Genular: Defining Cellular Identity and Function

Details for: Il6ra

Gene ID: 16194

Symbol: Il6ra

Ensembl ID: ENSMUSG00000027947

Description: interleukin 6 receptor, alpha

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interleukin-6 family signaling
(R-MMU-6783589)
Interleukin-6 signaling
(R-MMU-1059683)
Mapk1 (erk2) activation
(R-MMU-112411)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk3 (erk1) activation
(R-MMU-110056)
Mapk family signaling cascades
(R-MMU-5683057)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Signaling by interleukins
(R-MMU-449147)
Signal transduction
(R-MMU-162582)
Apical plasma membrane
(GO:0016324)
Ciliary neurotrophic factor-mediated signaling pathway
(GO:0070120)
Ciliary neurotrophic factor binding
(GO:0070119)
Ciliary neurotrophic factor receptor activity
(GO:0004897)
Ciliary neurotrophic factor receptor complex
(GO:0070110)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine receptor activity
(GO:0004896)
Developmental growth
(GO:0048589)
Endocrine pancreas development
(GO:0031018)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Interleukin-6 binding
(GO:0019981)
Interleukin-6 receptor activity
(GO:0004915)
Interleukin-6 receptor binding
(GO:0005138)
Interleukin-6 receptor complex
(GO:0005896)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Interleukin-11 binding
(GO:0019970)
Interleukin-11 receptor activity
(GO:0004921)
Membrane
(GO:0016020)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Neuronal cell body membrane
(GO:0032809)
Plasma membrane
(GO:0005886)
Positive regulation of activation of janus kinase activity
(GO:0010536)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of glomerular mesangial cell proliferation
(GO:0072126)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of platelet aggregation
(GO:1901731)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein homodimerization activity
(GO:0042803)
Receptor complex
(GO:0043235)
Response to cytokine
(GO:0034097)
T-helper 17 cell lineage commitment
(GO:0072540)
Vascular endothelial growth factor production
(GO:0010573)

Other Information

Proteins

Genular Protein ID: 4100040414

Symbol: IL6RA_MOUSE

Name: IL-6R 1

UniProtKB Accession Codes:

P22272

Database IDs:

Citations:

PubMed ID: 2112585

Title: Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.

PubMed ID: 2112585

DOI: 10.1084/jem.171.6.2001

PubMed ID: 11113088

Title: Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration.

PubMed ID: 11113088

DOI: 10.1053/gast.2000.20236

PubMed ID: 28265003

Title: SorLA in Interleukin-6 Signaling and Turnover.

PubMed ID: 28265003

DOI: 10.1128/mcb.00641-16

PubMed ID: 26876177

Title: Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

PubMed ID: 26876177

DOI: 10.1016/j.celrep.2016.01.053

PubMed ID: 28402851

Title: IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.

PubMed ID: 28402851

DOI: 10.1016/j.celrep.2017.03.043

PubMed ID: 27893700

Title: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.

PubMed ID: 27893700

DOI: 10.1038/ni.3632

PubMed ID: 30995492

Title: Targeting Interleukin-6 Signaling in Clinic.

PubMed ID: 30995492

DOI: 10.1016/j.immuni.2019.03.026

Sequence Information:

Length: 460
Mass: 50455
Checksum: F85C5906D08525C4
Sequence:

MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK EAAGNVTIHW 
VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK 
NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG 
DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET 
WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 
SEWSPEVTGT PWIAEPRTTP AGILWNPTQV SVEDSANHED QYESSTEATS VLAPVQESSS 
MSLPTFLVAG GSLAFGLLLC VFIILRLKQK WKSEAEKESK TTSPPPPPYS LGPLKPTFLL 
VPLLTPHSSG SDNTVNHSCL GVRDAQSPYD NSNRDYLFPR

Genular Protein ID: 1458917231

Symbol: A0A0G2JGF1_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JGF1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 459
Mass: 50384
Checksum: 2262BDFB786C292A
Sequence:

MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGK EAAGNVTIHW 
VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK 
NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG 
DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET 
WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 
SEWSPEVTGT PWIEPRTTPA GILWNPTQVS VEDSANHEDQ YESSTEATSV LAPVQESSSM 
SLPTFLVAGG SLAFGLLLCV FIILRLKQKW KSEAEKESKT TSPPPPPYSL GPLKPTFLLV 
PLLTPHSSGS DNTVNHSCLG VRDAQSPYDN SNRDYLFPR

Genular Protein ID: 305254892

Symbol: Q3URV7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3URV7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 459
Mass: 50384
Checksum: 3575EE8FC6AB8477
Sequence:

MLTVGCTLLV ALLAAPAVAL VLGSCRALEV ANGTVTSLPG ATVTLICPGE EAAGNVTIHW 
VYSGSQNREW TTTGNTLVLR DVQLSDTGDY LCSLNDHLVG TVPLLVDVPP EEPKLSCFRK 
NPLVNAICEW RPSSTPSPTT KAVLFAKKIN TTNGKSDFQV PCQYSQQLKS FSCQVEILEG 
DKVYHIVSLC VANSVGSKSS HNEAFHSLKM VQPDPPANLV VSAIPGRPRW LKVSWQHPET 
WDPSYYLLQF QLRYRPVWSK EFTVLLLPVA QYQCVIHDAL RGVKHVVQVR GKEELDLGQW 
SEWSPEVTGT PWIEPRTTPA GILWNPTQVS VEDSANHEDQ YESSTEATSV LAPVQESSSM 
SLPTFLVAGG SLAFGLLLCV FIILRLKQKW KSEAEKESKT TSPPPPPYSL GPLKPTFLLV 
PLLTPHSSGS DNTVNHSCLG VRDAQSPYDN SNRDYLFPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Il6ra

Associated with

Other Information

Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. PubMed ID: 2112585

Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. PubMed ID: 11113088

SorLA in Interleukin-6 Signaling and Turnover. PubMed ID: 28265003

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling. PubMed ID: 26876177

IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling. PubMed ID: 28402851

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. PubMed ID: 27893700

Targeting Interleukin-6 Signaling in Clinic. PubMed ID: 30995492

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Database document:

PubMed ID: 2112585

PubMed ID: 11113088

PubMed ID: 28265003

PubMed ID: 26876177

PubMed ID: 28402851

PubMed ID: 27893700

PubMed ID: 30995492

PubMed ID: 19468303

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073