Details for: Irx1

Gene ID: 16371

Symbol: Irx1

Ensembl ID: ENSMUSG00000060969

Description: Iroquois homeobox 1

Associated with

  • Cell development
    (GO:0048468)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Metanephros development
    (GO:0001656)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Positive regulation of gene expression
    (GO:0010628)
  • Proximal/distal pattern formation involved in metanephric nephron development
    (GO:0072272)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to organic cyclic compound
    (GO:0014070)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Specification of loop of henle identity
    (GO:0072086)

Other Information

Genular Protein ID: 222346882

Symbol: IRX1_MOUSE

Name: Iroquois-class homeodomain protein IRX-1

UniProtKB Accession Codes:

P81068 G5E8H6 O55120 Q3UZB9 Q9JLL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10926765

Title: Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.

PubMed ID: 10926765

DOI: 10.1006/dbio.2000.9801

PubMed ID: 10704856

Title: Expression of two novel mouse Iroquois-class homeobox genes during neurogenesis.

PubMed ID: 10704856

DOI: 10.1016/s0925-4773(99)00263-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9486539

Title: Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.

PubMed ID: 9486539

DOI: 10.1016/s0925-4773(97)00165-2

PubMed ID: 17875669

Title: The prepattern transcription factor Irx3 directs nephron segment identity.

PubMed ID: 17875669

DOI: 10.1101/gad.450707

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 480
  • Mass: 50169
  • Checksum: 38D141E4C127A6C1
  • Sequence:
    • MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGTAELGA GAGAAAVTSV 
LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTTPAYYPY 
GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN 
ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DQIDERDGDQ 
SNEDEEDKAE APRARVAPPA SARDQSSPLS AAETLKSQDS PLGLVKEVSE PGSTRLLSPG 
AAAVGLQGAP HSKPKIWSLA ETATSPDGAP KASPPPPSSH ASAHGPPSGS PLQHPAFLPS 
HGLYTCHIGK FSNWTNGAFL AQGSLLNMRS FLGVSAPHAA PHGPHLTAPP PPQPPVQVAT 
GVLHGEKASA RSSPALPERD LVTRPDSPPQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.