Genular: Defining Cellular Identity and Function

Details for: Kpnb1

Gene ID: 16211

Symbol: Kpnb1

Ensembl ID: ENSMUSG00000001440

Description: karyopherin subunit beta 1

Associated with

Apoptosis
(R-MMU-109581)
Apoptosis induced dna fragmentation
(R-MMU-140342)
Apoptotic execution phase
(R-MMU-75153)
Assembly of the orc complex at the origin of replication
(R-MMU-68616)
Assembly of the pre-replicative complex
(R-MMU-68867)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cytokine signaling in immune system
(R-MMU-1280215)
Disease
(R-HSA-1643685)
Dna replication
(R-MMU-69306)
Dna replication pre-initiation
(R-MMU-69002)
Immune system
(R-MMU-168256)
Infectious disease
(R-HSA-5663205)
Initiation of nuclear envelope (ne) reformation
(R-MMU-2995383)
Innate immune system
(R-MMU-168249)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon signaling
(R-MMU-913531)
Maturation of hrsv a proteins
(R-HSA-9828806)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Neutrophil degranulation
(R-MMU-6798695)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Programmed cell death
(R-MMU-5357801)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-MMU-1655829)
Respiratory syncytial virus (rsv) genome replication, transcription and translation
(R-HSA-9820965)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Viral infection pathways
(R-HSA-9824446)
Astral microtubule organization
(GO:0030953)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Endoplasmic reticulum tubular network
(GO:0071782)
Enzyme binding
(GO:0019899)
Establishment of mitotic spindle localization
(GO:0040001)
Hsp90 protein binding
(GO:0051879)
Importin-alpha family protein binding
(GO:0061676)
Intracellular protein transport
(GO:0006886)
Kinesin binding
(GO:0019894)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle assembly
(GO:0090307)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear envelope
(GO:0005635)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nuclear pore
(GO:0005643)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein import into nucleus
(GO:0006606)
Protein transport
(GO:0015031)
Ribosomal protein import into nucleus
(GO:0006610)
Rna import into nucleus
(GO:0006404)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Importin subunit beta-1
Q3UHW8_MOUSE

Genular Protein ID: 117635304

Symbol: IMB1_MOUSE

Name: Importin subunit beta-1

UniProtKB Accession Codes:

P70168 Q62117 Q6GTI5

Database IDs:

Citations:

PubMed ID: 8812441

Title: Localization of the importin-beta gene to mouse chromosome 11D and rat chromosome 10q32.1.

PubMed ID: 8812441

DOI: 10.1006/geno.1996.0450

PubMed ID: 7635189

Title: The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile.

PubMed ID: 7635189

DOI: 10.1016/0014-5793(95)00699-a

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11493596

Title: Multiple pathways contribute to nuclear import of core histones.

PubMed ID: 11493596

DOI: 10.1093/embo-reports/kve168

PubMed ID: 11535586

Title: The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1.

PubMed ID: 11535586

DOI: 10.1074/jbc.m101668200

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20699224

Title: Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse.

PubMed ID: 20699224

DOI: 10.1074/jbc.m110.117044

PubMed ID: 25946333

Title: The inner nuclear membrane protein Nemp1 is a new type of RanGTP-binding protein in eukaryotes.

PubMed ID: 25946333

DOI: 10.1371/journal.pone.0127271

PubMed ID: 10964573

Title: The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport.

PubMed ID: 10964573

DOI: 10.1006/jmbi.2000.4055

PubMed ID: 14645851

Title: The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor.

PubMed ID: 14645851

DOI: 10.1126/science.1088372

Sequence Information:

Length: 876
Mass: 97184
Checksum: 00D6B15023A30598
Sequence:

MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE 
IPVSQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG 
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN 
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA 
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLSTCCE 
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GSILEGPEPN QLKPLVIQAM PTLIELMKDP 
SVVVRDTTAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA 
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNNLRSSAYE SLMEIVKNSA 
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA 
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN 
YAEYQVCLAA VGLVGDLCRA LQSNILPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI 
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DFDMVDYLNE LRESCLEAYT GIVQGLKGDQ 
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR 
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

Genular Protein ID: 2525365534

Symbol: Q3UHW8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UHW8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 876
Mass: 97157
Checksum: A53C12DE8B4DE786
Sequence:

MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IKNSLTSKDP DIKAQYQQRW LAIDANARRE VKNYVLQTLG TETYRPSSAS QCVAGIACAE 
IPVSQWPELI PQLVANVTNP NSTEHMKEST LEAIGYICQD IDPEQLQDKS NEILTAIIQG 
MRKEEPSNNV KLAATNALLN SLEFTKANFD KESERHFIMQ VVCEATQCPD TRVRVAALQN 
LVKIMSLYYQ YMETYMGPAL FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA 
AEQGRPPEHT SKFYAKGALQ YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLSTCCE 
DDIVPHVLPF IKEHIKNPDW RYRDAAVMAF GSILEGPEPN QLKPLVIQAM PTLIELMKDP 
SVVVRDTTAW TVGRICELLP EAAINDVYLA PLLQCLIEGL SAEPRVASNV CWAFSSLAEA 
AYEAADVADD QEEPATYCLS SSFELIVQKL LETTDRPDGH QNSLRSSAYE SLMEIVKNSA 
KDCYPAVQKT TLVIMERLQQ VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA 
LQISDVVMAS LLRMFQSTAG SGGVQEDALM AVSTLVEVLG GEFLKYMEAF KPFLGIGLKN 
YAEYQVCLAA VGLVGDLCRA LQSNILPFCD EVMQLLLENL GNENVHRSVK PQILSVFGDI 
ALAIGGEFKK YLEVVLNTLQ QASQAQVDKS DFDMVDYLNE LRESCLEAYT GIVQGLKGDQ 
ENVHPDVMLV QPRVEFILSF IDHIAGDEDH TDGVVACAAG LIGDLCTAFG KDVLKLVEAR 
PMIHELLTEG RRSKTNKAKT LATWATKELR KLKNQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kpnb1

Associated with

Other Information

Localization of the importin-beta gene to mouse chromosome 11D and rat chromosome 10q32.1. PubMed ID: 8812441

The nuclear pore-targeting complex binds to nuclear pores after association with a karyophile. PubMed ID: 7635189

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Multiple pathways contribute to nuclear import of core histones. PubMed ID: 11493596

The C-terminal nuclear localization signal of the sex-determining region Y (SRY) high mobility group domain mediates nuclear import through importin beta 1. PubMed ID: 11535586

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Novel importin-alpha family member Kpna7 is required for normal fertility and fecundity in the mouse. PubMed ID: 20699224

The inner nuclear membrane protein Nemp1 is a new type of RanGTP-binding protein in eukaryotes. PubMed ID: 25946333

The adoption of a twisted structure of importin-beta is essential for the protein-protein interaction required for nuclear transport. PubMed ID: 10964573

The structure of importin-beta bound to SREBP-2: nuclear import of a transcription factor. PubMed ID: 14645851

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073