DBN1 | ENSG00000113758 | NCBI 1627

Details for: DBN1

Gene ID: 1627

Symbol: DBN1

Ensembl ID: ENSG00000113758

Description: drebrin 1

Associated with

Rhobtb1 gtpase cycle
(R-HSA-9013422)
Rhobtb2 gtpase cycle
(R-HSA-9013418)
Rhobtb gtpase cycle
(R-HSA-9706574)
Rhod gtpase cycle
(R-HSA-9013405)
Rho gtpase cycle
(R-HSA-9012999)
Rhoh gtpase cycle
(R-HSA-9013407)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament organization
(GO:0007015)
Actomyosin
(GO:0042641)
Cadherin binding
(GO:0045296)
Cell communication by chemical coupling
(GO:0010643)
Cell communication by electrical coupling
(GO:0010644)
Cortical cytoskeleton
(GO:0030863)
Cytoplasm
(GO:0005737)
Cytoplasmic sequestering of protein
(GO:0051220)
Cytoskeleton
(GO:0005856)
Dendrite
(GO:0030425)
Gap junction
(GO:0005921)
Generation of neurons
(GO:0048699)
Glutamatergic synapse
(GO:0098978)
Growth cone
(GO:0030426)
In utero embryonic development
(GO:0001701)
Maintenance of protein location in cell
(GO:0032507)
Neural precursor cell proliferation
(GO:0061351)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of receptor localization to synapse
(GO:1902685)
Positive regulation of synaptic plasticity
(GO:0031915)
Postsynaptic cytosol
(GO:0099524)
Postsynaptic density
(GO:0014069)
Postsynaptic membrane
(GO:0045211)
Profilin binding
(GO:0005522)
Protein binding
(GO:0005515)
Regulation of dendrite development
(GO:0050773)
Regulation of neuronal synaptic plasticity
(GO:0048168)

Other Information

Proteins

Drebrin

Genular Protein ID: 189393879

Symbol: DREB_HUMAN

Name: Drebrin

UniProtKB Accession Codes:

Q16643 A8MV58 B2RBG0 Q9UFZ5

Database IDs:

Citations:

PubMed ID: 8216329

Title: Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene.

PubMed ID: 8216329

DOI: 10.1006/bbrc.1993.2273

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 8838578

Title: Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease.

PubMed ID: 8838578

DOI: 10.1002/jnr.490430111

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20215400

Title: F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse.

PubMed ID: 20215400

DOI: 10.1242/jcs.064238

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 35916866

Title: De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations.

PubMed ID: 35916866

DOI: 10.1016/j.gim.2022.06.001

PubMed ID: 28966017

Title: The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin.

PubMed ID: 28966017

DOI: 10.1016/j.str.2017.08.014

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 649
Mass: 71429
Checksum: A7DF1AE3776C0BEA
Sequence:

MAGVSFSGHR LELLAAYEEV IREESAADWA LYTYEDGSDD LKLAASGEGG LQELSGHFEN 
QKVMYGFCSV KDSQAALPKY VLINWVGEDV PDARKCACAS HVAKVAEFFQ GVDVIVNASS 
VEDIDAGAIG QRLSNGLARL SSPVLHRLRL REDENAEPVG TTYQKTDAAV EMKRINREQF 
WEQAKKEEEL RKEEERKKAL DERLRFEQER MEQERQEQEE RERRYREREQ QIEEHRRKQQ 
TLEAEEAKRR LKEQSIFGDH RDEEEETHMK KSESEVEEAA AIIAQRPDNP REFFKQQERV 
ASASAGSCDV PSPFNHRPGS HLDSHRRMAP TPIPTRSPSD SSTASTPVAE QIERALDEVT 
SSQPPPLPPP PPPAQETQEP SPILDSEETR AAAPQAWAGP MEEPPQAQAP PRGPGSPAED 
LMFMESAEQA VLAAPVEPAT ADATEIHDAA DTIETDTATA DTTVANNVPP AATSLIDLWP 
GNGEGASTLQ GEPRAPTPPS GTEVTLAEVP LLDEVAPEPL LPAGEGCATL LNFDELPEPP 
ATFCDPEEVE GESLAAPQTP TLPSALEELE QEQEPEPHLL TNGETTQKEG TQASEGYFSQ 
SQEEEFAQSE ELCAKAPPPV FYNKPPEIDI TCWDADPVPE EEEGFEGGD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DBN1

Associated with

Other Information

Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. PubMed ID: 8216329

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Disappearance of actin-binding protein, drebrin, from hippocampal synapses in Alzheimer's disease. PubMed ID: 8838578

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

Phosphoproteome of resting human platelets. PubMed ID: 18088087

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse. PubMed ID: 20215400

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

De Novo ZMYND8 variants result in an autosomal dominant neurodevelopmental disorder with cardiac malformations. PubMed ID: 35916866

The Structure of the ZMYND8/Drebrin Complex Suggests a Cytoplasmic Sequestering Mechanism of ZMYND8 by Drebrin. PubMed ID: 28966017

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974