Details for: Irf1

Gene ID: 16362

Symbol: Irf1

Ensembl ID: ENSMUSG00000018899

Description: interferon regulatory factor 1

Associated with

  • Apoptotic process
    (GO:0006915)
  • Canonical nf-kappab signal transduction
    (GO:0007249)
  • Cd8-positive, alpha-beta t cell differentiation
    (GO:0043374)
  • Cellular response to interferon-beta
    (GO:0035458)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to peptide hormone stimulus
    (GO:0071375)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Defense response to virus
    (GO:0051607)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Immune system process
    (GO:0002376)
  • Innate immune response
    (GO:0045087)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of regulatory t cell differentiation
    (GO:0045590)
  • Negative regulation of t-helper 2 cell differentiation
    (GO:0045629)
  • Negative regulation of tyrosine phosphorylation of stat protein
    (GO:0042532)
  • Nucleus
    (GO:0005634)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of interferon-beta production
    (GO:0032728)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of natural killer cell differentiation
    (GO:0032825)
  • Positive regulation of t-helper 1 cell differentiation
    (GO:0045627)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of type i interferon production
    (GO:0032481)
  • Protein binding
    (GO:0005515)
  • Regulation of adaptive immune response
    (GO:0002819)
  • Regulation of cd8-positive, alpha-beta t cell proliferation
    (GO:2000564)
  • Regulation of cell cycle
    (GO:0051726)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of innate immune response
    (GO:0045088)
  • Regulation of myd88-dependent toll-like receptor signaling pathway
    (GO:0034124)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to growth hormone
    (GO:0060416)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Toll-like receptor 3 signaling pathway
    (GO:0034138)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Type ii interferon-mediated signaling pathway
    (GO:0060333)

Other Information

Genular Protein ID: 1624090012

Symbol: IRF1_MOUSE

Name: Interferon regulatory factor 1

UniProtKB Accession Codes:

P15314

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3409321

Title: Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-beta gene regulatory elements.

PubMed ID: 3409321

DOI: 10.1016/s0092-8674(88)91307-4

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10712599

Title: Degradation of transcription factor IRF-1 by the ubiquitin-proteasome pathway. The C-terminal region governs the protein stability.

PubMed ID: 10712599

DOI: 10.1046/j.1432-1327.2000.01163.x

PubMed ID: 11244049

Title: IRF family of transcription factors as regulators of host defense.

PubMed ID: 11244049

DOI: 10.1146/annurev.immunol.19.1.623

PubMed ID: 12387893

Title: PIAS3 induces SUMO-1 modification and transcriptional repression of IRF-1.

PubMed ID: 12387893

DOI: 10.1016/s0014-5793(02)03486-5

PubMed ID: 11846971

Title: Activities of IRF-1.

PubMed ID: 11846971

DOI: 10.1089/107999002753452610

PubMed ID: 11846974

Title: IRF-1 as a negative regulator of cell proliferation.

PubMed ID: 11846974

DOI: 10.1089/107999002753452647

PubMed ID: 16932750

Title: IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.

PubMed ID: 16932750

DOI: 10.1038/nri1900

PubMed ID: 17018642

Title: Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.

PubMed ID: 17018642

DOI: 10.1073/pnas.0607181103

PubMed ID: 18955028

Title: Ubc9-mediated sumoylation leads to transcriptional repression of IRF-1.

PubMed ID: 18955028

DOI: 10.1016/j.bbrc.2008.10.092

PubMed ID: 18641303

Title: IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.

PubMed ID: 18641303

DOI: 10.4049/jimmunol.181.3.1673

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 20308629

Title: IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.

PubMed ID: 20308629

DOI: 10.4049/jimmunol.0902264

PubMed ID: 21909274

Title: Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection.

PubMed ID: 21909274

DOI: 10.1371/journal.ppat.1002230

PubMed ID: 25774715

Title: The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.

PubMed ID: 25774715

DOI: 10.1038/ni.3118

PubMed ID: 27693356

Title: IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11-NLRP3 inflammasomes.

PubMed ID: 27693356

DOI: 10.1016/j.cell.2016.09.012

PubMed ID: 29321274

Title: IRF1 is a transcriptional regulator of ZBP1 promoting NLRP3 inflammasome activation and cell death during influenza virus infection.

PubMed ID: 29321274

DOI: 10.4049/jimmunol.1701538

PubMed ID: 30635240

Title: The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons.

PubMed ID: 30635240

DOI: 10.1016/j.immuni.2018.11.017

PubMed ID: 9422515

Title: Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.

PubMed ID: 9422515

DOI: 10.1038/34224

Sequence Information:

  • Length: 329
  • Mass: 37319
  • Checksum: 0E5DD23C0D977B34
  • Sequence:
    • MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI 
HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTRNQR 
KERKSKSSRD TKSKTKRKLC GDVSPDTFSD GLSSSTLPDD HSSYTTQGYL GQDLDMERDI 
TPALSPCVVS SSLSEWHMQM DIIPDSTTDL YNLQVSPMPS TSEAATDEDE EGKIAEDLMK 
LFEQSEWQPT HIDGKGYLLN EPGTQLSSVY GDFSCKEEPE IDSPRGDIGI GIQHVFTEMK 
NMDSIMWMDS LLGNSVRLPP SIQAIPCAP

Genular Protein ID: 2045221271

Symbol: Q3U5M1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U5M1

Database IDs:

AGR 1 ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneTree 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 1 PROSITE 3 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 304
  • Mass: 34627
  • Checksum: 9860ECF9C488BD59
  • Sequence:
    • MPITRMRMRP WLEMQINSNQ IPGLIWINKE EMIFQIPWKH AAKHGWDINK DACLFRSWAI 
HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN KGSSAVRVYR MLPPLTRNQR 
KERKSKSSRD TKSKTKRKLC GDVSPDTFSD GLSSSTLPDD HSSYTTQGYL GQDLDMERDI 
TPALSPCVVS SSLSEWHMQM DIIPDSTTDL YNLQVSPMPS TSEAATDEDE EGKIAEDLMK 
LFEQSEWQPT HIDGKGYLLN EPGTQLSSVY GDFSCKEEPE IDSPRGNLLM GVFCWLSAWA 
SAEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.