Details for: AP1B1

Gene ID: 162

Symbol: AP1B1

Ensembl ID: ENSG00000100280

Description: adaptor related protein complex 1 subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.32
    Marker Score: 2804
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.12
    Marker Score: 1055
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.93
    Marker Score: 789
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.87
    Marker Score: 1028
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.71
    Marker Score: 617
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.57
    Marker Score: 2863
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167223
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.4
    Marker Score: 14450
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11645
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.35
    Marker Score: 1993
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.35
    Marker Score: 2077
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.31
    Marker Score: 1494
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.29
    Marker Score: 314
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.22
    Marker Score: 11636
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.21
    Marker Score: 1113
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.21
    Marker Score: 1736
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73478
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.18
    Marker Score: 1177
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.17
    Marker Score: 43301
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 976.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.17
    Marker Score: 4589
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 362
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.12
    Marker Score: 2646
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.1
    Marker Score: 23532
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.09
    Marker Score: 2952
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.09
    Marker Score: 4420
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.08
    Marker Score: 437
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.08
    Marker Score: 1137.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.07
    Marker Score: 3174
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.07
    Marker Score: 1152
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16533
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.04
    Marker Score: 927
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.04
    Marker Score: 694
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251639
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.04
    Marker Score: 4004
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.03
    Marker Score: 1218
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.03
    Marker Score: 57683
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.03
    Marker Score: 2003
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.03
    Marker Score: 39008
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.03
    Marker Score: 9656
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.02
    Marker Score: 429
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.01
    Marker Score: 1349
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.01
    Marker Score: 1123
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71657
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47882
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.99
    Marker Score: 4749
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.99
    Marker Score: 2250
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.99
    Marker Score: 344
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.97
    Marker Score: 2378
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.96
    Marker Score: 650
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.96
    Marker Score: 558
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.96
    Marker Score: 11129
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.96
    Marker Score: 1055.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.94
    Marker Score: 295
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.94
    Marker Score: 468
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.93
    Marker Score: 12472
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.93
    Marker Score: 702
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.92
    Marker Score: 942
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.92
    Marker Score: 573
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.91
    Marker Score: 685.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.91
    Marker Score: 7872
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.91
    Marker Score: 7082.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.91
    Marker Score: 18013
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.9
    Marker Score: 1568
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.9
    Marker Score: 13420
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.89
    Marker Score: 227
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.89
    Marker Score: 219
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4977
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.87
    Marker Score: 838
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.87
    Marker Score: 457
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 420
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.86
    Marker Score: 2716
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.86
    Marker Score: 204
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1388
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.85
    Marker Score: 196
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.85
    Marker Score: 2116
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.82
    Marker Score: 3407
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.82
    Marker Score: 6296
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.82
    Marker Score: 1716
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.82
    Marker Score: 708
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.81
    Marker Score: 403
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.81
    Marker Score: 1012.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.81
    Marker Score: 550
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 613.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.8
    Marker Score: 179
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.8
    Marker Score: 334
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.8
    Marker Score: 1326
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.8
    Marker Score: 546
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.8
    Marker Score: 531
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.8
    Marker Score: 5093
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.8
    Marker Score: 562
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.79
    Marker Score: 546

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Other Information

**Key characteristics:** * AP1B1 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the AP1 family of adaptor proteins, which are involved in regulating cell signaling pathways. * AP1B1 is a key regulator of the adaptive immune response, as it is expressed in cells that are activated by antigens. * It interacts with various cell surface receptors, including CD28, CD40, and CD80. * AP1B1 is also involved in the regulation of apoptosis and differentiation. **Pathways and functions:** * AP1B1 is involved in the regulation of adaptive immune responses by interacting with cell surface receptors and signaling molecules. * It is essential for the activation of CD8+ T cells and the induction of an adaptive immune response. * It also plays a role in the regulation of dendritic cell function and the maturation of dendritic cells into antigen-presenting cells. * AP1B1 is also involved in the regulation of cell migration and adhesion. **Clinical significance:** * Mutations in the AP1B1 gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, psoriasis, and lupus. * AP1B1 is also a potential therapeutic target for cancer, as it is frequently overexpressed in cancer cells. **Additional points:** * AP1B1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a ubiquitin-dependent protein, which means that it is targeted for degradation by the proteasome when it is no longer needed. * AP1B1 is a versatile adaptor protein that can interact with a wide range of cell surface receptors.

Genular Protein ID: 4288349243

Symbol: AP1B1_HUMAN

Name: AP-1 complex subunit beta-1

UniProtKB Accession Codes:

Q10567 C9JRD1 F8WDL0 P78436 Q20WL3 Q86X54

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 27 EMDB 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 20 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7987321

Title: Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene.

PubMed ID: 7987321

DOI: 10.1093/hmg/3.8.1393

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8812422

Title: Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12.

PubMed ID: 8812422

DOI: 10.1006/geno.1996.0431

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31630791

Title: Homozygous loss-of-function mutations in AP1B1, encoding beta-1 subunit of adaptor-related protein complex 1, cause MEDNIK-like syndrome.

PubMed ID: 31630791

DOI: 10.1016/j.ajhg.2019.09.020

PubMed ID: 31630788

Title: Recessive mutations in AP1B1 cause ichthyosis, deafness, and photophobia.

PubMed ID: 31630788

DOI: 10.1016/j.ajhg.2019.09.021

Sequence Information:

  • Length: 949
  • Mass: 104607
  • Checksum: 0B010DD2F29B248E
  • Sequence:
    • MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT 
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE 
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA 
VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI 
CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY 
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK 
YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 
QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV 
VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS 
ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS VQMGAVDLLG 
GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS DLFDLTSGVG TLSGSYVAPK 
AVWLPAMKAK GLEISGTFTR QVGSISMDLQ LTNKALQVMT DFAIQFNRNS FGLAPAAPLQ 
VHAPLSPNQT VEISLPLSTV GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK 
MDRQMFLATW KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL 
KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.