Details for: Irx2

Gene ID: 16372

Symbol: Irx2

Ensembl ID: ENSMUSG00000001504

Description: Iroquois homeobox 2

Associated with

  • Cell development
    (GO:0048468)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Metanephros development
    (GO:0001656)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Proximal/distal pattern formation involved in metanephric nephron development
    (GO:0072272)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Specification of loop of henle identity
    (GO:0072086)

Other Information

Genular Protein ID: 3693007246

Symbol: IRX2_MOUSE

Name: Iroquois-class homeodomain protein IRX-2

UniProtKB Accession Codes:

P81066 O55121 Q3UFG3 Q9ERN1 Q9JLL4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10926765

Title: Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.

PubMed ID: 10926765

DOI: 10.1006/dbio.2000.9801

PubMed ID: 10704856

Title: Expression of two novel mouse Iroquois-class homeobox genes during neurogenesis.

PubMed ID: 10704856

DOI: 10.1016/s0925-4773(99)00263-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9486539

Title: Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.

PubMed ID: 9486539

DOI: 10.1016/s0925-4773(97)00165-2

PubMed ID: 17875669

Title: The prepattern transcription factor Irx3 directs nephron segment identity.

PubMed ID: 17875669

DOI: 10.1101/gad.450707

Sequence Information:

  • Length: 474
  • Mass: 49484
  • Checksum: 04E39C42E717F98B
  • Sequence:
    • MSYPQGYLYQ APGSLALYSC PAYGASALAA PRSEELARSA SGSAFSPYPG SAAFTAQAAT 
GFGSPLQYSA DAAAAAAAGF PSYVGSPYDT HTTGMTGAIS YHPYGSAAYP YQLNDPAYRK 
NATRDATATL KAWLNEHRKN PYPTKGEKIM LAIITKMTLT QVSTWFANAR RRLKKENKMT 
WAPRNKSEDE DEDEGDASRS KEESSDKAQD GTETSAEDEG ISLHVDSLTD HSCSAESDGE 
KLPCRAGDAL CESGSECKDK FEDLEDEEDE EDECERDLAP PKPVTSSPLT GVEAPLLSPA 
PEAAPRGGSG GKTPLGSRTS PGAPPPASKP KLWSLAEIAT SDLKQPSLGP GCGPPGLPAA 
AAPASTGAPP GGSPYSASPL LGRHLYYTSP FYGNYTNYGN LNAALQGQGL LRYNTAASSP 
GETLHAMPKA ASDTGKAGSH SLESHYRPPG GGYEPKKDTS EGCAVVGAGV QTYL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.