Details for: Irf4

Gene ID: 16364

Symbol: Irf4

Ensembl ID: ENSMUSG00000021356

Description: interferon regulatory factor 4

Associated with

  • Chromatin remodeling
    (GO:0006338)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cytosol
    (GO:0005829)
  • Defense response to protozoan
    (GO:0042832)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Immune system process
    (GO:0002376)
  • Myeloid dendritic cell differentiation
    (GO:0043011)
  • Negative regulation of toll-like receptor signaling pathway
    (GO:0034122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleosome
    (GO:0000786)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of dna binding
    (GO:0043388)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T-helper 17 cell lineage commitment
    (GO:0072540)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription coactivator activity
    (GO:0003713)

Other Information

Genular Protein ID: 3026975178

Symbol: IRF4_MOUSE

Name: Interferon regulatory factor 4

UniProtKB Accession Codes:

Q64287 Q60802

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CORUM 1 CTD 1 DIP 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 26 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7797077

Title: Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

PubMed ID: 7797077

DOI: 10.1101/gad.9.11.1377

PubMed ID: 7541907

Title: Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).

PubMed ID: 7541907

DOI: 10.1093/nar/23.12.2127

PubMed ID: 20697158

Title: Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice.

PubMed ID: 20697158

DOI: 10.1172/jci42856

PubMed ID: 22992524

Title: Compensatory dendritic cell development mediated by BATF-IRF interactions.

PubMed ID: 22992524

DOI: 10.1038/nature11531

PubMed ID: 22992523

Title: BATF-JUN is critical for IRF4-mediated transcription in T cells.

PubMed ID: 22992523

DOI: 10.1038/nature11530

PubMed ID: 22983707

Title: A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes.

PubMed ID: 22983707

DOI: 10.1126/science.1228309

PubMed ID: 26098997

Title: The receptor NLRP3 is a transcriptional regulator of TH2 differentiation.

PubMed ID: 26098997

DOI: 10.1038/ni.3202

Sequence Information:

  • Length: 450
  • Mass: 51577
  • Checksum: 5FD94CA6C453869C
  • Sequence:
    • MNLETGSRGS EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSVF RIPWKHAGKQ 
DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD 
PYKVYRIVPE GAKKGAKQLT LDDTQMAMGH PYPMTAPYGS LPAQQVHNYM MPPHDRSWRD 
YAPDQSHPEI PYQCPVTFGP RGHHWQGPSC ENGCQVTGTF YACAPPESQA PGIPIEPSIR 
SAEALALSDC RLHICLYYRD ILVKELTTTS PEGCRISHGH TYDVSNLDQV LFPYPDDNGQ 
RKNIEKLLSH LERGLVLWMA PDGLYAKRLC QSRIYWDGPL ALCSDRPNKL ERDQTCKLFD 
TQQFLSELQV FAHHGRPAPR FQVTLCFGEE FPDPQRQRKL ITAHVEPLLA RQLYYFAQQN 
TGHFLRGYEL PEHVTTPDYH RSLRHSSIQE

Genular Protein ID: 3626167118

Symbol: Q5SUZ5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5SUZ5

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 EPD 1 ExpressionAtlas 1 GO 5 Gene3D 2 HOGENOM 1 InterPro 7 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 449
  • Mass: 51449
  • Checksum: C4E4A0DC04AA8A52
  • Sequence:
    • MNLETGSRGS EFGMSAVSCG NGKLRQWLID QIDSGKYPGL VWENEEKSVF RIPWKHAGKQ 
DYNREEDAAL FKAWALFKGK FREGIDKPDP PTWKTRLRCA LNKSNDFEEL VERSQLDISD 
PYKVYRIVPE GAKKGAKQLT LDDTQMAMGH PYPMTAPYGS LPAQVHNYMM PPHDRSWRDY 
APDQSHPEIP YQCPVTFGPR GHHWQGPSCE NGCQVTGTFY ACAPPESQAP GIPIEPSIRS 
AEALALSDCR LHICLYYRDI LVKELTTTSP EGCRISHGHT YDVSNLDQVL FPYPDDNGQR 
KNIEKLLSHL ERGLVLWMAP DGLYAKRLCQ SRIYWDGPLA LCSDRPNKLE RDQTCKLFDT 
QQFLSELQVF AHHGRPAPRF QVTLCFGEEF PDPQRQRKLI TAHVEPLLAR QLYYFAQQNT 
GHFLRGYELP EHVTTPDYHR SLRHSSIQE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.