Genular: Defining Cellular Identity and Function

Details for: Ilk

Gene ID: 16202

Symbol: Ilk

Ensembl ID: ENSMUSG00000030890

Description: integrin linked kinase

Associated with

Cell-cell communication
(R-MMU-1500931)
Cell-extracellular matrix interactions
(R-MMU-446353)
Cell junction organization
(R-MMU-446728)
Localization of the pinch-ilk-parvin complex to focal adhesions
(R-MMU-446343)
Anchoring junction
(GO:0070161)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Branching involved in ureteric bud morphogenesis
(GO:0001658)
Cell-cell junction
(GO:0005911)
Cell-matrix adhesion
(GO:0007160)
Cell morphogenesis
(GO:0000902)
Cell population proliferation
(GO:0008283)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Costamere
(GO:0043034)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendritic shaft
(GO:0043198)
Establishment or maintenance of epithelial cell apical/basal polarity
(GO:0045197)
Fibroblast migration
(GO:0010761)
Focal adhesion
(GO:0005925)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Kinase activity
(GO:0016301)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Myelin assembly
(GO:0032288)
Myelination in peripheral nervous system
(GO:0022011)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of neural precursor cell proliferation
(GO:2000178)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell migration
(GO:0014912)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Nerve development
(GO:0021675)
Neural precursor cell proliferation
(GO:0061351)
Neuronal cell body
(GO:0043025)
Neuron projection morphogenesis
(GO:0048812)
Nucleotide binding
(GO:0000166)
Outflow tract morphogenesis
(GO:0003151)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of axon extension
(GO:0045773)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of signal transduction
(GO:0009967)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell growth
(GO:0001558)
Schwann cell development
(GO:0014044)
Sh3 domain binding
(GO:0017124)
Stress fiber
(GO:0001725)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Supramolecular fiber organization
(GO:0097435)
Terminal bouton
(GO:0043195)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)

Other Information

Proteins

ILK_MOUSE

Genular Protein ID: 3866907541

Symbol: ILK_MOUSE

Name: N/A

UniProtKB Accession Codes:

O55222 Q78KK2

Database IDs:

Citations:

PubMed ID: 9366252

Title: Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase.

PubMed ID: 9366252

DOI: 10.1016/s0167-4889(97)00089-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16737959

Title: Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex.

PubMed ID: 16737959

DOI: 10.1074/jbc.m513111200

PubMed ID: 18325335

Title: Affixin activates Rac1 via betaPIX in C2C12 myoblast.

PubMed ID: 18325335

DOI: 10.1016/j.febslet.2008.01.064

PubMed ID: 18483218

Title: Kindlin-2 controls bidirectional signaling of integrins.

PubMed ID: 18483218

DOI: 10.1101/gad.469408

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 452
Mass: 51373
Checksum: F41960CF8EC503A7
Sequence:

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 
NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 
ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 
TLNKHSGIDF KQLNFLAKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 
RLRIFSHPNV LPVLGACQAP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 
MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 
LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 
VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ilk

Associated with

Other Information

Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. PubMed ID: 9366252

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Oligomerizing potential of a focal adhesion LIM protein Hic-5 organizing a nuclear-cytoplasmic shuttling complex. PubMed ID: 16737959

Affixin activates Rac1 via betaPIX in C2C12 myoblast. PubMed ID: 18325335

Kindlin-2 controls bidirectional signaling of integrins. PubMed ID: 18483218

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337