Details for: DCTN1

Gene ID: 1639

Symbol: DCTN1

Ensembl ID: ENSG00000204843

Description: dynactin subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.59
    Marker Score: 392
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.51
    Marker Score: 1692
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.44
    Marker Score: 14875
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.37
    Marker Score: 1927
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.37
    Marker Score: 1472
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.35
    Marker Score: 1429
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1644
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.31
    Marker Score: 1884
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.3
    Marker Score: 374
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.27
    Marker Score: 2898
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.25
    Marker Score: 10764
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.25
    Marker Score: 7422
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.23
    Marker Score: 1905
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.21
    Marker Score: 1006.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.19
    Marker Score: 1097
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.16
    Marker Score: 389
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71127
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.12
    Marker Score: 523
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.11
    Marker Score: 11197.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.11
    Marker Score: 10560
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.11
    Marker Score: 3015
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.09
    Marker Score: 438
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.06
    Marker Score: 6903.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.02
    Marker Score: 9551
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1
    Marker Score: 7451
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1
    Marker Score: 517
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71664
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47888.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30385
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.98
    Marker Score: 539
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.97
    Marker Score: 11290
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.97
    Marker Score: 1426
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.95
    Marker Score: 3870.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.95
    Marker Score: 398
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.94
    Marker Score: 629
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2387
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.93
    Marker Score: 3613
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.92
    Marker Score: 34771
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.91
    Marker Score: 1857
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.91
    Marker Score: 3808
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.91
    Marker Score: 617
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14188
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.9
    Marker Score: 5759.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.9
    Marker Score: 554
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.9
    Marker Score: 635
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.9
    Marker Score: 845.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2685
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.9
    Marker Score: 1190
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.89
    Marker Score: 2255
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.89
    Marker Score: 1482
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.89
    Marker Score: 3278
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.89
    Marker Score: 645
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.88
    Marker Score: 328
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.88
    Marker Score: 261
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.87
    Marker Score: 922
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.87
    Marker Score: 32129
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.87
    Marker Score: 246
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.86
    Marker Score: 1532
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5217
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.86
    Marker Score: 7547
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.85
    Marker Score: 410
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.85
    Marker Score: 1774
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.84
    Marker Score: 395
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.84
    Marker Score: 868
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.84
    Marker Score: 16620
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.83
    Marker Score: 1008
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.83
    Marker Score: 206
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.83
    Marker Score: 996
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4688
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.82
    Marker Score: 830
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9140
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.8
    Marker Score: 2767
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8
    Marker Score: 535
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8
    Marker Score: 3144
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.8
    Marker Score: 256
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.8
    Marker Score: 1550
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.8
    Marker Score: 472
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.79
    Marker Score: 1346
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.79
    Marker Score: 795
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.78
    Marker Score: 1275
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.78
    Marker Score: 823
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.78
    Marker Score: 212
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.78
    Marker Score: 816.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.77
    Marker Score: 223
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.77
    Marker Score: 181
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.77
    Marker Score: 26667
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.77
    Marker Score: 409
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.76
    Marker Score: 11431
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.76
    Marker Score: 1436
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.76
    Marker Score: 669
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.76
    Marker Score: 3148
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.76
    Marker Score: 5812.5
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.76
    Marker Score: 3971
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.75
    Marker Score: 650

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Other Information

## Summary The DCTN1 gene encodes for the dynactin subunit 1, a cytoskeletal protein that plays a crucial role in the dynamic properties of plasma membranes and the assembly of cellular structures. It is highly expressed in various cell types, including oocyte, peripheral nervous system neuron, dopaminergic neuron, chromaffin cell, Leydig cell, primordial germ cell, oogonial cell, and male germ cell. ## Key characteristics * It is a large protein with a molecular weight of approximately 130 kDa. * It is a member of the dynactin family of cytoskeletal proteins. * It is involved in various cellular processes, including cell cycle regulation, organelle biogenesis, and protein trafficking. * It is also involved in the assembly of microfilaments and stress responses. ## Pathways and functions * **Adaptive immune system:** DCTN1 is expressed in oocyte, dendritic cells, macrophages, and dendritic cells, where it is involved in the regulation of adaptive immune responses. * **Anchoring of the basal body to the plasma membrane:** DCTN1 is a key component of the plasma membrane anchoring complex, which is responsible for the stability and function of the basal body. * **Asparagine n-linked glycosylation:** DCTN1 is a target for asparagine-linked glycosylation, which is a post-translational modification that can regulate protein-protein interactions and cell signaling. * **Cell cycle:** DCTN1 is expressed in cells during the G1 and G2 phases of the cell cycle, where it is involved in cell cycle regulation and the maintenance of cell cycle integrity. * **Mitotic g2-g2/m phases:** DCTN1 is also expressed in cells during the mitotic g2-g2/m phases, where it is involved in the regulation of cell cycle progression and cell division. * **Organelle biogenesis and maintenance:** DCTN1 is involved in the biogenesis and maintenance of various cellular organelles, including mitochondria and lysosomes. * **Post-translational protein modification:** DCTN1 is also involved in the post-translational modification of proteins, where it is phosphorylated by various kinases. ## Clinical significance Mutations in the DCTN1 gene have been linked to several human diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. These diseases are characterized by abnormal cell behavior and proliferation, which is often associated with dysregulation of the dynactin family of cytoskeletal proteins. Therefore, targeting DCTN1 signaling or expression has emerged as a potential therapeutic strategy for these diseases.

Genular Protein ID: 3187349859

Symbol: DCTN1_HUMAN

Name: Dynactin subunit 1

UniProtKB Accession Codes:

Q14203 A8MY36 B4DM45 E9PFS5 E9PGE1 G5E9H4 O95296 Q6IQ37 Q9BRM9 Q9UIU1 Q9UIU2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CORUM 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 33 EMDB 3 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 9 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 13 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9799602

Title: Human DCTN1: genomic structure and evaluation as a candidate for Alstrom syndrome.

PubMed ID: 9799602

DOI: 10.1006/geno.1998.5542

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8838327

Title: Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization.

PubMed ID: 8838327

DOI: 10.1006/geno.1996.0068

PubMed ID: 8856662

Title: Functionally distinct isoforms of dynactin are expressed in human neurons.

PubMed ID: 8856662

DOI: 10.1091/mbc.7.8.1167

PubMed ID: 9805007

Title: The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy.

PubMed ID: 9805007

DOI: 10.1016/s0167-4781(98)00195-x

PubMed ID: 14514668

Title: Characterization of functional domains of human EB1 family proteins.

PubMed ID: 14514668

DOI: 10.1074/jbc.m306194200

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17532294

Title: FBXL5 interacts with p150Glued and regulates its ubiquitination.

PubMed ID: 17532294

DOI: 10.1016/j.bbrc.2007.05.068

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19935774

Title: The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.

PubMed ID: 19935774

DOI: 10.1038/cr.2009.130

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20682791

Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.

PubMed ID: 20682791

DOI: 10.1074/jbc.m110.154120

PubMed ID: 20719959

Title: Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.

PubMed ID: 20719959

DOI: 10.1091/mbc.e10-05-0430

PubMed ID: 20978158

Title: A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.

PubMed ID: 20978158

DOI: 10.1158/1535-7163.mct-10-0730

PubMed ID: 20679239

Title: Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.

PubMed ID: 20679239

DOI: 10.1073/pnas.1006615107

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22159412

Title: Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.

PubMed ID: 22159412

DOI: 10.1242/jcs.085407

PubMed ID: 22261744

Title: Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.

PubMed ID: 22261744

DOI: 10.1007/s00018-011-0913-1

PubMed ID: 22797915

Title: The centriolar satellite protein Cep131 is important for genome stability.

PubMed ID: 22797915

DOI: 10.1242/jcs.104059

PubMed ID: 22327364

Title: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.

PubMed ID: 22327364

DOI: 10.1038/ncb2440

PubMed ID: 23386061

Title: Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.

PubMed ID: 23386061

DOI: 10.1038/emboj.2013.3

PubMed ID: 23509069

Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.

PubMed ID: 23509069

DOI: 10.1083/jcb.201207050

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23985322

Title: Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.

PubMed ID: 23985322

DOI: 10.1091/mbc.e13-03-0137

PubMed ID: 24867236

Title: Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation.

PubMed ID: 24867236

DOI: 10.1111/boc.201300087

PubMed ID: 25189619

Title: HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.

PubMed ID: 25189619

DOI: 10.1242/jcs.141978

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25774020

Title: Cell cycle-dependent localization of dynactin subunit p150 glued at centrosome.

PubMed ID: 25774020

DOI: 10.1002/jcb.25160

PubMed ID: 26968983

Title: Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility.

PubMed ID: 26968983

DOI: 10.15252/embj.201593071

PubMed ID: 28394342

Title: Regulation of spindle integrity and mitotic fidelity by BCCIP.

PubMed ID: 28394342

DOI: 10.1038/onc.2017.92

PubMed ID: 16109370

Title: Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.

PubMed ID: 16109370

DOI: 10.1016/j.molcel.2005.06.034

PubMed ID: 16949363

Title: Key interaction modes of dynamic +TIP networks.

PubMed ID: 16949363

DOI: 10.1016/j.molcel.2006.07.013

PubMed ID: 17828277

Title: Structure-function relationship of CAP-Gly domains.

PubMed ID: 17828277

DOI: 10.1038/nsmb1291

PubMed ID: 17828275

Title: CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.

PubMed ID: 17828275

DOI: 10.1038/nsmb1299

PubMed ID: 12627231

Title: Mutant dynactin in motor neuron disease.

PubMed ID: 12627231

DOI: 10.1038/ng1123

PubMed ID: 15326253

Title: Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS.

PubMed ID: 15326253

DOI: 10.1212/01.wnl.0000134608.83927.b1

PubMed ID: 16240349

Title: Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD.

PubMed ID: 16240349

DOI: 10.1002/ana.20631

PubMed ID: 16505168

Title: A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation.

PubMed ID: 16505168

DOI: 10.1083/jcb.200511068

PubMed ID: 17824900

Title: The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.

PubMed ID: 17824900

DOI: 10.1111/j.1600-0404.2007.00884.x

PubMed ID: 19136952

Title: DCTN1 mutations in Perry syndrome.

PubMed ID: 19136952

DOI: 10.1038/ng.293

PubMed ID: 19506225

Title: Characterization of DCTN1 genetic variability in neurodegeneration.

PubMed ID: 19506225

DOI: 10.1212/wnl.0b013e3181a92c4c

PubMed ID: 19279216

Title: Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.

PubMed ID: 19279216

DOI: 10.1073/pnas.0810828106

PubMed ID: 22777741

Title: Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).

PubMed ID: 22777741

DOI: 10.1007/s00441-012-1463-z

PubMed ID: 23874158

Title: Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.

PubMed ID: 23874158

DOI: 10.1371/journal.pbio.1001611

PubMed ID: 24627108

Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.

PubMed ID: 24627108

DOI: 10.1007/s00415-014-7289-8

PubMed ID: 24676999

Title: A Novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy.

PubMed ID: 24676999

DOI: 10.1002/mds.25833

PubMed ID: 25185702

Title: Dynactin functions as both a dynamic tether and brake during dynein-driven motility.

PubMed ID: 25185702

DOI: 10.1038/ncomms5807

PubMed ID: 24881494

Title: Three families with Perry syndrome from distinct parts of the world.

PubMed ID: 24881494

DOI: 10.1016/j.parkreldis.2014.05.004

PubMed ID: 26972003

Title: Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons.

PubMed ID: 26972003

DOI: 10.1016/j.celrep.2016.02.046

Sequence Information:

  • Length: 1278
  • Mass: 141695
  • Checksum: 6DCEA5E67856E4BC
  • Sequence:
    • MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV 
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE 
GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS 
SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE 
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT 
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL 
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE 
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE 
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA 
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG 
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL 
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL 
TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI 
ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV 
LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM 
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK 
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK EFEETMDALQ 
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS 
VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG 
SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE 
KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH 
RLVLTQEQLH QLHSRLIS

Genular Protein ID: 1591215602

Symbol: Q6MZZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZZ3

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 2 PharmGKB 1 RefSeq 2 SAM 2 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1278
  • Mass: 141551
  • Checksum: F2EC8478EF8899FE
  • Sequence:
    • MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV 
ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE 
GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS 
SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE 
DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT 
ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL 
KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE 
STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE 
TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA 
SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMGVAQ ANRHMSLLTA FMPDSFLRPG 
GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL 
SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL 
TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI 
ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV 
LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM 
NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK 
IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK GFEETMDALQ 
ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS 
VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG 
SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE 
KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH 
RLVLTQEQLH QLHSRLIS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.