSSAS TFLSPAFPGS QTHSESELLQ VPLPVSLGPP LPSSAPSSTK 
QSSPESPVSG LQRAHPSPFC WPFCEISQGT CNFSEELRIG EGGFGCVYRA VMRNTTYAVK 
RLKEEADLEW TMVKQSFLTE VEQLSRFRHP NIVDFAGYCA ESGLYCLVYG FLPNGSLEDQ 
LHLQTQACSP LSWPQRLDIL LGTARAIQFL HQDSPSLIHG DIKSSNVLLD ERLMPKLGDF 
GLARFSRFAG AKASQSSTVA RTSTVRGTLA YLPEEYIKTG RLAVDTDTFS FGVVILETLA 
GQRAVRTQGA KTKYLKDLIE DEAEEAGVTL KSTQPTLWVG VATDAWAAPI AAQIYKKHLD 
SRPGPCPPQL GLALAQLACC CMHRRAKKRP PMTQRQNSQH SLLALWLYLG RCSVELSGKG 
LLLCWMSLRS QEQVYKRLEG LQAGPPWELE VAGHGSPSPQ ENSYMSTTGS AQSGDEPWQP 
LVVTTRAPAQ AAQQLQRSPN QPVESDESVP GLSATLHSWH LTPGSHPSPA SFREASCTQG 
GTTRESSVRS SPGFQPTTME GSPTGSSSLL SSEPPQIIIN PARQKMVQKL ALYEEGVLDS 
LQLLSSGFFP GLDLEPEKSQ GPEESDEFQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Irak1

Associated with

Other Information

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions. PubMed ID: 10723722

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Developmental and tissue-specific expression of mouse pelle-like protein kinase. PubMed ID: 8663605

SIMPL is a tumor necrosis factor-specific regulator of nuclear factor-kappaB activity. PubMed ID: 11096118

Identification of threonine 66 as a functionally critical residue of the interleukin-1 receptor-associated kinase. PubMed ID: 12138165

Mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling. PubMed ID: 12370331

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. PubMed ID: 15767370

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. PubMed ID: 21435586

The IkappaB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1. PubMed ID: 22037600

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 10723722

PubMed ID: 19468303

PubMed ID: 8663605

PubMed ID: 11096118

PubMed ID: 12138165

PubMed ID: 12370331

PubMed ID: 15767370

PubMed ID: 16951688

PubMed ID: 21435586

PubMed ID: 22037600

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 19468303