Genular: Defining Cellular Identity and Function

Details for: Il3

Gene ID: 16187

Symbol: Il3

Ensembl ID: ENSMUSG00000018914

Description: interleukin 3

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin receptor shc signaling
(R-MMU-912526)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Raf/map kinase cascade
(R-MMU-5673001)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Activation of janus kinase activity
(GO:0042976)
B cell apoptotic process
(GO:0001783)
B cell proliferation
(GO:0042100)
Cell population proliferation
(GO:0008283)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Embryonic hemopoiesis
(GO:0035162)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Growth factor activity
(GO:0008083)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Hemopoiesis
(GO:0030097)
Immune response
(GO:0006955)
Interleukin-3 receptor binding
(GO:0005135)
Interleukin-3-mediated signaling pathway
(GO:0038156)
Jnk cascade
(GO:0007254)
Mast cell apoptotic process
(GO:0033024)
Mast cell proliferation
(GO:0070662)
Monocyte differentiation
(GO:0030224)
Myeloid cell apoptotic process
(GO:0033028)
Myeloid leukocyte differentiation
(GO:0002573)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of b cell apoptotic process
(GO:0002903)
Negative regulation of mast cell apoptotic process
(GO:0033026)
Negative regulation of myeloid cell apoptotic process
(GO:0033033)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of hematopoietic progenitor cell differentiation
(GO:1901534)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of mast cell proliferation
(GO:0070668)
Positive regulation of myeloid leukocyte differentiation
(GO:0002763)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein phosphorylation
(GO:0006468)
Regulation of cell growth
(GO:0001558)
Regulation of gene expression
(GO:0010468)
Regulation of glycolytic process
(GO:0006110)
Regulation of protein dephosphorylation
(GO:0035304)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
T cell proliferation
(GO:0042098)

Other Information

Proteins

Interleukin-3

Genular Protein ID: 1432474285

Symbol: IL3_MOUSE

Name: Interleukin-3

UniProtKB Accession Codes:

P01586

Database IDs:

Citations:

PubMed ID: 6420702

Title: Molecular cloning of cDNA for murine interleukin-3.

PubMed ID: 6420702

DOI: 10.1038/307233a0

PubMed ID: 6322187

Title: Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.

PubMed ID: 6322187

DOI: 10.1073/pnas.81.4.1070

PubMed ID: 3918308

Title: Structure of the chromosomal gene for murine interleukin 3.

PubMed ID: 3918308

DOI: 10.1073/pnas.82.2.316

PubMed ID: 3926497

Title: Cloning and nucleotide sequence of the murine interleukin-3 gene.

PubMed ID: 3926497

DOI: 10.1111/j.1432-1033.1985.tb09020.x

PubMed ID: 3935516

Title: Isolation and characterization of a genomic DDD mouse interleukin-3 gene.

PubMed ID: 3935516

DOI: 10.1016/0378-1119(85)90114-3

PubMed ID: 1445902

Title: Determination of the glycosylation patterns, disulfide linkages, and protein heterogeneities of baculovirus-expressed mouse interleukin-3 by mass spectrometry.

PubMed ID: 1445902

DOI: 10.1021/bi00161a053

PubMed ID: 9446636

Title: Involvement of interleukin-3 in delayed-type hypersensitivity.

PubMed ID: 9446636

PubMed ID: 8378315

Title: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.

PubMed ID: 8378315

DOI: 10.1073/pnas.90.18.8429

PubMed ID: 10376805

Title: Role of STAT5 in interferon-alpha signal transduction in Ba/F3 cells.

PubMed ID: 10376805

DOI: 10.1016/s0898-6568(98)00049-7

PubMed ID: 31990690

Title: The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and innate immunity.

PubMed ID: 31990690

DOI: 10.1172/jci.insight.133652

PubMed ID: 21329364

Title: Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution.

PubMed ID: 21329364

DOI: 10.1021/bi101810f

Sequence Information:

Length: 166
Mass: 18540
Checksum: F38EE7A9E361CAA2
Sequence:

MVLASSTTSI HTMLLLLLML FHLGLQASIS GRDTHRLTRT LNCSSIVKEI IGKLPEPELK 
TDDEGPSLRN KSFRRVNLSK FVESQGEVDP EDRYVIKSNL QKLNCCLPTS ANDSALPGVF 
IRDLDDFRKK LRFYMVHLND LETVLTSRPP QPASGSVSPN RGTVEC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il3

Associated with

Other Information

Molecular cloning of cDNA for murine interleukin-3. PubMed ID: 6420702

Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. PubMed ID: 6322187

Structure of the chromosomal gene for murine interleukin 3. PubMed ID: 3918308

Cloning and nucleotide sequence of the murine interleukin-3 gene. PubMed ID: 3926497

Isolation and characterization of a genomic DDD mouse interleukin-3 gene. PubMed ID: 3935516

Determination of the glycosylation patterns, disulfide linkages, and protein heterogeneities of baculovirus-expressed mouse interleukin-3 by mass spectrometry. PubMed ID: 1445902

Involvement of interleukin-3 in delayed-type hypersensitivity. PubMed ID: 9446636

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. PubMed ID: 8378315

Role of STAT5 in interferon-alpha signal transduction in Ba/F3 cells. PubMed ID: 10376805

The RNFT2/IL-3Ralpha axis regulates IL-3 signaling and innate immunity. PubMed ID: 31990690

Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution. PubMed ID: 21329364