Genular: Defining Cellular Identity and Function

Details for: Itga2b

Gene ID: 16399

Symbol: Itga2b

Ensembl ID: ENSMUSG00000034664

Description: integrin alpha 2b

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Ecm proteoglycans
(R-MMU-3000178)
Extracellular matrix organization
(R-MMU-1474244)
Grb2:sos provides linkage to mapk signaling for integrins
(R-MMU-354194)
Hemostasis
(R-MMU-109582)
Integrin cell surface interactions
(R-MMU-216083)
Integrin signaling
(R-MMU-354192)
L1cam interactions
(R-MMU-373760)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Nervous system development
(R-MMU-9675108)
P130cas linkage to mapk signaling for integrins
(R-MMU-372708)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Angiogenesis
(GO:0001525)
Cell-cell adhesion
(GO:0098609)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell surface
(GO:0009986)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular matrix binding
(GO:0050840)
Fibrinogen binding
(GO:0070051)
Focal adhesion
(GO:0005925)
Identical protein binding
(GO:0042802)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Integrin complex
(GO:0008305)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Plasma membrane
(GO:0005886)
Positive regulation of leukocyte migration
(GO:0002687)

Other Information

Proteins

Integrin alpha-IIb

Genular Protein ID: 386938842

Symbol: ITA2B_MOUSE

Name: Integrin alpha-IIb

UniProtKB Accession Codes:

Q9QUM0 Q3U3R7 Q64229 Q9Z2M0

Database IDs:

Citations:

PubMed ID: 10572112

Title: Characterization of the murine platelet alphaIIb gene and encoded cDNA.

PubMed ID: 10572112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1512266

Title: Identification of the alpha IIb beta 3 integrin in murine tumor cells.

PubMed ID: 1512266

DOI: 10.1016/s0021-9258(18)41927-8

PubMed ID: 10713093

Title: Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3.

PubMed ID: 10713093

DOI: 10.1074/jbc.275.11.7795

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24429998

Title: Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling.

PubMed ID: 24429998

DOI: 10.1160/th13-09-0738

Sequence Information:

Length: 1033
Mass: 112678
Checksum: 7B4826E32B9130B1
Sequence:

MARASCAWHS LWLLQWTPLF LGPSAVPPVW ALNLDSEKFS VYAGPNGSHF GFSVDFHKDK 
HGSVSIVVGA PRALNASQEE TGAVFLCPWK ANGGKCNPLL FDLRDETRNL GFQIFQTFKT 
GQGLGASVVS WNDVIVACAP WQHWNVLEKR DEAEKTPVGG CFLAQLQSGG RAEYSPCRAN 
TMSSVYAESF RGDKRYCEAG FSLAVTQAGE LVLGAPGGYF FLGLLARVPI ENIISSYRPG 
TLLWHVSNQR FTYDNSNPVF FDGYRGYSVA VGEFDGDPST TEYVSGAPTW SWTLGAVEIL 
DSYYQPLHRL HGEQMASYFG HSVAVTDVNG DGRHDLLVGA PLYMESRADR KLAEVGRVYL 
FLQPKGPQAL STPTLLLTGT QLYGRFGSAI APLGDLNRDG YNDIAVAAPY GGPSGQGQVL 
IFLGQSEGLS PRPSQVLDSP FPTGSGFGFS LRGAVDIDDN GYPDLIVGAY GASKVAVYRA 
QPVVMATVQL MVQDSLNPTL KNCVLDQTKT PVSCFNIQMC VGATGHNIPQ KLHLKAELQL 
DLQKPRQGRR VLLLASQQAS LTLSLDLGGR DKPICHTTGA FLRDEADFRD KLSPIVLSLN 
VSLPPEETGG APAVVLHGET HVQEQTRIIL DCGEDDLCVP QLRLTATAGD SPLLIGADNV 
LELKIEAAND GEGAYEAELA VHLPPGAHYM RALSNIEGFE RLVCTQKKEN ESRVALCELG 
NPMKKDTRIG ITMLVSVENL EEAGESVSFQ LQVRSKNSQN PNSKVVMLPV AIQAEATVEL 
RGNSFPASLV VAAEEGDREQ EDLDRWVSRL EHTYELHNIG PGTVNGLRLL IHIPGQSQPS 
DLLYILDVQP QGGLLCSTQP SPKVDWKLST PSPSSIRPVH HQRERRQAFL QGPKPGQQDP 
VLVSCDGSAS CTVVECELRE MVRGQRAMVT VQVMLGLSSL RQRPQEQFVL QSHAWFNVSS 
LPYSVPVVSL PSGQARVQTQ LLRALEERAI PVWWVLVGVL GGLLLLTLLV LAMWKAGFFK 
RNRPPLEEDE EEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itga2b

Associated with

Other Information

Characterization of the murine platelet alphaIIb gene and encoded cDNA. PubMed ID: 10572112

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the alpha IIb beta 3 integrin in murine tumor cells. PubMed ID: 1512266

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alphaIIbbeta3. PubMed ID: 10713093

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling. PubMed ID: 24429998