Genular: Defining Cellular Identity and Function

Details for: Impact

Gene ID: 16210

Symbol: Impact

Ensembl ID: ENSMUSG00000024423

Description: impact, RWD domain protein

Associated with

Actin binding
(GO:0003779)
Cell differentiation
(GO:0030154)
Cellular response to amino acid starvation
(GO:0034198)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gcn2-mediated signaling
(GO:0140469)
Intracellular signal transduction
(GO:0035556)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuron projection extension
(GO:1990138)
Positive regulation of neuron differentiation
(GO:0045666)
Protein binding
(GO:0005515)
Protein sequestering activity
(GO:0140311)
Regulation of cytoplasmic translational initiation in response to stress
(GO:1990611)
Regulation of translation
(GO:0006417)
Regulation of translational initiation
(GO:0006446)
Ribosome binding
(GO:0043022)

Other Information

Proteins

Protein IMPACT

Genular Protein ID: 1962568635

Symbol: IMPCT_MOUSE

Name: Protein IMPACT

UniProtKB Accession Codes:

O55091 Q3UUR6 Q9EQH0

Database IDs:

Citations:

PubMed ID: 9256468

Title: Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18.

PubMed ID: 9256468

DOI: 10.1073/pnas.94.17.9249

PubMed ID: 11116084

Title: Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting.

PubMed ID: 11116084

DOI: 10.1101/gr.139200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15871461

Title: An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors.

PubMed ID: 15871461

DOI: 10.1093/dnares/11.6.381

PubMed ID: 15937339

Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.

PubMed ID: 15937339

DOI: 10.1074/jbc.m408571200

PubMed ID: 18260151

Title: Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain.

PubMed ID: 18260151

DOI: 10.1002/cne.21652

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22404850

Title: Evidence that Yih1 resides in a complex with ribosomes.

PubMed ID: 22404850

DOI: 10.1111/j.1742-4658.2012.08553.x

PubMed ID: 23447528

Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth.

PubMed ID: 23447528

DOI: 10.1074/jbc.m113.461970

PubMed ID: 24333428

Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

PubMed ID: 24333428

DOI: 10.1016/j.bbrc.2013.12.021

Sequence Information:

Length: 318
Mass: 36276
Checksum: F3A3688D87C88A40
Sequence:

MAEEEVGNSQ RQSEEIEAMA AIYGEEWCVI DENAKIFCIR VTDFMDDPKW TLCLQVMLPS 
EYPGTAPPSY QLNAPWLKGQ ERADLSNSLE EIYVHNMGES ILYQWVEKIR DALIQKSQIT 
EPDPDVKKKT EEVEVESEED PILEHPPENP VKTLDLKISE ETQPETEELP PVAHGVPITD 
RRSTFQAHVA PVVCPEQVKL VLAKLYENKK IASATHNIYA YRIFCEDKQT FLQDCEDDGE 
TAAGGRLLHL MEILNVKNVM VVVSRWYGGI LLGPDRFKHI NNCARNILVE KNFTNTPDES 
TKNLGKKKVK KDKKKNDH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Impact

Associated with

Other Information

Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. PubMed ID: 9256468

Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. PubMed ID: 11116084

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. PubMed ID: 15871461

IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation. PubMed ID: 15937339

Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain. PubMed ID: 18260151

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Evidence that Yih1 resides in a complex with ribosomes. PubMed ID: 22404850

IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth. PubMed ID: 23447528

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. PubMed ID: 24333428