Details for: Ins2

Gene ID: 16334

Symbol: Ins2

Ensembl ID: ENSMUSG00000000215

Description: insulin II

Associated with

  • Activation of protein kinase b activity
    (GO:0032148)
  • Acute-phase response
    (GO:0006953)
  • Alpha-beta t cell activation
    (GO:0046631)
  • Carbohydrate metabolic process
    (GO:0005975)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Endoplasmic reticulum lumen
    (GO:0005788)
  • Er overload response
    (GO:0006983)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fatty acid homeostasis
    (GO:0055089)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose metabolic process
    (GO:0006006)
  • Glucose transmembrane transport
    (GO:1904659)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Hormone activity
    (GO:0005179)
  • Identical protein binding
    (GO:0042802)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin processing
    (GO:0030070)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Lipid catabolic process
    (GO:0016042)
  • Myoblast fusion
    (GO:0007520)
  • Myotube differentiation
    (GO:0014902)
  • Negative regulation of acute inflammatory response
    (GO:0002674)
  • Negative regulation of fatty acid metabolic process
    (GO:0045922)
  • Negative regulation of feeding behavior
    (GO:2000252)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of glycogen catabolic process
    (GO:0045818)
  • Negative regulation of lipid catabolic process
    (GO:0050995)
  • Negative regulation of nad(p)h oxidase activity
    (GO:0033861)
  • Negative regulation of protein catabolic process
    (GO:0042177)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of proteolysis
    (GO:0045861)
  • Negative regulation of reactive oxygen species biosynthetic process
    (GO:1903427)
  • Negative regulation of respiratory burst involved in inflammatory response
    (GO:0060266)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron projection maintenance
    (GO:1990535)
  • Nitric oxide-cgmp-mediated signaling pathway
    (GO:0038060)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dendritic spine maintenance
    (GO:1902952)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of lipid kinase activity
    (GO:0090218)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of nitric oxide mediated signal transduction
    (GO:0010750)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein localization to nucleus
    (GO:1900182)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of protein secretion
    (GO:0050714)
  • Positive regulation of respiratory burst
    (GO:0060267)
  • Protease binding
    (GO:0002020)
  • Receptor internalization
    (GO:0031623)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cellular amino acid metabolic process
    (GO:0006521)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of phosphorylation
    (GO:0042325)
  • Regulation of protein binding
    (GO:0043393)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of protein localization to plasma membrane
    (GO:1903076)
  • Regulation of protein secretion
    (GO:0050708)
  • Regulation of transmembrane transporter activity
    (GO:0022898)
  • Secretory granule
    (GO:0030141)
  • Secretory granule lumen
    (GO:0034774)
  • Sno(s)rna-containing ribonucleoprotein complex
    (GO:0005732)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)
  • Vasodilation
    (GO:0042311)
  • Wound healing
    (GO:0042060)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 703319256

Symbol: INS2_MOUSE

Name: Insulin-2

UniProtKB Accession Codes:

P01326

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 5 ExpressionAtlas 1 GO 73 Gene3D 1 GeneTree 1 Genevisible 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 9 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3104603

Title: Characterization of the two nonallelic genes encoding mouse preproinsulin.

PubMed ID: 3104603

DOI: 10.1007/bf02100639

PubMed ID: 2397023

Title: Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus.

PubMed ID: 2397023

DOI: 10.1677/jme.0.0050061

PubMed ID: 5063718

Title: Amino acid sequence of the two insulins from mouse (Maus musculus).

PubMed ID: 5063718

DOI: 10.1515/bchm2.1972.353.1.451

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 110
  • Mass: 12364
  • Checksum: 3554C8803D24FDAD
  • Sequence:
    • MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED 
PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC SLYQLENYCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.