Genular: Defining Cellular Identity and Function

Details for: Il2

Gene ID: 16183

Symbol: Il2

Ensembl ID: ENSMUSG00000027720

Description: interleukin 2

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-2 signaling
(R-MMU-9020558)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin receptor shc signaling
(R-MMU-912526)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Raf/map kinase cascade
(R-MMU-5673001)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Activated t cell proliferation
(GO:0050798)
Adaptive immune response
(GO:0002250)
Carbohydrate binding
(GO:0030246)
Cellular response to biotic stimulus
(GO:0071216)
Cytokine activity
(GO:0005125)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Gene expression
(GO:0010467)
Glycosphingolipid binding
(GO:0043208)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth factor activity
(GO:0008083)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Interleukin-2 receptor binding
(GO:0005134)
Interleukin-2-mediated signaling pathway
(GO:0038110)
Kappa-type opioid receptor binding
(GO:0031851)
Leukocyte activation involved in immune response
(GO:0002366)
Lymphocyte proliferation
(GO:0046651)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of lymphocyte proliferation
(GO:0050672)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of t-helper 17 cell differentiation
(GO:2000320)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of plasma cell differentiation
(GO:1900100)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of regulatory t cell differentiation
(GO:0045591)
Positive regulation of t cell differentiation
(GO:0045582)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein kinase c-activating g protein-coupled receptor signaling pathway
(GO:0007205)
Regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000561)
Regulation of t cell homeostatic proliferation
(GO:0046013)
Response to ethanol
(GO:0045471)
T cell proliferation
(GO:0042098)
Transcription by rna polymerase ii
(GO:0006366)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Interleukin-2

Genular Protein ID: 2591003300

Symbol: IL2_MOUSE

Name: Interleukin-2

UniProtKB Accession Codes:

P04351 P97945 Q791T3

Database IDs:

Citations:

PubMed ID: 6240025

Title: Organization and structure of the mouse interleukin-2 gene.

PubMed ID: 6240025

DOI: 10.1093/nar/12.24.9323

PubMed ID: 2578624

Title: Unique structure of murine interleukin-2 as deduced from cloned cDNAs.

PubMed ID: 2578624

DOI: 10.1038/313402a0

PubMed ID: 3918306

Title: Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells.

PubMed ID: 3918306

DOI: 10.1073/pnas.82.1.68

PubMed ID: 3003564

Title: Cloning and structure of a mouse interleukin-2 chromosomal gene.

PubMed ID: 3003564

DOI: 10.1007/bf00417597

PubMed ID: 10779485

Title: Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping.

PubMed ID: 10779485

DOI: 10.1101/gr.10.4.446

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1420317

Title: A new cDNA sequence for the murine interleukin-2 gene.

PubMed ID: 1420317

DOI: 10.1016/0167-4781(92)90174-x

PubMed ID: 8319981

Title: Existence of at least five interleukin-2 molecules in different mouse strains.

PubMed ID: 8319981

DOI: 10.1007/bf00188809

PubMed ID: 9814585

Title: Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice.

PubMed ID: 9814585

DOI: 10.1155/1998/19567

PubMed ID: 11526406

Title: Inducible IL-2 production by dendritic cells revealed by global gene expression analysis.

PubMed ID: 11526406

DOI: 10.1038/ni0901-882

PubMed ID: 14614860

Title: Stat5 activation plays a critical role in Th2 differentiation.

PubMed ID: 14614860

DOI: 10.1016/s1074-7613(03)00292-9

PubMed ID: 27018889

Title: Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling.

PubMed ID: 27018889

DOI: 10.1038/nchembio.2056

PubMed ID: 8262055

Title: Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor.

PubMed ID: 8262055

DOI: 10.1002/j.1460-2075.1993.tb06206.x

PubMed ID: 25992858

Title: Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

PubMed ID: 25992858

DOI: 10.1016/j.immuni.2015.04.015

Sequence Information:

Length: 169
Mass: 19400
Checksum: B3B17644F6EF83CA
Sequence:

MYSMQLASCV TLTLVLLVNS APTSSSTSSS TAEAQQQQQQ QQQQQQHLEQ LLMDLQELLS 
RMENYRNLKL PRMLTFKFYL PKQATELKDL QCLEDELGPL RHVLDLTQSK SFQLEDAENF 
ISNIRVTVVK LKGSDNTFEC QFDDESATVV DFLRRWIAFC QSIISTSPQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il2

Associated with

Other Information

Organization and structure of the mouse interleukin-2 gene. PubMed ID: 6240025

Unique structure of murine interleukin-2 as deduced from cloned cDNAs. PubMed ID: 2578624

Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. PubMed ID: 3918306

Cloning and structure of a mouse interleukin-2 chromosomal gene. PubMed ID: 3003564

Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping. PubMed ID: 10779485

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A new cDNA sequence for the murine interleukin-2 gene. PubMed ID: 1420317

Existence of at least five interleukin-2 molecules in different mouse strains. PubMed ID: 8319981

Thymic stromal-cell abnormalities and dysregulated T-cell development in IL-2-deficient mice. PubMed ID: 9814585

Inducible IL-2 production by dendritic cells revealed by global gene expression analysis. PubMed ID: 11526406

Stat5 activation plays a critical role in Th2 differentiation. PubMed ID: 14614860

Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. PubMed ID: 27018889

Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. PubMed ID: 8262055

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. PubMed ID: 25992858