Details for: DBP

Gene ID: 1628

Symbol: DBP

Ensembl ID: ENSG00000105516

Description: D-box binding PAR bZIP transcription factor

Associated with

  • Bmal1:clock,npas2 activates circadian gene expression
    (R-HSA-1368108)
  • Circadian clock
    (R-HSA-400253)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.95
    Marker Score: 3559
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.72
    Marker Score: 5531
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.31
    Marker Score: 2178
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.4
    Marker Score: 5180
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2474
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2876
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.22
    Marker Score: 1691
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.14
    Marker Score: 357
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17451
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.09
    Marker Score: 570
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.09
    Marker Score: 350
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.05
    Marker Score: 11832
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71752
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47976
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.97
    Marker Score: 1076
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.97
    Marker Score: 1047
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.97
    Marker Score: 289
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.95
    Marker Score: 569
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2713
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5251
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4940
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1747
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.86
    Marker Score: 5091.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.83
    Marker Score: 825
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 566
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.83
    Marker Score: 871
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.77
    Marker Score: 380
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 374
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.72
    Marker Score: 882
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.71
    Marker Score: 4637
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.7
    Marker Score: 292
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 328
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2815
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.67
    Marker Score: 479
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 610
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.66
    Marker Score: 6664
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.64
    Marker Score: 1115
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.62
    Marker Score: 1763
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.6
    Marker Score: 648
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.59
    Marker Score: 627
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.59
    Marker Score: 757
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.58
    Marker Score: 337
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.58
    Marker Score: 150
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.57
    Marker Score: 883
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.57
    Marker Score: 1550
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.56
    Marker Score: 136.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.56
    Marker Score: 242
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.55
    Marker Score: 126
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 431
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.53
    Marker Score: 3920
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.52
    Marker Score: 183
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.52
    Marker Score: 529
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.52
    Marker Score: 165
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.52
    Marker Score: 5363
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.51
    Marker Score: 2152
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.51
    Marker Score: 253
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 887
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.5
    Marker Score: 910
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 817
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.49
    Marker Score: 465
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.48
    Marker Score: 7247
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.48
    Marker Score: 4145
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 211
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.47
    Marker Score: 411
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.47
    Marker Score: 303
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.46
    Marker Score: 406
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1222
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.45
    Marker Score: 1323
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.45
    Marker Score: 208
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 27091
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.44
    Marker Score: 2111
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.44
    Marker Score: 478
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.44
    Marker Score: 308
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.43
    Marker Score: 635
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.43
    Marker Score: 128
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 409
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.42
    Marker Score: 1067
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.42
    Marker Score: 92
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.42
    Marker Score: 448
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.42
    Marker Score: 285
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.42
    Marker Score: 337
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.42
    Marker Score: 952
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.41
    Marker Score: 275
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.41
    Marker Score: 124
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.41
    Marker Score: 199
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.4
    Marker Score: 97
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1627
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.4
    Marker Score: 93

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Other Information

**Key characteristics:** - DBP is a transcription factor that is expressed in a variety of cell types. - It is a key component of the circadian clock and is involved in the regulation of numerous physiological and behavioral processes. - It is a D-box binding protein and is responsible for binding to DNA sequences known as D-boxes. - It is a key regulator of transcription and is involved in the regulation of many genes involved in circadian rhythms. **Pathways and functions:** - DBP is a key regulator of the circadian clock. - It is involved in the regulation of the expression of genes involved in the circadian clock, including Bmal1, clock, and suprachiasmatic nucleus (SCN). - It also plays a role in the regulation of other physiological processes, such as metabolism, growth, and development. **Clinical significance:** - Mutations in DBP have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - Targeting DBP has been investigated as a potential therapeutic strategy for these disorders. - DBP is a promising target for the development of new drugs that could treat these disorders.

Genular Protein ID: 1457252278

Symbol: DBP_HUMAN

Name: D site-binding protein

UniProtKB Accession Codes:

Q10586 A2I2P4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7835883

Title: Chromosomal localization and cDNA cloning of the human DBP and TEF genes.

PubMed ID: 7835883

DOI: 10.1006/geno.1994.1510

PubMed ID: 8786133

Title: Genomic structure of the human D-site binding protein (DBP) gene.

PubMed ID: 8786133

DOI: 10.1006/geno.1996.0295

PubMed ID: 9110174

Title: Large-scale concatenation cDNA sequencing.

PubMed ID: 9110174

DOI: 10.1101/gr.7.4.353

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8482542

Title: Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I.

PubMed ID: 8482542

DOI: 10.1016/0378-1119(93)90375-d

PubMed ID: 10508692

Title: The ins and outs of circadian timekeeping.

PubMed ID: 10508692

DOI: 10.1016/s0959-437x(99)00009-x

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 325
  • Mass: 34349
  • Checksum: A6933CE21399ECF3
  • Sequence:
    • MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK EKERKAALPA 
ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL APLLWERTLP FGDVEYVDLD 
AFLLEHGLPP SPPPPGGPSP EPSPARTPAP SPGPGSCGSA SPRSSPGHAP ARAALGTASG 
HRAGLTSRDT PSPVDPDTVE VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI 
MKKARKIQVP EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE 
VVAVRQELSH YRAVLSRYQA QHGAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.