Details for: Il6

Gene ID: 16193

Symbol: Il6

Ensembl ID: ENSMUSG00000025746

Description: interleukin 6

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Interleukin-6 family signaling
    (R-MMU-6783589)
  • Interleukin-6 signaling
    (R-MMU-1059683)
  • Mapk1 (erk2) activation
    (R-MMU-112411)
  • Mapk1/mapk3 signaling
    (R-MMU-5684996)
  • Mapk3 (erk1) activation
    (R-MMU-110056)
  • Mapk family signaling cascades
    (R-MMU-5683057)
  • Metabolism of proteins
    (R-MMU-392499)
  • Post-translational protein modification
    (R-MMU-597592)
  • Post-translational protein phosphorylation
    (R-MMU-8957275)
  • Raf-independent mapk1/3 activation
    (R-MMU-112409)
  • Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
    (R-MMU-381426)
  • Signaling by interleukins
    (R-MMU-449147)
  • Signal transduction
    (R-MMU-162582)
  • Acute-phase response
    (GO:0006953)
  • Cell redox homeostasis
    (GO:0045454)
  • Cellular response to hepatocyte growth factor stimulus
    (GO:0035729)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytokine activity
    (GO:0005125)
  • Defense response to protozoan
    (GO:0042832)
  • Endocrine pancreas development
    (GO:0031018)
  • Gene expression
    (GO:0010467)
  • Germinal center b cell differentiation
    (GO:0002314)
  • Glucose homeostasis
    (GO:0042593)
  • Growth factor activity
    (GO:0008083)
  • Hepatic immune response
    (GO:0002384)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Interleukin-6 receptor binding
    (GO:0005138)
  • Muscle cell cellular homeostasis
    (GO:0046716)
  • Myeloid cell homeostasis
    (GO:0002262)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bone resorption
    (GO:0045779)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of chemokine production
    (GO:0032682)
  • Negative regulation of collagen biosynthetic process
    (GO:0032966)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of hormone secretion
    (GO:0046888)
  • Negative regulation of membrane potential
    (GO:0045837)
  • Negative regulation of muscle organ development
    (GO:0048635)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Neuron projection development
    (GO:0031175)
  • Neutrophil apoptotic process
    (GO:0001781)
  • Positive regulation of acute inflammatory response
    (GO:0002675)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna replication
    (GO:0045740)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of gliogenesis
    (GO:0014015)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-17 production
    (GO:0032740)
  • Positive regulation of interleukin-21 production
    (GO:0032745)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of neuron projection development
    (GO:0010976)
  • Positive regulation of nitric oxide biosynthetic process
    (GO:0045429)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of protein import into nucleus
    (GO:0042307)
  • Positive regulation of receptor signaling pathway via jak-stat
    (GO:0046427)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of t-helper 2 cell differentiation
    (GO:0045630)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of translation
    (GO:0045727)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Protein binding
    (GO:0005515)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of cell shape
    (GO:0008360)
  • Regulation of circadian sleep/wake cycle, non-rem sleep
    (GO:0045188)
  • Regulation of vascular endothelial growth factor production
    (GO:0010574)
  • Response to activity
    (GO:0014823)
  • Response to wounding
    (GO:0009611)
  • Signaling receptor binding
    (GO:0005102)
  • T-helper 2 cell differentiation
    (GO:0045064)
  • T cell activation
    (GO:0042110)
  • Vascular endothelial growth factor production
    (GO:0010573)

Other Information

Genular Protein ID: 624390072

Symbol: IL6_MOUSE

Name: B-cell hybridoma growth factor

UniProtKB Accession Codes:

P08505 Q3UCQ0 Q8BN26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 2965020

Title: cDNA cloning of murine interleukin-HP1: homology with human interleukin 6.

PubMed ID: 2965020

DOI: 10.1002/eji.1830180202

PubMed ID: 3263439

Title: Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human.

PubMed ID: 3263439

PubMed ID: 3262872

Title: Multiple biological activities are expressed by a mouse interleukin 6 cDNA clone isolated from bone marrow stromal cells.

PubMed ID: 3262872

DOI: 10.1073/pnas.85.19.7099

PubMed ID: 2243807

Title: Cloning and sequence analysis of the cDNA for murine interleukin-6.

PubMed ID: 2243807

DOI: 10.1093/nar/18.21.6455

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 2106569

Title: DNA rearrangement and constitutive expression of the interleukin 6 gene in a mouse plasmacytoma.

PubMed ID: 2106569

DOI: 10.1084/jem.171.3.965

PubMed ID: 2563387

Title: The murine Il-6 gene maps to the proximal region of chromosome 5.

PubMed ID: 2563387

PubMed ID: 2948184

Title: Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

PubMed ID: 2948184

DOI: 10.1073/pnas.83.24.9679

PubMed ID: 3262059

Title: Murine hybridoma/plasmacytoma growth factor. Complete amino-acid sequence and relation to human interleukin-6.

PubMed ID: 3262059

DOI: 10.1111/j.1432-1033.1988.tb14267.x

PubMed ID: 2302197

Title: Internal amino acid sequencing of proteins by in situ cyanogen bromide cleavage in polyacrylamide gels.

PubMed ID: 2302197

DOI: 10.1016/0006-291x(90)91922-f

PubMed ID: 3264160

Title: Characterization of a recombinant murine interleukin-6: assignment of disulphide bonds.

PubMed ID: 3264160

DOI: 10.1016/s0006-291x(88)80056-1

PubMed ID: 8910279

Title: Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

PubMed ID: 8910279

DOI: 10.1126/science.274.5291.1379

PubMed ID: 11113088

Title: Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.

PubMed ID: 11113088

DOI: 10.1053/gast.2000.20236

PubMed ID: 11786910

Title: Interleukin-6-deficient mice develop mature-onset obesity.

PubMed ID: 11786910

DOI: 10.1038/nm0102-75

PubMed ID: 15124018

Title: IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

PubMed ID: 15124018

DOI: 10.1172/jci20945

PubMed ID: 17075861

Title: Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system.

PubMed ID: 17075861

DOI: 10.1002/art.22175

PubMed ID: 16990136

Title: The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

PubMed ID: 16990136

DOI: 10.1016/j.cell.2006.07.035

PubMed ID: 22037645

Title: Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

PubMed ID: 22037645

DOI: 10.1038/nm.2513

PubMed ID: 23045607

Title: B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.

PubMed ID: 23045607

DOI: 10.1084/jem.20111504

PubMed ID: 28402851

Title: IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.

PubMed ID: 28402851

DOI: 10.1016/j.celrep.2017.03.043

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 27893700

Title: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

PubMed ID: 27893700

DOI: 10.1038/ni.3632

PubMed ID: 30995492

Title: Targeting Interleukin-6 Signaling in Clinic.

PubMed ID: 30995492

DOI: 10.1016/j.immuni.2019.03.026

Sequence Information:

  • Length: 211
  • Mass: 24384
  • Checksum: BBB47DDA9E86787A
  • Sequence:
    • MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW 
EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 
HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEVKDL HKIVLPTPIS NALLTDKLES 
QKEWLRTKTI QFILKSLEEF LKVTLRSTRQ T

Genular Protein ID: 650530097

Symbol: A0A0G2JGF4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JGF4

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneTree 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 165
  • Mass: 19020
  • Checksum: 918C945729940392
  • Sequence:
    • MKFLSARDFH PVAFLGLMLV TTTAFPTSQV RRGDFTEDTT PNRPVYTTSQ VGGLITHVLW 
EIVEMRKELC NGNSDCMNND DALAENNLKL PEIQRNDGCY QTGYNQEICL LKISSGLLEY 
HSYLEYMKNN LKDNKKDKAR VLQRDTETLI HIFNQEISWS HRRSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.