Details for: Acod1

Gene ID: 16365

Symbol: Acod1

Ensembl ID: ENSMUSG00000022126

Description: aconitate decarboxylase 1

Associated with

  • Aconitate decarboxylase activity
    (GO:0047613)
  • Cellular response to interferon-beta
    (GO:0035458)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to molecule of bacterial origin
    (GO:0071219)
  • Cellular response to progesterone stimulus
    (GO:0071393)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Cellular response to type ii interferon
    (GO:0071346)
  • Defense response
    (GO:0006952)
  • Defense response to virus
    (GO:0051607)
  • Embryo implantation
    (GO:0007566)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Lyase activity
    (GO:0016829)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of innate immune response
    (GO:0045824)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of toll-like receptor 2 signaling pathway
    (GO:0034136)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Negative regulation of type i interferon production
    (GO:0032480)
  • Positive regulation of antimicrobial humoral response
    (GO:0002760)
  • Positive regulation of reactive oxygen species metabolic process
    (GO:2000379)
  • Protein homodimerization activity
    (GO:0042803)
  • Response to bacterium
    (GO:0009617)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Tolerance induction to lipopolysaccharide
    (GO:0072573)

Other Information

Genular Protein ID: 4128461222

Symbol: IRG1_MOUSE

Name: Cis-aconitate decarboxylase

UniProtKB Accession Codes:

P54987 Q3TAA1 Q3U8E8 Q8CBA6

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 EC 1 EMBL 8 GO 25 Gene3D 2 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 2 PIR 1 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7721348

Title: Cloning and analysis of gene regulation of a novel LPS-inducible cDNA.

PubMed ID: 7721348

DOI: 10.1007/bf00172150

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14500577

Title: Immune-responsive gene 1 is a novel target of progesterone receptor and plays a critical role during implantation in the mouse.

PubMed ID: 14500577

DOI: 10.1210/en.2003-0585

PubMed ID: 19014335

Title: The proinflammatory cytokine-induced IRG1 protein associates with mitochondria.

PubMed ID: 19014335

DOI: 10.1089/jir.2008.0013

PubMed ID: 23609450

Title: Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through ROS.

PubMed ID: 23609450

DOI: 10.1074/jbc.m113.454538

PubMed ID: 23610393

Title: Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.

PubMed ID: 23610393

DOI: 10.1073/pnas.1218599110

PubMed ID: 30635240

Title: The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons.

PubMed ID: 30635240

DOI: 10.1016/j.immuni.2018.11.017

PubMed ID: 35662396

Title: Itaconate is a lysosomal inducer that promotes antibacterial innate immunity.

PubMed ID: 35662396

DOI: 10.1016/j.molcel.2022.05.009

PubMed ID: 31548418

Title: Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis.

PubMed ID: 31548418

DOI: 10.1073/pnas.1908770116

PubMed ID: 33259501

Title: The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation.

PubMed ID: 33259501

DOI: 10.1371/journal.pone.0242383

Sequence Information:

  • Length: 488
  • Mass: 53758
  • Checksum: 0F573147307DE684
  • Sequence:
    • MMLKSVTESF AGMIHGLKVN HLTDGIIRRS KRMILDSLGV GFLGTGTEVF HKVTQYSKIY 
SSNTSSTVWG RPDFRLPPTY AAFVNGVAVH SMDFDDTWHP ATHPSGAVLP VLTALSEALP 
QIPKFSGLDL LLAFNVGIEV QGRLMHFSKE AKDIPKRFHP PSVVGTLGSA AAASKFLGLS 
LTKCREALAI AVSHAGAPIA NAATQTKPLH IGNAAKHGME ATFLAMLGLQ GNKQILDLGS 
GFGAFYANYS PEDLPSLDSH IWLLDQQDVA FKSFPAHLAT HWVADAAAAV RKHLVTPERA 
LFPADHIERI VLRIPDVQYV NRPFPDSEHE ARHSFQYVAC ASLLDGSITV PSFHSQQVNR 
PQVRELLKKV KLEHPPDNPP SFDTLYCEIS ITLKDGTTFT ERSDTFYGHW RKPLSQEDLR 
NKFRANASKM LCRDTVESLI TVVEKLEDLE DCSVLTRLLK GPSVQDEASK LSSMSSFDHT 
TLPRFTNI

Genular Protein ID: 1271849946

Symbol: A0A0R4J027_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J027

Database IDs:

AGR 1 ARBA 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 EPD 2 Ensembl 2 GO 5 Gene3D 2 GeneTree 1 InterPro 6 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 488
  • Mass: 53746
  • Checksum: 0FE1EF48C3721A88
  • Sequence:
    • MMLKSVTESF AGMIHGLKVN HLTDGIIRRS KRMILDSLGV GFLGTGTEVF HKVTQYSKIY 
SSNTSSTVWG RPDFRLPPTY AAFVNGVAVH SMDFDDTWHP ATHPSGAVLP VLTALSEALP 
QTPKFSGLDL LLAFNVGIEV QGRLMHFSKE AKDIPKRFHP PSVVGTLGSA AAASKFLGLS 
LTKCREALAI AVSHAGAPIA NAATQTKPLH IGNAAKHGME ATFLAMLGLQ GNKQILDLGS 
GFGAFYANYS PEDLPSLDSH IWLLDQQDVA FKSFPAHLAT HWVADAAAAV RKHLVTPERA 
LFPADHIERI VLRIPDVQYV NRPFPDSEHE ARHSFQYVAC ASLLDGSITV PSFHSQQVNR 
PQVRELLKKV KLEHPPDNPP SFDTLYCEIS ITLKDGTTFT ERSDTFYGHW RKPLSQEDLR 
NKFRANASKM LCRDTVESLI TVVEKLEDLE DCSVLTRLLK GPSVQDEASK LSSMSSFDHT 
TLPRFTNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.