Genular: Defining Cellular Identity and Function

Details for: Il4ra

Gene ID: 16190

Symbol: Il4ra

Ensembl ID: ENSMUSG00000030748

Description: interleukin 4 receptor, alpha

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-4 and interleukin-13 signaling
(R-MMU-6785807)
Signaling by interleukins
(R-MMU-449147)
Centriolar satellite
(GO:0034451)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor activity
(GO:0004896)
Defense response to protozoan
(GO:0042832)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune system process
(GO:0002376)
Immunoglobulin mediated immune response
(GO:0016064)
Interleukin-4 receptor activity
(GO:0004913)
Interleukin-4-mediated signaling pathway
(GO:0035771)
Membrane
(GO:0016020)
Negative regulation of t-helper 1 cell differentiation
(GO:0045626)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of mast cell degranulation
(GO:0043306)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Production of molecular mediator involved in inflammatory response
(GO:0002532)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of cell population proliferation
(GO:0042127)
T-helper 1 cell differentiation
(GO:0045063)
T-helper 2 cell differentiation
(GO:0045064)

Other Information

Proteins

Interleukin-4 receptor subunit alpha

Genular Protein ID: 4081682288

Symbol: IL4RA_MOUSE

Name: Interleukin-4 receptor subunit alpha

UniProtKB Accession Codes:

P16382 O54690 Q60583 Q8CBW5

Database IDs:

Citations:

PubMed ID: 2805066

Title: The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms.

PubMed ID: 2805066

DOI: 10.1016/0092-8674(89)90295-x

PubMed ID: 2405398

Title: Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding.

PubMed ID: 2405398

DOI: 10.1073/pnas.87.3.857

PubMed ID: 1534014

Title: The murine interleukin-4 receptor gene: genomic structure, expression and potential for alternative splicing.

PubMed ID: 1534014

DOI: 10.3109/08977199209011014

PubMed ID: 9348299

Title: Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes.

PubMed ID: 9348299

DOI: 10.1084/jem.186.9.1419

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12242343

Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.

PubMed ID: 12242343

DOI: 10.1073/pnas.202477099

PubMed ID: 8390454

Title: Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2.

PubMed ID: 8390454

DOI: 10.1016/s0021-9258(19)38624-7

PubMed ID: 8757301

Title: Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor.

PubMed ID: 8757301

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 26124135

Title: CD300f associates with IL-4 receptor alpha and amplifies IL-4-induced immune cell responses.

PubMed ID: 26124135

DOI: 10.1073/pnas.1507625112

Sequence Information:

Length: 810
Mass: 87627
Checksum: 536B9E01E938FF6D
Sequence:

MGRLCTKFLT SVGCLILLLV TGSGSIKVLG EPTCFSDYIR TSTCEWFLDS AVDCSSQLCL 
HYRLMFFEFS ENLTCIPRNS ASTVCVCHME MNRPVQSDRY QMELWAEHRQ LWQGSFSPSG 
NVKPLAPDNL TLHTNVSDEW LLTWNNLYPS NNLLYKDLIS MVNISREDNP AEFIVYNVTY 
KEPRLSFPIN ILMSGVYYTA RVRVRSQILT GTWSEWSPSI TWYNHFQLPL IQRLPLGVTI 
SCLCIPLFCL FCYFSITKIK KIWWDQIPTP ARSPLVAIII QDAQVPLWDK QTRSQESTKY 
PHWKTCLDKL LPCLLKHRVK KKTDFPKAAP TKSLQSPGKA GWCPMEVSRT VLWPENVSVS 
VVRCMELFEA PVQNVEEEED EIVKEDLSMS PENSGGCGFQ ESQADIMARL TENLFSDLLE 
AENGGLGQSA LAESCSPLPS GSGQASVSWA CLPMGPSEEA TCQVTEQPSH PGPLSGSPAQ 
SAPTLACTQV PLVLADNPAY RSFSDCCSPA PNPGELAPEQ QQADHLEEEE PPSPADPHSS 
GPPMQPVESW EQILHMSVLQ HGAAAGSTPA PAGGYQEFVQ AVKQGAAQDP GVPGVRPSGD 
PGYKAFSSLL SSNGIRGDTA AAGTDDGHGG YKPFQNPVPN QSPSSVPLFT FGLDTELSPS 
PLNSDPPKSP PECLGLELGL KGGDWVKAPP PADQVPKPFG DDLGFGIVYS SLTCHLCGHL 
KQHHSQEEGG QSPIVASPGC GCCYDDRSPS LGSLSGALES CPEGIPPEAN LMSAPKTPSN 
LSGEGKGPGH SPVPSQTTEV PVGALGIAVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il4ra

Associated with

Other Information

The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. PubMed ID: 2805066

Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding. PubMed ID: 2405398

The murine interleukin-4 receptor gene: genomic structure, expression and potential for alternative splicing. PubMed ID: 1534014

Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes. PubMed ID: 9348299

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. PubMed ID: 12242343

Interleukin-4 (IL-4) induces protein tyrosine phosphorylation of the IL-4 receptor and association of phosphatidylinositol 3-kinase to the IL-4 receptor in a mouse T cell line, HT2. PubMed ID: 8390454

Two distinct stimulus-dependent pathways lead to production of soluble murine interleukin-4 receptor. PubMed ID: 8757301

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

CD300f associates with IL-4 receptor alpha and amplifies IL-4-induced immune cell responses. PubMed ID: 26124135