Details for: Il4

Gene ID: 16189

Symbol: Il4

Ensembl ID: ENSMUSG00000000869

Description: interleukin 4

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-4 and interleukin-13 signaling
    (R-MMU-6785807)
  • Signaling by interleukins
    (R-MMU-449147)
  • Activated t cell proliferation
    (GO:0050798)
  • Activation of janus kinase activity
    (GO:0042976)
  • Autophagy
    (GO:0006914)
  • B cell activation
    (GO:0042113)
  • B cell costimulation
    (GO:0031296)
  • B cell proliferation
    (GO:0042100)
  • Cholesterol metabolic process
    (GO:0008203)
  • Cytokine activity
    (GO:0005125)
  • Cytokine receptor binding
    (GO:0005126)
  • Defense response to protozoan
    (GO:0042832)
  • Dendritic cell differentiation
    (GO:0097028)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Extrinsic apoptotic signaling pathway
    (GO:0097191)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Growth factor activity
    (GO:0008083)
  • Immune response
    (GO:0006955)
  • Innate immune response in mucosa
    (GO:0002227)
  • Interleukin-4 receptor binding
    (GO:0005136)
  • Interleukin-4-mediated signaling pathway
    (GO:0035771)
  • Isotype switching to ige isotypes
    (GO:0048289)
  • Isotype switching to igg isotypes
    (GO:0048291)
  • Macrophage activation
    (GO:0042116)
  • Mhc class ii biosynthetic process
    (GO:0045342)
  • Microglial cell activation
    (GO:0001774)
  • Myeloid dendritic cell differentiation
    (GO:0043011)
  • Negative regulation of acute inflammatory response
    (GO:0002674)
  • Negative regulation of cellular response to transforming growth factor beta stimulus
    (GO:1903845)
  • Negative regulation of chronic inflammatory response
    (GO:0002677)
  • Negative regulation of complement-dependent cytotoxicity
    (GO:1903660)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of epithelial cell migration
    (GO:0010633)
  • Negative regulation of extrinsic apoptotic signaling pathway
    (GO:2001237)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of macrophage activation
    (GO:0043031)
  • Negative regulation of nitric oxide biosynthetic process
    (GO:0045019)
  • Negative regulation of osteoclast differentiation
    (GO:0045671)
  • Negative regulation of t-helper 17 cell differentiation
    (GO:2000320)
  • Negative regulation of t cell activation
    (GO:0050868)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of white fat cell proliferation
    (GO:0070351)
  • Neuroinflammatory response
    (GO:0150076)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of amyloid-beta clearance
    (GO:1900223)
  • Positive regulation of atp biosynthetic process
    (GO:2001171)
  • Positive regulation of b cell activation
    (GO:0050871)
  • Positive regulation of b cell proliferation
    (GO:0030890)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cellular respiration
    (GO:1901857)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of eosinophil chemotaxis
    (GO:2000424)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of isotype switching to ige isotypes
    (GO:0048295)
  • Positive regulation of isotype switching to igg isotypes
    (GO:0048304)
  • Positive regulation of macroautophagy
    (GO:0016239)
  • Positive regulation of mast cell degranulation
    (GO:0043306)
  • Positive regulation of mhc class ii biosynthetic process
    (GO:0045348)
  • Positive regulation of mononuclear cell migration
    (GO:0071677)
  • Positive regulation of myoblast fusion
    (GO:1901741)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of reactive oxygen species biosynthetic process
    (GO:1903428)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Positive regulation of t-helper 2 cell cytokine production
    (GO:2000553)
  • Positive regulation of t cell differentiation
    (GO:0045582)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Regulation of immune response
    (GO:0050776)
  • Regulation of proton transport
    (GO:0010155)
  • T-helper 1 cell lineage commitment
    (GO:0002296)
  • T-helper 2 cell differentiation
    (GO:0045064)
  • T cell activation
    (GO:0042110)
  • T cell proliferation
    (GO:0042098)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Tyrosine phosphorylation of stat protein
    (GO:0007260)

Other Information

Genular Protein ID: 1566141030

Symbol: IL4_MOUSE

Name: Interleukin-4

UniProtKB Accession Codes:

P07750

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 82 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 3005865

Title: Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter.

PubMed ID: 3005865

DOI: 10.1038/319640a0

PubMed ID: 3029676

Title: Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities.

PubMed ID: 3029676

DOI: 10.1093/nar/15.1.333

PubMed ID: 3083412

Title: Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast-cell-stimulating activities.

PubMed ID: 3083412

DOI: 10.1073/pnas.83.7.2061

PubMed ID: 3498301

Title: IgG1 induction factor: a single molecular entity with multiple biological functions.

PubMed ID: 3498301

DOI: 10.1007/978-1-4684-5323-2_22

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1993171

Title: Disulfide assignments in recombinant mouse and human interleukin 4.

PubMed ID: 1993171

DOI: 10.1021/bi00220a011

PubMed ID: 8624821

Title: Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

PubMed ID: 8624821

DOI: 10.1016/s1074-7613(00)80439-2

PubMed ID: 25847241

Title: Th2 Cytokines Augment IL-31/IL-31RA Interactions via STAT6-dependent IL-31RA Expression.

PubMed ID: 25847241

DOI: 10.1074/jbc.m114.622126

PubMed ID: 26416964

Title: RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

PubMed ID: 26416964

DOI: 10.1083/jcb.201501059

PubMed ID: 25772794

Title: IL-4 Knock Out Mice Display Anxiety-Like Behavior.

PubMed ID: 25772794

DOI: 10.1007/s10519-015-9714-x

PubMed ID: 28202615

Title: IL-13-Mediated Regulation of Learning and Memory.

PubMed ID: 28202615

DOI: 10.4049/jimmunol.1601546

Sequence Information:

  • Length: 140
  • Mass: 15834
  • Checksum: E43CE16195DE051F
  • Sequence:
    • MGLNPQLVVI LLFFLECTRS HIHGCDKNHL REIIGILNEV TGEGTPCTEM DVPNVLTATK 
NTTESELVCR ASKVLRIFYL KHGKTPCLKK NSSVLMELQR LFRAFRCLDS SISCTMNESK 
STSLKDFLES LKSIMQMDYS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.