Genular: Defining Cellular Identity and Function

Details for: Ins1

Gene ID: 16333

Symbol: Ins1

Ensembl ID: ENSMUSG00000035804

Description: insulin I

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Copi-mediated anterograde transport
(R-MMU-6807878)
Er to golgi anterograde transport
(R-MMU-199977)
Insulin processing
(R-MMU-264876)
Insulin receptor recycling
(R-MMU-77387)
Insulin receptor signalling cascade
(R-MMU-74751)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irs activation
(R-MMU-74713)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Peptide hormone metabolism
(R-MMU-2980736)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Signal attenuation
(R-MMU-74749)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Synthesis, secretion, and deacylation of ghrelin
(R-MMU-422085)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Activation of protein kinase b activity
(GO:0032148)
Acute-phase response
(GO:0006953)
Alpha-beta t cell activation
(GO:0046631)
Carbohydrate metabolic process
(GO:0005975)
Collagen-containing extracellular matrix
(GO:0062023)
Cytosol
(GO:0005829)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid homeostasis
(GO:0055089)
Glucose homeostasis
(GO:0042593)
Glucose metabolic process
(GO:0006006)
Glucose transmembrane transport
(GO:1904659)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hormone activity
(GO:0005179)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor binding
(GO:0005159)
Insulin receptor binding
(GO:0005158)
Insulin receptor signaling pathway
(GO:0008286)
Negative regulation of acute inflammatory response
(GO:0002674)
Negative regulation of fatty acid metabolic process
(GO:0045922)
Negative regulation of feeding behavior
(GO:2000252)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glycogen catabolic process
(GO:0045818)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of nad(p)h oxidase activity
(GO:0033861)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Negative regulation of respiratory burst involved in inflammatory response
(GO:0060266)
Neuron projection maintenance
(GO:1990535)
Nitric oxide-cgmp-mediated signaling pathway
(GO:0038060)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dendritic spine maintenance
(GO:1902952)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of glycogen biosynthetic process
(GO:0045725)
Positive regulation of glycolytic process
(GO:0045821)
Positive regulation of insulin receptor signaling pathway
(GO:0046628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nitric oxide mediated signal transduction
(GO:0010750)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of protein secretion
(GO:0050714)
Positive regulation of respiratory burst
(GO:0060267)
Protease binding
(GO:0002020)
Receptor internalization
(GO:0031623)
Receptor ligand activity
(GO:0048018)
Regulation of cellular amino acid metabolic process
(GO:0006521)
Regulation of protein localization
(GO:0032880)
Regulation of protein localization to plasma membrane
(GO:1903076)
Regulation of protein secretion
(GO:0050708)
Regulation of transmembrane transporter activity
(GO:0022898)
Secretory granule lumen
(GO:0034774)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Vasodilation
(GO:0042311)
Wound healing
(GO:0042060)

Other Information

Proteins

Insulin-1

Genular Protein ID: 3857210865

Symbol: INS1_MOUSE

Name: Insulin-1

UniProtKB Accession Codes:

P01325 Q545I7 Q9D907

Database IDs:

Citations:

PubMed ID: 3104603

Title: Characterization of the two nonallelic genes encoding mouse preproinsulin.

PubMed ID: 3104603

DOI: 10.1007/bf02100639

PubMed ID: 2397023

Title: Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

PubMed ID: 2397023

DOI: 10.1677/jme.0.0050061

PubMed ID: 16682971

Title: Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus.

PubMed ID: 16682971

DOI: 10.1038/ng1796

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 5063718

Title: Amino acid sequence of the two insulins from mouse (Maus musculus).

PubMed ID: 5063718

DOI: 10.1515/bchm2.1972.353.1.451

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 108
Mass: 12160
Checksum: F63D9B7B896E0F88
Sequence:

MALLVHFLPL LALLALWEPK PTQAFVKQHL CGPHLVEALY LVCGERGFFY TPKSRREVED 
PQVEQLELGG SPGDLQTLAL EVARQKRGIV DQCCTSICSL YQLENYCN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ins1

Associated with

Other Information

Characterization of the two nonallelic genes encoding mouse preproinsulin. PubMed ID: 3104603

Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus. PubMed ID: 2397023

Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. PubMed ID: 16682971

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino acid sequence of the two insulins from mouse (Maus musculus). PubMed ID: 5063718

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079