Details for: Irx3

Gene ID: 16373

Symbol: Irx3

Ensembl ID: ENSMUSG00000031734

Description: Iroquois related homeobox 3

Associated with

  • Atrioventricular bundle cell differentiation
    (GO:0003167)
  • Axon
    (GO:0030424)
  • Cell development
    (GO:0048468)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Energy homeostasis
    (GO:0097009)
  • His-purkinje system cell differentiation
    (GO:0060932)
  • Kidney development
    (GO:0001822)
  • Mesoderm development
    (GO:0007498)
  • Metanephros development
    (GO:0001656)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nucleus
    (GO:0005634)
  • Positive regulation of gap junction assembly
    (GO:1903598)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Proximal/distal pattern formation involved in nephron development
    (GO:0072047)
  • Purkinje myocyte development
    (GO:0003165)
  • Regulation of cell communication by electrical coupling involved in cardiac conduction
    (GO:1901844)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Specification of loop of henle identity
    (GO:0072086)

Other Information

Genular Protein ID: 3592675565

Symbol: IRX3_MOUSE

Name: Iroquois-class homeodomain protein IRX-3

UniProtKB Accession Codes:

P81067 Q3UPZ3 Q5U3K8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 DNASU 1 EMBL 4 Ensembl 2 GO 26 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9486539

Title: Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.

PubMed ID: 9486539

DOI: 10.1016/s0925-4773(97)00165-2

PubMed ID: 10926765

Title: Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.

PubMed ID: 10926765

DOI: 10.1006/dbio.2000.9801

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427753

Title: Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification.

PubMed ID: 9427753

DOI: 10.1093/emboj/17.1.191

PubMed ID: 10830170

Title: A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube.

PubMed ID: 10830170

DOI: 10.1016/s0092-8674(00)80853-3

PubMed ID: 10704856

Title: Expression of two novel mouse Iroquois-class homeobox genes during neurogenesis.

PubMed ID: 10704856

DOI: 10.1016/s0925-4773(99)00263-4

PubMed ID: 15201216

Title: Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors.

PubMed ID: 15201216

DOI: 10.1242/dev.01179

PubMed ID: 17875669

Title: The prepattern transcription factor Irx3 directs nephron segment identity.

PubMed ID: 17875669

DOI: 10.1101/gad.450707

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24646999

Title: Obesity-associated variants within FTO form long-range functional connections with IRX3.

PubMed ID: 24646999

DOI: 10.1038/nature13138

Sequence Information:

  • Length: 507
  • Mass: 52693
  • Checksum: 04FD67E8F5C29AB6
  • Sequence:
    • MSFPQLGYQY IRPLYPPERP GAAGGGGGGS SAGGRSGPGA GASELAASGS LSNVLSSVYG 
APYAAAAAAA AAAQGYGAFL PYATELPIFP QLGAQYELKD SPGVQHPATA AAFPHPHPAF 
YPYGQYQFGD PSRPKNATRE STSTLKAWLN EHRKNPYPTK GEKIMLAIIT KMTLTQVSTW 
FANARRRLKK ENKMTWAPRS RTDEEGNAYG SEREEEDEEE DEEESKRELE MEEEELAGEE 
EDTGGEGLAD DDEDEEIDLE NLDSAAAGSE LTLAGAAHRN GDFGLGPISD CKTSDSDDSS 
EGLEDRPLSV LSLAPPPPPV ARAPASPPSP PSSLDPCAPA PAPSSALQKP KIWSLAETAT 
SPDNPRRSPP GAGGSPPGAA VAPPTLQLSP AAAAAAAAAH RLVSAPLGKF PAWTNRPFPG 
PPAGPRPHPL SMLGSAPQHL LGLPGAAGHP AAAAAAYARP AEPESGTDRC SALEVEKKLL 
KTAFQPVPRR PQNHLDAALV LSALSSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.