Genular: Defining Cellular Identity and Function

Details for: Itch

Gene ID: 16396

Symbol: Itch

Ensembl ID: ENSMUSG00000027598

Description: itchy, E3 ubiquitin protein ligase

Associated with

Activated notch1 transmits signal to the nucleus
(R-MMU-2122948)
Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Downregulation of erbb4 signaling
(R-MMU-1253288)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation of necroptotic cell death
(R-MMU-5675482)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates transcription of genes involved in differentiation of hscs
(R-MMU-8939236)
Signaling by erbb4
(R-MMU-1236394)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by notch
(R-MMU-157118)
Signaling by notch1
(R-MMU-1980143)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by runx1
(R-MMU-8878171)
Apoptotic process
(GO:0006915)
Arrestin family protein binding
(GO:1990763)
Cd4-positive, alpha-beta t cell proliferation
(GO:0035739)
Cell cortex
(GO:0005938)
Cxcr chemokine receptor binding
(GO:0045236)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Intracellular membrane-bounded organelle
(GO:0043231)
Ligase activity
(GO:0016874)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cd4-positive, alpha-beta t cell proliferation
(GO:2000562)
Negative regulation of cytoplasmic pattern recognition receptor signaling pathway
(GO:0039532)
Negative regulation of defense response to virus
(GO:0050687)
Negative regulation of jnk cascade
(GO:0046329)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of protein catabolic process
(GO:0045732)
Positive regulation of receptor catabolic process
(GO:2000646)
Positive regulation of t cell anergy
(GO:0002669)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex
(GO:0032991)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein k29-linked ubiquitination
(GO:0035519)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Receptor internalization
(GO:0031623)
Regulation of protein deubiquitination
(GO:0090085)
Ribonucleoprotein complex binding
(GO:0043021)
T cell anergy
(GO:0002870)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase Itchy

Genular Protein ID: 2692406133

Symbol: ITCH_MOUSE

Name: E3 ubiquitin-protein ligase Itchy

UniProtKB Accession Codes:

Q8C863 O54971

Database IDs:

Citations:

PubMed ID: 9462742

Title: The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice.

PubMed ID: 9462742

DOI: 10.1038/ng0298-143

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11748237

Title: N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein.

PubMed ID: 11748237

DOI: 10.1074/jbc.m110443200

PubMed ID: 11828324

Title: Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.

PubMed ID: 11828324

DOI: 10.1038/ni763

PubMed ID: 10940313

Title: Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase.

PubMed ID: 10940313

DOI: 10.1074/jbc.m007300200

PubMed ID: 11782481

Title: The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch.

PubMed ID: 11782481

DOI: 10.1074/jbc.m111384200

PubMed ID: 15358865

Title: Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch.

PubMed ID: 15358865

DOI: 10.1126/science.1099414

PubMed ID: 17137798

Title: Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.

PubMed ID: 17137798

DOI: 10.1016/j.immuni.2006.10.012

PubMed ID: 16446428

Title: Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.

PubMed ID: 16446428

DOI: 10.1073/pnas.0510664103

PubMed ID: 17592138

Title: The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.

PubMed ID: 17592138

DOI: 10.1073/pnas.0701773104

PubMed ID: 18628966

Title: AIP4/Itch regulates Notch receptor degradation in the absence of ligand.

PubMed ID: 18628966

DOI: 10.1371/journal.pone.0002735

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20392206

Title: The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid.

PubMed ID: 20392206

DOI: 10.1111/j.1742-4658.2010.07562.x

PubMed ID: 23146885

Title: Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch.

PubMed ID: 23146885

DOI: 10.1038/embor.2012.164

PubMed ID: 25632008

Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.

PubMed ID: 25632008

DOI: 10.4049/jimmunol.1402742

PubMed ID: 26854353

Title: Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3.

PubMed ID: 26854353

DOI: 10.1021/acs.biochem.5b01218

PubMed ID: 15971201

Title: Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain.

PubMed ID: 15971201

DOI: 10.1002/prot.20466

PubMed ID: 17437719

Title: NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands.

PubMed ID: 17437719

DOI: 10.1016/j.str.2007.03.005

Sequence Information:

Length: 864
Mass: 98994
Checksum: 905FDBE00A1EA7EA
Sequence:

MSDSGPQLDS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 
NSPKWKQPLT VIVTPTSKLC FRVWSHQTLK SDVLLGTAGL DIYETLKSNN MKLEEVVMTL 
QLVGDKEPTE TMGDLSVCLD GLQVEAEVVT NGETSCSEST TQNDDGCRTR DDTRVSTNGS 
EDPEVAASGE NKRANGNNSP SLSNGGFKPS RPPRPSRPPP PTPRRPASVN GSPSTNSDSD 
GSSTGSLPPT NTNVNTSTSE GATSGLIIPL TISGGSGPRP LNTVSQAPLP PGWEQRVDQH 
GRVYYVDHVE KRTTWDRPEP LPPGWERRVD NMGRIYYVDH FTRTTTWQRP TLESVRNYEQ 
WQLQRSQLQG AMQQFNQRFI YGNQDLFATS QNKEFDPLGP LPPGWEKRTD SNGRVYFVNH 
NTRITQWEDP RSQGQLNEKP LPEGWEMRFT VDGIPYFVDH NRRATTYIDP RTGKSALDNG 
PQIAYVRDFK AKVQYFRFWC QQLAMPQHIK ITVTRKTLFE DSFQQIMSFS PQDLRRRLWV 
IFPGEEGLDY GGVAREWFFL LSHEVLNPMY CLFEYAGKDN YCLQINPASY INPDHLKYFR 
FIGRFIAMAL FHGKFIDTGF SLPFYKRILN KPVGLKDLES IDPEFYNSLI WVKENNIEEC 
GLEMYFSVDK EILGEIKSHD LKPNGGNILV TEENKEEYIR MVAEWRLSRG VEEQTQAFFE 
GFNEILPQQY LQYFDAKELE VLLCGMQEID LNDWQRHAIY RHYTRTSKQI MWFWQFVKEI 
DNEKRMRLLQ FVTGTCRLPV GGFADLMGSN GPQKFCIEKV GKENWLPRSH TCFNRLDLPP 
YKSYEQLKEK LLFAIEETEG FGQE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itch

Associated with

Other Information

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. PubMed ID: 9462742

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. PubMed ID: 11748237

Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation. PubMed ID: 11828324

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase. PubMed ID: 10940313

The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch. PubMed ID: 11782481

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. PubMed ID: 15358865

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. PubMed ID: 17137798

Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. PubMed ID: 16446428

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. PubMed ID: 17592138

AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PubMed ID: 18628966

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. PubMed ID: 20392206

Phosphatidylinositol 4-kinase IIalpha function at endosomes is regulated by the ubiquitin ligase Itch. PubMed ID: 23146885

Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. PubMed ID: 25632008

Regulation of Itch and Nedd4 E3 Ligase Activity and Degradation by LRAD3. PubMed ID: 26854353

Phosphorylation of either Ser16 or Thr30 does not disrupt the structure of the Itch E3 ubiquitin ligase third WW domain. PubMed ID: 15971201

NMR structural studies of the ItchWW3 domain reveal that phosphorylation at T30 inhibits the interaction with PPxY-containing ligands. PubMed ID: 17437719