Genular: Defining Cellular Identity and Function

Details for: Itga2

Gene ID: 16398

Symbol: Itga2

Ensembl ID: ENSMUSG00000015533

Description: integrin alpha 2

Associated with

Ecm proteoglycans
(R-MMU-3000178)
Extracellular matrix organization
(R-MMU-1474244)
Integrin cell surface interactions
(R-MMU-216083)
Met activates ptk2 signaling
(R-MMU-8874081)
Met promotes cell motility
(R-MMU-8875878)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Syndecan interactions
(R-MMU-3000170)
Amyloid-beta binding
(GO:0001540)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Basal part of cell
(GO:0045178)
Cell-cell adhesion
(GO:0098609)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Collagen-activated signaling pathway
(GO:0038065)
Collagen binding
(GO:0005518)
Collagen binding involved in cell-matrix adhesion
(GO:0098639)
Collagen receptor activity
(GO:0038064)
Detection of mechanical stimulus involved in sensory perception of pain
(GO:0050966)
External side of plasma membrane
(GO:0009897)
Focal adhesion
(GO:0005925)
Focal adhesion assembly
(GO:0048041)
Hypotonic response
(GO:0006971)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin alpha2-beta1 complex
(GO:0034666)
Integrin binding
(GO:0005178)
Integrin complex
(GO:0008305)
Laminin binding
(GO:0043236)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell projection organization
(GO:0031346)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of phagocytosis, engulfment
(GO:0060100)
Positive regulation of positive chemotaxis
(GO:0050927)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of translation
(GO:0045727)
Positive regulation of transmission of nerve impulse
(GO:0051971)
Presynapse
(GO:0098793)
Protein-containing complex binding
(GO:0044877)
Skin morphogenesis
(GO:0043589)
Substrate-dependent cell migration
(GO:0006929)

Other Information

Proteins

Integrin alpha-2

Genular Protein ID: 4180607974

Symbol: ITA2_MOUSE

Name: Integrin alpha-2

UniProtKB Accession Codes:

Q62469 Q62163 Q6P1C7

Database IDs:

Citations:

PubMed ID: 8081889

Title: The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding.

PubMed ID: 8081889

DOI: 10.3109/15419069409004432

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7521231

Title: Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development.

PubMed ID: 7521231

DOI: 10.1002/aja.1001990405

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1178
Mass: 128955
Checksum: 62FAEA820242A9B6
Sequence:

MGPGQAGGAL LLRLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ QLTNPQGNWL 
LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI SNVTEIKTNM SLGLTLTRNP 
GTGGFLTCGP LWAHQCGNQY YATGICSDVS PDFQFLTSFS PAVQACPSLV DVVVVCDESN 
SIYPWEAVKN FLVKFVTGLD IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR 
QHGGDLTNTF RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE 
ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK AGTLGEQIFS 
IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD WSGTLVQETS HKPVIFPKQA 
FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR 
GDQIGSYFGS VLCSVDVDKD TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL 
EGPEGTGNAR FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK 
ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA DVAIEALFTP 
DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD ADGHSSRVTS RGVFRENSER 
FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP LDLRVDISLE NPGTSPALEA YSETVKVFSI 
PFYKECGSDG ICISDLILDV QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA 
EFSENLFFAS FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ 
NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS DENAPSVIKS 
VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL LYLTGIQTDQ AGDISCTAEI 
NPLKLPHTAP SVSFKNENFR HTKELDCRTT SCSNITCWLK DLHMKAEYFI NVTTRVWNRT 
FAASTFQTVQ LTAAAEIDTH NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI 
LLLLAMTAGL WKLGFFKRQY KKMGQNPDEM DETTELNS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itga2

Associated with

Other Information

The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding. PubMed ID: 8081889

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development. PubMed ID: 7521231