Details for: Isl1

Gene ID: 16392

Symbol: Isl1

Ensembl ID: ENSMUSG00000042258

Description: ISL1 transcription factor, LIM/homeodomain

Associated with

  • Atrial septum morphogenesis
    (GO:0060413)
  • Axonogenesis
    (GO:0007409)
  • Bhlh transcription factor binding
    (GO:0043425)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cardiac cell fate determination
    (GO:0060913)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cardiac right ventricle morphogenesis
    (GO:0003215)
  • Cell differentiation
    (GO:0030154)
  • Cell population proliferation
    (GO:0008283)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Core promoter sequence-specific dna binding
    (GO:0001046)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Heart development
    (GO:0007507)
  • Heart morphogenesis
    (GO:0003007)
  • Innervation
    (GO:0060384)
  • Lim domain binding
    (GO:0030274)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Metal ion binding
    (GO:0046872)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of epithelial cell proliferation
    (GO:0050680)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intracellular estrogen receptor signaling pathway
    (GO:0033147)
  • Negative regulation of mesenchymal cell proliferation
    (GO:0072201)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of protein-containing complex assembly
    (GO:0031333)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neural crest cell migration
    (GO:0001755)
  • Neuron differentiation
    (GO:0030182)
  • Neuron fate commitment
    (GO:0048663)
  • Neuron fate specification
    (GO:0048665)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nuclear receptor binding
    (GO:0016922)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Outflow tract septum morphogenesis
    (GO:0003148)
  • Pancreas development
    (GO:0031016)
  • Peripheral nervous system neuron axonogenesis
    (GO:0048936)
  • Peripheral nervous system neuron development
    (GO:0048935)
  • Pharyngeal system development
    (GO:0060037)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of calcium ion import
    (GO:0090280)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna binding
    (GO:0043388)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of granulocyte colony-stimulating factor production
    (GO:0071657)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of interleukin-1 alpha production
    (GO:0032730)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of macrophage colony-stimulating factor production
    (GO:1901258)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of smoothened signaling pathway
    (GO:0045880)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type b pancreatic cell apoptotic process
    (GO:2000676)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of secondary heart field cardioblast proliferation
    (GO:0003266)
  • Retinal ganglion cell axon guidance
    (GO:0031290)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secondary heart field specification
    (GO:0003139)
  • Sensory system development
    (GO:0048880)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sinoatrial node cell development
    (GO:0060931)
  • Spinal cord motor neuron cell fate specification
    (GO:0021520)
  • Spinal cord motor neuron differentiation
    (GO:0021522)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Trigeminal nerve development
    (GO:0021559)
  • Ventricular cardiac muscle tissue morphogenesis
    (GO:0055010)
  • Visceral motor neuron differentiation
    (GO:0021524)

Other Information

Genular Protein ID: 2828275061

Symbol: ISL1_MOUSE

Name: Insulin gene enhancer protein ISL-1

UniProtKB Accession Codes:

P61372 P20663 P47894 Q812D8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 91 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SASBDB 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 14664703

Title: Isolation and characterization of an alternatively spliced variant of transcription factor Islet-1.

PubMed ID: 14664703

DOI: 10.1677/jme.0.0310419

PubMed ID: 14667410

Title: Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart.

PubMed ID: 14667410

DOI: 10.1016/s1534-5807(03)00363-0

PubMed ID: 18539116

Title: A regulatory network to segregate the identity of neuronal subtypes.

PubMed ID: 18539116

DOI: 10.1016/j.devcel.2008.03.021

PubMed ID: 22343712

Title: CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy.

PubMed ID: 22343712

DOI: 10.1161/circresaha.111.259663

PubMed ID: 24643061

Title: Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells.

PubMed ID: 24643061

DOI: 10.1371/journal.pone.0092105

PubMed ID: 25775587

Title: Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate.

PubMed ID: 25775587

DOI: 10.1073/pnas.1421535112

PubMed ID: 36112854

Title: The effects of beta-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination.

PubMed ID: 36112854

DOI: 10.1177/15353702221119792

PubMed ID: 18583962

Title: Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.

PubMed ID: 18583962

DOI: 10.1038/emboj.2008.123

Sequence Information:

  • Length: 349
  • Mass: 39036
  • Checksum: 4DB82FD09154F404
  • Sequence:
    • MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCFV 
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 
TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

Genular Protein ID: 2613388291

Symbol: Q8BTH7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BTH7

Database IDs:

AGR 1 ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 6 Gene3D 2 Genevisible 1 InterPro 6 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 2 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 349
  • Mass: 39085
  • Checksum: F2001865094EC9B9
  • Sequence:
    • MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCLV 
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 
TTRVRTVLNE KQLHTLRTWY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.