Details for: AP2B1

Gene ID: 163

Symbol: AP2B1

Ensembl ID: ENSG00000006125

Description: adaptor related protein complex 2 subunit beta 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 381.1110
    Cell Significance Index: -59.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 268.2901
    Cell Significance Index: -68.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 157.7628
    Cell Significance Index: -64.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.0990
    Cell Significance Index: -74.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 145.5236
    Cell Significance Index: -59.1200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 130.8747
    Cell Significance Index: -67.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 61.9696
    Cell Significance Index: -59.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 56.5470
    Cell Significance Index: -69.7200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.0816
    Cell Significance Index: -67.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.6212
    Cell Significance Index: -73.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.8482
    Cell Significance Index: -54.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2192
    Cell Significance Index: -31.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.8247
    Cell Significance Index: 562.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3731
    Cell Significance Index: 476.0400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2126
    Cell Significance Index: 272.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.9746
    Cell Significance Index: 355.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8266
    Cell Significance Index: 655.1900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5975
    Cell Significance Index: 173.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3377
    Cell Significance Index: 82.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3150
    Cell Significance Index: 213.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2814
    Cell Significance Index: 58.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2070
    Cell Significance Index: 834.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1996
    Cell Significance Index: 238.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0886
    Cell Significance Index: 10.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9937
    Cell Significance Index: 136.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9607
    Cell Significance Index: 524.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.8703
    Cell Significance Index: 64.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7960
    Cell Significance Index: 61.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7761
    Cell Significance Index: 19.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7510
    Cell Significance Index: 18.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7185
    Cell Significance Index: 40.3200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6673
    Cell Significance Index: 16.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6513
    Cell Significance Index: 28.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6341
    Cell Significance Index: 17.2600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5960
    Cell Significance Index: 76.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5778
    Cell Significance Index: 21.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5354
    Cell Significance Index: 36.0000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5175
    Cell Significance Index: 3.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4948
    Cell Significance Index: 25.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4832
    Cell Significance Index: 10.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4389
    Cell Significance Index: 43.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3822
    Cell Significance Index: 168.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3302
    Cell Significance Index: 15.5200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.2894
    Cell Significance Index: 3.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2324
    Cell Significance Index: 4.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2316
    Cell Significance Index: 10.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1526
    Cell Significance Index: 26.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1488
    Cell Significance Index: 7.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1393
    Cell Significance Index: 262.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1192
    Cell Significance Index: 22.6800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1167
    Cell Significance Index: 4.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0894
    Cell Significance Index: 40.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0857
    Cell Significance Index: 54.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0831
    Cell Significance Index: 153.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0808
    Cell Significance Index: 124.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0690
    Cell Significance Index: 4.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0429
    Cell Significance Index: 58.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0058
    Cell Significance Index: 4.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0279
    Cell Significance Index: -0.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0288
    Cell Significance Index: -0.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0311
    Cell Significance Index: -23.0600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0414
    Cell Significance Index: -5.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0446
    Cell Significance Index: -33.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0531
    Cell Significance Index: -0.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0710
    Cell Significance Index: -44.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0833
    Cell Significance Index: -46.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1314
    Cell Significance Index: -3.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1628
    Cell Significance Index: -10.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1671
    Cell Significance Index: -11.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1725
    Cell Significance Index: -20.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1789
    Cell Significance Index: -37.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1804
    Cell Significance Index: -18.4300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1986
    Cell Significance Index: -4.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2118
    Cell Significance Index: -2.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.2322
    Cell Significance Index: -1.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2358
    Cell Significance Index: -34.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2529
    Cell Significance Index: -72.7600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3466
    Cell Significance Index: -7.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3564
    Cell Significance Index: -40.8300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4592
    Cell Significance Index: -6.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5461
    Cell Significance Index: -9.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5877
    Cell Significance Index: -61.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6116
    Cell Significance Index: -69.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6146
    Cell Significance Index: -48.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6234
    Cell Significance Index: -17.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7047
    Cell Significance Index: -18.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8002
    Cell Significance Index: -41.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8407
    Cell Significance Index: -17.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0012
    Cell Significance Index: -21.6900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0024
    Cell Significance Index: -29.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0229
    Cell Significance Index: -6.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0622
    Cell Significance Index: -65.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1112
    Cell Significance Index: -23.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.1488
    Cell Significance Index: -68.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1817
    Cell Significance Index: -31.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2242
    Cell Significance Index: -39.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2470
    Cell Significance Index: -18.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2540
    Cell Significance Index: -41.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2553
    Cell Significance Index: -39.9800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.3193
    Cell Significance Index: -28.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **AP-2 complex subunit**: AP2B1 is a subunit of the adaptor protein complex 2 (AP-2), which plays a critical role in regulating the internalization of receptors and vesicle trafficking. 2. **Endocytosis**: AP2B1 is involved in the clathrin-mediated endocytosis of receptors, facilitating their internalization and recycling. 3. **Signal transduction**: AP2B1 interacts with various signaling pathways, including Wnt, Eph-ephrin, and NTRK1 (TRKA), to regulate cell signaling and synaptic plasticity. 4. **Immune system function**: AP2B1 is expressed in immune cells and interacts with HIV-1 proteins, such as Nef, to modulate cell surface receptor expression and immune responses. 5. **Neural development and function**: AP2B1 is significantly expressed in Purkinje cells, GABAergic cortical interneurons, and vascular leptomeningeal cells, suggesting its involvement in neural development and function. **Pathways and Functions** 1. **Clathrin-mediated endocytosis**: AP2B1 regulates the internalization of receptors, such as glutamate receptors, through clathrin-mediated endocytosis. 2. **Wnt signaling**: AP2B1 interacts with Wnt proteins to regulate cell signaling and development. 3. **Eph-ephrin signaling**: AP2B1 is involved in the regulation of Eph-ephrin-mediated cell repulsion and adhesion. 4. **NTRK1 (TRKA) signaling**: AP2B1 interacts with NTRK1 to regulate cell signaling and synaptic plasticity. 5. **Immune responses**: AP2B1 interacts with HIV-1 proteins, such as Nef, to modulate cell surface receptor expression and immune responses. **Clinical Significance** 1. **HIV-1 infection**: AP2B1 plays a critical role in HIV-1 infection, where it interacts with the viral Nef protein to modulate cell surface receptor expression and immune responses. 2. **Neurological disorders**: AP2B1 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Cancer**: AP2B1 has been shown to interact with various cancer-related proteins, including those involved in cell signaling and immune responses. 4. **Infectious diseases**: AP2B1 has been implicated in the regulation of immune responses to infectious diseases, including HIV-1 and other viral infections. In conclusion, AP2B1 is a multifunctional gene that plays a critical role in various cellular processes, including endocytosis, signal transduction, and immune system function. Its dysregulation has been implicated in various diseases, including HIV-1 infection, neurological disorders, and cancer. Further research is needed to fully understand the mechanisms by which AP2B1 regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 2912025322

Symbol: AP2B1_HUMAN

Name: AP-2 complex subunit beta

UniProtKB Accession Codes:

P63010 A6NJP3 P21851 Q7Z451 Q96J19

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 6 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 22 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 14 RefSeq 7 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1969413

Title: Conservation and diversity in families of coated vesicle adaptins.

PubMed ID: 1969413

DOI: 10.1016/s0021-9258(19)34045-1

PubMed ID: 15897975

Title: Expression of a novel beta adaptin subunit mRNA splice variant in human testes.

PubMed ID: 15897975

DOI: 10.1111/j.1745-7262.2005.00025.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11777907

Title: beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binding site in beta 2-adaptin.

PubMed ID: 11777907

DOI: 10.1074/jbc.m108490200

PubMed ID: 12429842

Title: Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit.

PubMed ID: 12429842

DOI: 10.1091/mbc.02-07-0104

PubMed ID: 14745134

Title: Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network.

PubMed ID: 14745134

DOI: 10.1247/csf.28.419

PubMed ID: 14530274

Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.

PubMed ID: 14530274

DOI: 10.1074/jbc.c300390200

PubMed ID: 15473838

Title: Adaptors for clathrin coats: structure and function.

PubMed ID: 15473838

DOI: 10.1146/annurev.cellbio.20.010403.104543

PubMed ID: 14985334

Title: Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference.

PubMed ID: 14985334

DOI: 10.1074/jbc.c400046200

PubMed ID: 15728179

Title: Functional dissection of an AP-2 beta2 appendage-binding sequence within the autosomal recessive hypercholesterolemia protein.

PubMed ID: 15728179

DOI: 10.1074/jbc.m501029200

PubMed ID: 16723738

Title: Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex.

PubMed ID: 16723738

DOI: 10.1242/jcs.02943

PubMed ID: 17719203

Title: ARF6 regulates angiotensin II type 1 receptor endocytosis by controlling the recruitment of AP-2 and clathrin.

PubMed ID: 17719203

DOI: 10.1016/j.cellsig.2007.07.015

PubMed ID: 17456551

Title: Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

PubMed ID: 17456551

DOI: 10.1242/jcs.03444

PubMed ID: 19033387

Title: The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway.

PubMed ID: 19033387

DOI: 10.1242/jcs.033522

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18938240

Title: c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway.

PubMed ID: 18938240

DOI: 10.1016/j.cellsig.2008.09.013

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20154091

Title: The connecdenn family, Rab35 guanine nucleotide exchange factors interfacing with the clathrin machinery.

PubMed ID: 20154091

DOI: 10.1074/jbc.m109.050930

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23676497

Title: Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease.

PubMed ID: 23676497

DOI: 10.1172/jci65401

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27022195

Title: Raftlin controls lipopolysaccharide-induced TLR4 internalization and TICAM-1 signaling in a cell type-specific manner.

PubMed ID: 27022195

DOI: 10.4049/jimmunol.1501734

PubMed ID: 29262337

Title: APache is an AP2-interacting protein involved in synaptic vesicle trafficking and neuronal development.

PubMed ID: 29262337

DOI: 10.1016/j.celrep.2017.11.073

PubMed ID: 10944104

Title: The structure and function of the beta 2-adaptin appendage domain.

PubMed ID: 10944104

DOI: 10.1093/emboj/19.16.4216

PubMed ID: 12086608

Title: Molecular architecture and functional model of the endocytic AP2 complex.

PubMed ID: 12086608

DOI: 10.1016/s0092-8674(02)00735-3

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

PubMed ID: 19140243

Title: A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex.

PubMed ID: 19140243

DOI: 10.1038/nature07422

Sequence Information:

  • Length: 937
  • Mass: 104553
  • Checksum: B472EE5B2AE176DF
  • Sequence:
    • MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT 
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE 
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA 
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI 
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY 
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK 
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV 
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST 
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL 
DSLVGQSFIP SSVPATFAPS PTPAVVSSGL NDLFELSTGI GMAPGGYVAP KAVWLPAVKA 
KGLEISGTFT HRQGHIYMEM NFTNKALQHM TDFAIQFNKN SFGVIPSTPL AIHTPLMPNQ 
SIDVSLPLNT LGPVMKMEPL NNLQVAVKNN IDVFYFSCLI PLNVLFVEDG KMERQVFLAT 
WKDIPNENEL QFQIKECHLN ADTVSSKLQN NNVYTIAKRN VEGQDMLYQS LKLTNGIWIL 
AELRIQPGNP NYTLSLKCRA PEVSQYIYQV YDSILKN

Genular Protein ID: 2391871084

Symbol: A0A140VJE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJE8

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 11 Gene3D 3 IntAct 1 InterPro 12 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 Pfam 3 RefSeq 3 SMART 5 SMR 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 951
  • Mass: 105692
  • Checksum: 3199C9F8C7F027F2
  • Sequence:
    • MTDSKYFTTN KKGEIFELKA ELNNEKKEKR KEAVKKVIAA MTVGKDVSSL FPDVVNCMQT 
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNS FVKDCEDPNP LIRALAVRTM GCIRVDKITE 
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQMVEDQG FLDSLRDLIA DSNPMVVANA 
VAALSEISES HPNSNLLDLN PQNINKLLTA LNECTEWGQI FILDCLSNYN PKDDREAQSI 
CERVTPRLSH ANSAVVLSAV KVLMKFLELL PKDSDYYNML LKKLAPPLVT LLSGEPEVQY 
VALRNINLIV QKRPEILKQE IKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE 
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIRDIFRK 
YPNKYESIIA TLCENLDSLD EPDARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV 
QLTLLTAIVK LFLKKPSETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVTAKEV 
VLSEKPLISE ETDLIEPTLL DELICHIGSL ASVYHKPPNA FVEGSHGIHR KHLPIHHGST 
DAGDSPVGTT TATNLEQPQV IPSQGDLLGD LLNLDLGPPV NVPQVSSMQM GAVDLLGGGL 
DSLLGSDLGG GIGGSPAVGQ SFIPSSVPAT FAPSPTPAVV SSGLNDLFEL STGIGMAPGG 
YVAPKAVWLP AVKAKGLEIS GTFTHRQGHI YMEMNFTNKA LQHMTDFAIQ FNKNSFGVIP 
STPLAIHTPL MPNQSIDVSL PLNTLGPVMK MEPLNNLQVA VKNNIDVFYF SCLIPLNVLF 
VEDGKMERQV FLATWKDIPN ENELQFQIKE CHLNADTVSS KLQNNNVYTI AKRNVEGQDM 
LYQSLKLTNG IWILAELRIQ PGNPNYTLSL KCRAPEVSQY IYQVYDSILK N

Genular Protein ID: 4071329008

Symbol: Q96EL6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96EL6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 3 Google 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SMART 4 SUPFAM 3

Sequence Information:

  • Length: 556
  • Mass: 61083
  • Checksum: 9B1818042C855A32
  • Sequence:
    • LDLIQTKVNY VVQEAIVVIR DIFRKYPNKY ESIIATLCEN LDSLDEPDAR AAMIWIVGEY 
AERIDNADEL LESFLEGFHD ESTQVQLTLL TAIVKLFLKK PSETQELVQQ VLSLATQDSD 
NPDLRDRGYI YWRLLSTDPV TAKEVVLSEK PLISEETDLI EPTLLDELIC HIGSLASVYH 
KPPNAFVEGS HGIHRKHLPI HHGSTDAGDS PVGTTTATNL EQPQVIPSQG DLLGDLLNLD 
LGPPVNVPQV SSMQMGAVDL LGGGLDSLLG SDLGGGIGGS PAVGQSFIPS SVPATFAPSP 
TPAVVSSGLN DLFELSTGIG MAPGGYVAPK AVWLPAVKAK GLEISGTFTH RQGHIYMEMN 
FTNKALQHMT DFAIQFNKNS FGVIPSTPLA IHTPLMPNQS IDVSLPLNTL GPVMKMEPLN 
NLQVAVKNNI DVFYFSCLIP LNVLFVEDGK MERQVFLATW KDIPNENELQ FQIKECHLNA 
DTVSSKLQNN NVYTIAKRNV EGQDMLYQSL KLTNGIWILA ELRIQPGNPN YTLSLKCRAP 
EVSQYIYQVY DSILKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.