Details for: DCTN1
Associated with
Other Information
Genular Protein ID: 3187349859
Symbol: DCTN1_HUMAN
Name: Dynactin subunit 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9799602
Title: Human DCTN1: genomic structure and evaluation as a candidate for Alstrom syndrome.
PubMed ID: 9799602
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8838327
Title: Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization.
PubMed ID: 8838327
PubMed ID: 8856662
Title: Functionally distinct isoforms of dynactin are expressed in human neurons.
PubMed ID: 8856662
DOI: 10.1091/mbc.7.8.1167
PubMed ID: 9805007
Title: The genomic structure of DCTN1, a candidate gene for limb-girdle muscular dystrophy.
PubMed ID: 9805007
PubMed ID: 14514668
Title: Characterization of functional domains of human EB1 family proteins.
PubMed ID: 14514668
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17532294
Title: FBXL5 interacts with p150Glued and regulates its ubiquitination.
PubMed ID: 17532294
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19935774
Title: The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport.
PubMed ID: 19935774
DOI: 10.1038/cr.2009.130
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20682791
Title: A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.
PubMed ID: 20682791
PubMed ID: 20719959
Title: Par6 alpha interacts with the dynactin subunit p150 Glued and is a critical regulator of centrosomal protein recruitment.
PubMed ID: 20719959
PubMed ID: 20978158
Title: A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells.
PubMed ID: 20978158
PubMed ID: 20679239
Title: Polo-like kinase 1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase.
PubMed ID: 20679239
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22159412
Title: Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.
PubMed ID: 22159412
DOI: 10.1242/jcs.085407
PubMed ID: 22261744
Title: Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments.
PubMed ID: 22261744
PubMed ID: 22797915
Title: The centriolar satellite protein Cep131 is important for genome stability.
PubMed ID: 22797915
DOI: 10.1242/jcs.104059
PubMed ID: 22327364
Title: Chromosome- and spindle-pole-derived signals generate an intrinsic code for spindle position and orientation.
PubMed ID: 22327364
DOI: 10.1038/ncb2440
PubMed ID: 23386061
Title: Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
PubMed ID: 23386061
DOI: 10.1038/emboj.2013.3
PubMed ID: 23509069
Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
PubMed ID: 23509069
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23985322
Title: Ste20-like protein kinase SLK (LOSK) regulates microtubule organization by targeting dynactin to the centrosome.
PubMed ID: 23985322
PubMed ID: 24867236
Title: Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation.
PubMed ID: 24867236
PubMed ID: 25189619
Title: HPS6 interacts with dynactin p150Glued to mediate retrograde trafficking and maturation of lysosomes.
PubMed ID: 25189619
DOI: 10.1242/jcs.141978
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25774020
Title: Cell cycle-dependent localization of dynactin subunit p150 glued at centrosome.
PubMed ID: 25774020
DOI: 10.1002/jcb.25160
PubMed ID: 26968983
Title: Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility.
PubMed ID: 26968983
PubMed ID: 28394342
Title: Regulation of spindle integrity and mitotic fidelity by BCCIP.
PubMed ID: 28394342
DOI: 10.1038/onc.2017.92
PubMed ID: 16109370
Title: Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex.
PubMed ID: 16109370
PubMed ID: 16949363
Title: Key interaction modes of dynamic +TIP networks.
PubMed ID: 16949363
PubMed ID: 17828277
Title: Structure-function relationship of CAP-Gly domains.
PubMed ID: 17828277
DOI: 10.1038/nsmb1291
PubMed ID: 17828275
Title: CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1.
PubMed ID: 17828275
DOI: 10.1038/nsmb1299
PubMed ID: 12627231
PubMed ID: 15326253
Title: Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS.
PubMed ID: 15326253
PubMed ID: 16240349
Title: Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD.
PubMed ID: 16240349
DOI: 10.1002/ana.20631
PubMed ID: 16505168
Title: A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation.
PubMed ID: 16505168
PubMed ID: 17824900
Title: The p150 subunit of dynactin (DCTN1) gene in multiple sclerosis.
PubMed ID: 17824900
PubMed ID: 19136952
PubMed ID: 19506225
Title: Characterization of DCTN1 genetic variability in neurodegeneration.
PubMed ID: 19506225
PubMed ID: 19279216
Title: Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration.
PubMed ID: 19279216
PubMed ID: 22777741
Title: Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).
PubMed ID: 22777741
PubMed ID: 23874158
Title: Dynactin subunit p150(Glued) is a neuron-specific anti-catastrophe factor.
PubMed ID: 23874158
PubMed ID: 24627108
Title: Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges.
PubMed ID: 24627108
PubMed ID: 24676999
Title: A Novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy.
PubMed ID: 24676999
DOI: 10.1002/mds.25833
PubMed ID: 25185702
Title: Dynactin functions as both a dynamic tether and brake during dynein-driven motility.
PubMed ID: 25185702
DOI: 10.1038/ncomms5807
PubMed ID: 24881494
Title: Three families with Perry syndrome from distinct parts of the world.
PubMed ID: 24881494
PubMed ID: 26972003
Title: Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons.
PubMed ID: 26972003
Sequence Information:
- Length: 1278
- Mass: 141695
- Checksum: 6DCEA5E67856E4BC
- Sequence:
MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMEVAQ ANRHMSLLTA FMPDSFLRPG GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK EFEETMDALQ ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH RLVLTQEQLH QLHSRLIS
Genular Protein ID: 1591215602
Symbol: Q6MZZ3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1278
- Mass: 141551
- Checksum: F2EC8478EF8899FE
- Sequence:
MAQSKRHVYS RTPSGSRMSA EASARPLRVG SRVEVIGKGH RGTVAYVGAT LFATGKWVGV ILDEAKGKND GTVQGRKYFT CDEGHGIFVR QSQIQVFEDG ADTTSPETPD SSASKVLKRE GTDTTAKTSK LRGLKPKKAP TARKTTTRRP KPTRPASTGV AGASSSLGPS GSASAGELSS SEPSTPAQTP LAAPIIPTPV LTSPGAVPPL PSPSKEEEGL RAQVRDLEEK LETLRLKRAE DKAKLKELEK HKIQLEQVQE WKSKMQEQQA DLQRRLKEAR KEAKEALEAK ERYMEEMADT ADAIEMATLD KEMAEERAES LQQEVEALKE RVDELTTDLE ILKAEIEEKG SDGAASSYQL KQLEEQNARL KDALVRMRDL SSSEKQEHVK LQKLMEKKNQ ELEVVRQQRE RLQEELSQAE STIDELKEQV DAALGAEEMV EMLTDRNLNL EEKVRELRET VGDLEAMNEM NDELQENARE TELELREQLD MAGARVREAQ KRVEAAQETV ADYQQTIKKY RQLTAHLQDV NRELTNQQEA SVERQQQPPP ETFDFKIKFA ETKAHAKAIE MELRQMGVAQ ANRHMSLLTA FMPDSFLRPG GDHDCVLVLL LMPRLICKAE LIRKQAQEKF ELSENCSERP GLRGAAGEQL SFAAGLVYSL SLLQATLHRY EHALSQCSVD VYKKVGSLYP EMSAHERSLD FLIELLHKDQ LDETVNVEPL TKAIKYYQHL YSIHLAEQPE DCTMQLADHI KFTQSALDCM SVEVGRLRAF LQGGQEATDI ALLLRDLETS CSDIRQFCKK IRRRMPGTDA PGIPAALAFG PQVSDTLLDC RKHLTWVVAV LQEVAAAAAQ LIAPLAENEG LLVAALEELA FKASEQIYGT PSSSPYECLR QSCNILISTM NKLATAMQEG EYDAERPPSK PPPVELRAAA LRAEITDAEG LGLKLEDRET VIKELKKSLK IKGEELSEAN VRLSLLEKKL DSAAKDADER IEKVQTRLEE TQALLRKKEK GFEETMDALQ ADIDQLEAEK AELKQRLNSQ SKRTIEGLRG PPPSGIATLV SGIAGEEQQR GAIPGQAPGS VPGPGLVKDS PLLLQQISAM RLHISQLQHE NSILKGAQMK ASLASLPPLH VAKLSHEGPG SELPAGALYR KTSQLLETLN QLSTHTHVVD ITRTSPAAKS PSAQLMEQVA QLKSLSDTVE KLKDEVLKET VSQRPGATVP TDFATFPSSA FLRAKEEQQD DTVYMGKVTF SCAAGFGQRH RLVLTQEQLH QLHSRLIS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.