Inppl1 | ENSMUSG00000032737 | NCBI 16332

Details for: Inppl1

Gene ID: 16332

Symbol: Inppl1

Ensembl ID: ENSMUSG00000032737

Description: inositol polyphosphate phosphatase-like 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Inositol phosphate metabolism
(R-MMU-1483249)
Interleukin-2 family signaling
(R-MMU-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-MMU-512988)
Interleukin receptor shc signaling
(R-MMU-912526)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Pi metabolism
(R-MMU-1483255)
Signaling by interleukins
(R-MMU-449147)
Synthesis of ip3 and ip4 in the cytosol
(R-MMU-1855204)
Synthesis of pips at the plasma membrane
(R-MMU-1660499)
Actin binding
(GO:0003779)
Actin filament organization
(GO:0007015)
Apoptotic process
(GO:0006915)
Catalytic activity
(GO:0003824)
Cell adhesion
(GO:0007155)
Cell projection
(GO:0042995)
Cellular lipid metabolic process
(GO:0044255)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endochondral ossification
(GO:0001958)
Endocytosis
(GO:0006897)
Erk1 and erk2 cascade
(GO:0070371)
Gene expression
(GO:0010467)
Glucose metabolic process
(GO:0006006)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Immune system process
(GO:0002376)
Inositol-polyphosphate 5-phosphatase activity
(GO:0004445)
Inositol trisphosphate metabolic process
(GO:0032957)
Lamellipodium
(GO:0030027)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna replication
(GO:0008156)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin-like growth factor receptor signaling pathway
(GO:0043569)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Nucleus
(GO:0005634)
Phosphatase activity
(GO:0016791)
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
(GO:0034485)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol biosynthetic process
(GO:0006661)
Phosphatidylinositol dephosphorylation
(GO:0046856)
Plasma membrane
(GO:0005886)
Post-embryonic development
(GO:0009791)
Protein binding
(GO:0005515)
Regulation of immune response
(GO:0050776)
Response to insulin
(GO:0032868)
Ruffle assembly
(GO:0097178)
Sh2 domain binding
(GO:0042169)
Sh3 domain binding
(GO:0017124)

Other Information

Proteins

SHIP2_MOUSE

Genular Protein ID: 2923074458

Symbol: SHIP2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6P549 O08611 Q0VDX5 Q80YB9 Q9JLL7

Database IDs:

Citations:

PubMed ID: 10610720

Title: The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse.

PubMed ID: 10610720

DOI: 10.1006/geno.1999.5995

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9126384

Title: Examining the specificity of Src homology 3 domain -- ligand interactions with alkaline phosphatase fusion proteins.

PubMed ID: 9126384

DOI: 10.1006/abio.1997.2040

PubMed ID: 9485206

Title: Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases.

PubMed ID: 9485206

DOI: 10.1002/(sici)1521-4141(199801)28:01<264::aid-immu264>3.0.co;2-o

PubMed ID: 10789675

Title: The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling.

PubMed ID: 10789675

DOI: 10.1016/s0165-2478(00)00162-0

PubMed ID: 10958682

Title: 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.

PubMed ID: 10958682

DOI: 10.1128/mcb.20.18.6860-6871.2000

PubMed ID: 11343120

Title: The lipid phosphatase SHIP2 controls insulin sensitivity.

PubMed ID: 11343120

DOI: 10.1038/35051094

PubMed ID: 12145149

Title: Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice.

PubMed ID: 12145149

DOI: 10.2337/diabetes.51.8.2387

PubMed ID: 14744864

Title: SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.

PubMed ID: 14744864

DOI: 10.1074/jbc.m311534200

PubMed ID: 15456754

Title: Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap.

PubMed ID: 15456754

DOI: 10.1074/jbc.m410261200

PubMed ID: 15492005

Title: SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase.

PubMed ID: 15492005

DOI: 10.1074/jbc.m408141200

PubMed ID: 15557176

Title: SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling.

PubMed ID: 15557176

DOI: 10.4049/jimmunol.173.11.6820

PubMed ID: 15654325

Title: Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

PubMed ID: 15654325

DOI: 10.1038/nm1178

PubMed ID: 16179375

Title: The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1.

PubMed ID: 16179375

DOI: 10.1182/blood-2005-05-1841

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21624956

Title: SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.

PubMed ID: 21624956

DOI: 10.1083/jcb.201012161

PubMed ID: 29749928

Title: Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions.

PubMed ID: 29749928

DOI: 10.7554/elife.35677

Sequence Information:

Length: 1257
Mass: 138973
Checksum: B66DF96BEF22F01E
Sequence:

MASVCGTPSP GGALGSPAPA WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV 
LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE 
REPDPPDDRD ASDVEDEKPP LPPRSGSTSI SAPVGPSSPL PTPETPTTPA AESTPNGLST 
VSHEYLKGSY GLDLEAVRGG ASNLPHLTRT LVTSCRRLHS EVDKVLSGLE ILSKVFDQQS 
SPMVTRLLQQ QSLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPLQP 
SIRKAKTIPV QAFEVKLDVT LGDLTKIGKS QKFTLSVDVE GGRLVLLRRQ RDSQEDWTTF 
THDRIRQLIK SQRVQNKLGV VFEKEKDRTQ RKDFIFVSAR KREAFCQLLQ LMKNRHSKQD 
EPDMISVFIG TWNMGSVPPP KNVTSWFTSK GLGKALDEVT VTIPHDIYVF GTQENSVGDR 
EWLDLLRGGL KELTDLDYRP IAMQSLWNIK VAVLVKPEHE NRISHVSTSS VKTGIANTLG 
NKGAVGVSFM FNGTSFGFVN CHLTSGNEKT TRRNQNYLDI LRLLSLGDRQ LSAFDISLRF 
THLFWFGDLN YRLDMDIQEI LNYISRREFE PLLRVDQLNL EREKHKVFLR FSEEEISFPP 
TYRYERGSRD TYAWHKQKPT GVRTNVPSWC DRILWKSYPE THIICNSYGC TDDIVTSDHS 
PVFGTFEVGV TSQFISKKGL SKTSDQAYIE FESIEAIVKT ASRTKFFIEF YSTCLEEYKK 
SFENDAQSSD NINFLKVQWS SRQLPTLKPI LADIEYLQDQ HLLLTVKSMD GYESYGECVV 
ALKSMIGSTA QQFLTFLSHR GEETGNIRGS MKVRVPTERL GTRERLYEWI SIDKDDTGAK 
SKVPSVSRGS QEHRSGSRKP ASTETSCPLS KLFEEPEKPP PTGRPPAPPR AVPREEPLNP 
RLKSEGTSEQ EGVAAPPPKN SFNNPAYYVL EGVPHQLLPL EPPSLARAPL PPATKNKVAI 
TVPAPQLGRH RTPRVGEGSS SDEDSGGTLP PPDFPPPPLP DSAIFLPPNL DPLSMPVVRG 
RSGGEARGPP PPKAHPRPPL PPGTSPASTF LGEVASGDDR SCSVLQMAKT LSEVDYAPGP 
GRSALLPNPL ELQPPRGPSD YGRPLSFPPP RIRESIQEDL AEEAPCPQGG RASGLGEAGM 
GAWLRAIGLE RYEEGLVHNG WDDLEFLSDI TEEDLEEAGV QDPAHKRLLL DTLQLSK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Inppl1

Associated with

Other Information

The mouse SHIP2 (Inppl1) gene: complementary DNA, genomic structure, promoter analysis, and gene expression in the embryo and adult mouse. PubMed ID: 10610720

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Examining the specificity of Src homology 3 domain -- ligand interactions with alkaline phosphatase fusion proteins. PubMed ID: 9126384

Inhibition of antigen-induced T cell response and antibody-induced NK cell cytotoxicity by NKG2A: association of NKG2A with SHP-1 and SHP-2 protein-tyrosine phosphatases. PubMed ID: 9485206

The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. PubMed ID: 10789675

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells. PubMed ID: 10958682

The lipid phosphatase SHIP2 controls insulin sensitivity. PubMed ID: 11343120

Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice. PubMed ID: 12145149

SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes. PubMed ID: 14744864

Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. PubMed ID: 15456754

SHIP family inositol phosphatases interact with and negatively regulate the Tec tyrosine kinase. PubMed ID: 15492005

SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling. PubMed ID: 15557176

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. PubMed ID: 15654325

The inositol phosphatase SHIP-2 down-regulates FcgammaR-mediated phagocytosis in murine macrophages independently of SHIP-1. PubMed ID: 16179375

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. PubMed ID: 21624956

Specific Eph receptor-cytoplasmic effector signaling mediated by SAM-SAM domain interactions. PubMed ID: 29749928