Details for: Inpp5d
Associated with
Other Information
Genular Protein ID: 1159229924
Symbol: SHIP1_MOUSE
Name: Inositol polyphosphate-5-phosphatase D
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8654924
Title: p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
PubMed ID: 8654924
PubMed ID: 8643691
Title: The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.
PubMed ID: 8643691
PubMed ID: 9027494
Title: Molecular cloning and chromosomal localization in human and mouse of the SH2-containing inositol phosphatase, INPP5D (SHIP).
PubMed ID: 9027494
PubMed ID: 10068665
Title: A novel spliced form of SH2-containing inositol phosphatase is expressed during myeloid development.
PubMed ID: 10068665
PubMed ID: 11013080
Title: Cloning of the genomic locus of mouse SH2 containing inositol 5-phosphatase (SHIP) and a novel 110-kDa splice isoform, SHIPdelta.
PubMed ID: 11013080
PubMed ID: 11567986
Title: Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein.
PubMed ID: 11567986
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8632995
Title: Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains.
PubMed ID: 8632995
PubMed ID: 8723348
Title: Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
PubMed ID: 8723348
PubMed ID: 8805703
Title: Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fc(gamma)RIIB.
PubMed ID: 8805703
DOI: 10.1038/383263a0
PubMed ID: 8805618
Title: Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.
PubMed ID: 8805618
PubMed ID: 9244303
Title: Deletion of SHIP or SHP-1 reveals two distinct pathways for inhibitory signaling.
PubMed ID: 9244303
PubMed ID: 9083021
Title: The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis.
PubMed ID: 9083021
PubMed ID: 9099679
Title: Shc interaction with Src homology 2 domain containing inositol phosphatase (SHIP) in vivo requires the Shc-phosphotyrosine binding domain and two specific phosphotyrosines on SHIP.
PubMed ID: 9099679
PubMed ID: 9110989
Title: Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2.
PubMed ID: 9110989
PubMed ID: 9367159
Title: A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate.
PubMed ID: 9367159
DOI: 10.1038/36621
PubMed ID: 9485206
Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.
PubMed ID: 9485206
DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o
PubMed ID: 11247302
Title: Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.
PubMed ID: 11247302
PubMed ID: 17947660
Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.
PubMed ID: 17947660
PubMed ID: 19144319
Title: The phagosomal proteome in interferon-gamma-activated macrophages.
PubMed ID: 19144319
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20526344
Title: An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions.
PubMed ID: 20526344
DOI: 10.1038/ni.1886
PubMed ID: 9341117
Title: Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets.
PubMed ID: 9341117
PubMed ID: 9393882
Title: The phosphatidylinositol polyphosphate 5-phosphatase SHIP and the protein tyrosine phosphatase SHP-2 form a complex in hematopoietic cells which can be regulated by BCR/ABL and growth factors.
PubMed ID: 9393882
PubMed ID: 9694708
Title: Multiple forms of the SH2-containing inositol phosphatase, SHIP, are generated by C-terminal truncation.
PubMed ID: 9694708
PubMed ID: 9531585
Title: The SH2-containing inositol polyphosphate 5-phosphatase, ship, is expressed during hematopoiesis and spermatogenesis.
PubMed ID: 9531585
PubMed ID: 9857188
Title: Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells.
PubMed ID: 9857188
PubMed ID: 9763612
Title: The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.
PubMed ID: 9763612
PubMed ID: 9736736
Title: The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation.
PubMed ID: 9736736
PubMed ID: 9620849
Title: Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span.
PubMed ID: 9620849
PubMed ID: 10395202
Title: Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells.
PubMed ID: 10395202
PubMed ID: 10794720
Title: pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of alphaIIbbeta3 integrin in human platelets.
PubMed ID: 10794720
DOI: 10.1042/bj3480107
PubMed ID: 10660611
Title: The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.
PubMed ID: 10660611
PubMed ID: 11016922
Title: Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.
PubMed ID: 11016922
PubMed ID: 10779347
Title: Essential role for the C-terminal noncatalytic region of SHIP in FcgammaRIIB1-mediated inhibitory signaling.
PubMed ID: 10779347
PubMed ID: 11222379
Title: SHIP's C-terminus is essential for its hydrolysis of PIP3 and inhibition of mast cell degranulation.
PubMed ID: 11222379
PubMed ID: 11031258
Title: SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates migration through two critical tyrosine residues and forms a novel signaling complex with DOK1 and CRKL.
PubMed ID: 11031258
PubMed ID: 11359765
Title: Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB.
PubMed ID: 11359765
PubMed ID: 11136821
Title: A regulatory role for Src homology 2 domain-containing inositol 5'-phosphatase (SHIP) in phagocytosis mediated by Fc gamma receptors and complement receptor 3 (alpha(M)beta(2); CD11b/CD18).
PubMed ID: 11136821
DOI: 10.1084/jem.193.1.61
PubMed ID: 12393695
Title: SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells.
PubMed ID: 12393695
PubMed ID: 12370370
Title: Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells.
PubMed ID: 12370370
PubMed ID: 12447389
Title: Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.
PubMed ID: 12447389
DOI: 10.1038/ncb885
PubMed ID: 12161749
Title: SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts.
PubMed ID: 12161749
DOI: 10.1038/nm752
PubMed ID: 11896575
Title: The SH2-containing inositol 5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells.
PubMed ID: 11896575
PubMed ID: 12882960
Title: The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity.
PubMed ID: 12882960
PubMed ID: 15166241
Title: SHIP1 and Lyn kinase negatively regulate integrin alpha IIb beta 3 signaling in platelets.
PubMed ID: 15166241
PubMed ID: 15456754
Title: Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.
PubMed ID: 15456754
PubMed ID: 15492005
Title: SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.
PubMed ID: 15492005
PubMed ID: 14993273
Title: Inhibition of the Jun N-terminal protein kinase pathway by SHIP-1, a lipid phosphatase that interacts with the adaptor molecule Dok-3.
PubMed ID: 14993273
PubMed ID: 16000869
Title: Inositol 5'-phosphatase, SHIP1 interacts with phospholipase C-gamma1 and modulates EGF-induced PLC activity.
PubMed ID: 16000869
DOI: 10.1038/emm.2005.22
PubMed ID: 16406061
Title: The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation.
PubMed ID: 16406061
PubMed ID: 17142780
Title: SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27.
PubMed ID: 17142780
PubMed ID: 17105399
Title: s-SHIP associates with receptor complexes essential for pluripotent stem cell growth and survival.
PubMed ID: 17105399
PubMed ID: 17173042
Title: Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1.
PubMed ID: 17173042
DOI: 10.1038/ncb1515
Sequence Information:
- Length: 1191
- Mass: 133542
- Checksum: AF9F21326A59EC7A
- Sequence:
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR NCVYTYRILP NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL QYPVPLEEED AIDEAEEDTV ESVMSPPELP PRNIPMSAGP SEAKDLPLAT ENPRAPEVTR LSLSETLFQR LQSMDTSGLP EEHLKAIQDY LSTQLLLDSD FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL FDQQLSPGLR PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL IKSQKFLNKL VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE QPEPDMITIF IGTWNMGNAP PPKKITSWFL SKGQGKTRDD SADYIPHDIY VIGTQEDPLG EKEWLELLRH SLQEVTSMTF KTVAIHTLWN IRIVVLAKPE HENRISHICT DNVKTGIANT LGNKGAVGVS FMFNGTSLGF VNSHLTSGSE KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE RLTRDKYAYT KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM TSDHSPVFAT FEAGVTSQFV SKNGPGTVDS QGQIEFLACY ATLKTKSQTK FYLEFHSSCL ESFVKSQEGE NEEGSEGELV VRFGETLPKL KPIISDPEYL LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL THHGEMTGHF RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG RVPACGVSSL NEMINPNYIG MGPFGQPLHG KSTLSPDQQL TAWSYDQLPK DSSLGPGRGE GPPTPPSQPP LSPKKFSSST ANRGPCPRVQ EARPGDLGKV EALLQEDLLL TKPEMFENPL YGSVSSFPKL VPRKEQESPK MLRKEPPPCP DPGISSPSIV LPKAQEVESV KGTSKQAPVP VLGPTPRIRS FTCSSSAEGR MTSGDKSQGK PKASASSQAP VPVKRPVKPS RSEMSQQTTP IPAPRPPLPV KSPAVLQLQH SKGRDYRDNT ELPHHGKHRQ EEGLLGRTAM Q
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.