Details for: AP1G1

Gene ID: 164

Symbol: AP1G1

Ensembl ID: ENSG00000166747

Description: adaptor related protein complex 1 subunit gamma 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.54
    Marker Score: 4430
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.8
    Marker Score: 4422.5
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.79
    Marker Score: 1972
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.76
    Marker Score: 1856
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.76
    Marker Score: 3858
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.66
    Marker Score: 6777
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.66
    Marker Score: 6934
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.64
    Marker Score: 60384
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.61
    Marker Score: 99117
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.61
    Marker Score: 16595
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.6
    Marker Score: 1236
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.57
    Marker Score: 917
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.57
    Marker Score: 6514
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.57
    Marker Score: 14920
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.57
    Marker Score: 59577
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.56
    Marker Score: 30993
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.56
    Marker Score: 33230
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.55
    Marker Score: 13311
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.52
    Marker Score: 3843
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.52
    Marker Score: 14317
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.52
    Marker Score: 22683
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.52
    Marker Score: 5864
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.5
    Marker Score: 1727
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.46
    Marker Score: 11189
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.45
    Marker Score: 1947
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.43
    Marker Score: 1234
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.42
    Marker Score: 595
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.42
    Marker Score: 1528
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.41
    Marker Score: 411
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.4
    Marker Score: 821
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2160
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.4
    Marker Score: 1690
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.35
    Marker Score: 425
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.33
    Marker Score: 903
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.3
    Marker Score: 2507
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.29
    Marker Score: 679
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.27
    Marker Score: 760
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.24
    Marker Score: 1826
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.23
    Marker Score: 497
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.23
    Marker Score: 1484
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.23
    Marker Score: 1763
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.21
    Marker Score: 812
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.21
    Marker Score: 21476
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.19
    Marker Score: 576
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.16
    Marker Score: 1647
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.14
    Marker Score: 563
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.14
    Marker Score: 311
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.13
    Marker Score: 1148
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.13
    Marker Score: 5234
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.13
    Marker Score: 1198
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.12
    Marker Score: 3015
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.12
    Marker Score: 2559
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.11
    Marker Score: 1063
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.11
    Marker Score: 1842
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.11
    Marker Score: 414
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1
    Marker Score: 17739
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.09
    Marker Score: 36922
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.09
    Marker Score: 2572
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.09
    Marker Score: 403
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.09
    Marker Score: 767
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.08
    Marker Score: 6953
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.08
    Marker Score: 4658
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.08
    Marker Score: 367
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.08
    Marker Score: 3700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.07
    Marker Score: 930
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.07
    Marker Score: 597
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.05
    Marker Score: 303
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16406
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.05
    Marker Score: 302
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.04
    Marker Score: 518
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.04
    Marker Score: 4342
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.04
    Marker Score: 953.5
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.03
    Marker Score: 307
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.03
    Marker Score: 2464
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.03
    Marker Score: 373
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3788
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.02
    Marker Score: 1320
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.02
    Marker Score: 707
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.02
    Marker Score: 1152
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1
    Marker Score: 3540
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1
    Marker Score: 580
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71621
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47846
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.99
    Marker Score: 1225
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.99
    Marker Score: 400
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.98
    Marker Score: 1223
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.97
    Marker Score: 1011
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.97
    Marker Score: 5217
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.95
    Marker Score: 348
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.95
    Marker Score: 8241
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.95
    Marker Score: 647
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.94
    Marker Score: 1175
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.94
    Marker Score: 6003
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2389
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.94
    Marker Score: 1003
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.94
    Marker Score: 1096
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.94
    Marker Score: 942
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.93
    Marker Score: 379
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 478

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Other Information

**Key characteristics:** - AP1G1 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the AP1 family of adaptor proteins, which are involved in the regulation of cell signaling pathways. - AP1G1 is expressed in a variety of cell types, including germ cell, glandular epithelial cell, corneal epithelial cell, conjunctival epithelial cell, ciliary muscle cell, neuron, pigmented epithelial cell, pvalb GABAergic cortical interneuron, L2/3-6 intratelencephalic projecting glutamatergic neuron, and dopaminergic neuron. **Pathways and functions:** - AP1G1 is involved in the regulation of the adaptive immune system by recruiting immune receptors to clathrin adapters. - It is also involved in the regulation of collagen binding by interacting with collagen receptors. - AP1G1 is involved in Golgi-associated vesicle biogenesis by interacting with the Golgi complex. - It is involved in the regulation of cell surface receptors by recruiting them to clathrin adapters. - AP1G1 is involved in the regulation of viral infection pathways by interacting with viral proteins. **Clinical significance:** - Mutations in AP1G1 have been linked to several human diseases, including HIV-1 infection. - AP1G1 is a potential target for the treatment of HIV-1 infection.

Genular Protein ID: 1305238847

Symbol: AP1G1_HUMAN

Name: AP-1 complex subunit gamma-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9653655

Title: Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG).

PubMed ID: 9653655

DOI: 10.1006/geno.1998.5289

PubMed ID: 9733768

Title: Identification and characterization of novel clathrin adaptor-related proteins.

PubMed ID: 9733768

DOI: 10.1074/jbc.273.38.24693

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 12773381

Title: Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes.

PubMed ID: 12773381

DOI: 10.1093/emboj/cdg257

PubMed ID: 14665628

Title: Definition of the consensus motif recognized by gamma-adaptin ear domains.

PubMed ID: 14665628

DOI: 10.1074/jbc.m311873200

PubMed ID: 15775984

Title: Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking.

PubMed ID: 15775984

DOI: 10.1038/sj.emboj.7600600

PubMed ID: 15598649

Title: AP-1 and AP-3 facilitate lysosomal targeting of Batten disease protein CLN3 via its dileucine motif.

PubMed ID: 15598649

DOI: 10.1074/jbc.m411862200

PubMed ID: 15758025

Title: The aftiphilin/p200/gamma-synergin complex.

PubMed ID: 15758025

DOI: 10.1091/mbc.e04-12-1077

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 12042876

Title: Structural basis for the accessory protein recruitment by the gamma-adaptin ear domain.

PubMed ID: 12042876

DOI: 10.1038/nsb808

PubMed ID: 34102099

Title: De novo and bi-allelic variants in AP1G1 cause neurodevelopmental disorder with developmental delay, intellectual disability, and epilepsy.

PubMed ID: 34102099

DOI: 10.1016/j.ajhg.2021.05.007

Sequence Information:

  • Length: 822
  • Mass: 91351
  • Checksum: 42EF40223DFBA5E9
  • Sequence:
  • MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV AKLLYMHMLG 
    YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH LLMTNCIKND LNHSTQFVQG 
    LALCTLGCMG SSEMCRDLAG EVEKLLKTSN SYLRKKAALC AVHVIRKVPE LMEMFLPATK 
    NLLNEKNHGV LHTSVVLLTE MCERSPDMLA HFRKLVPQLV RILKNLIMSG YSPEHDVSGI 
    SDPFLQVRIL RLLRILGRND DDSSEAMNDI LAQVATNTET SKNVGNAILY ETVLTIMDIK 
    SESGLRVLAI NILGRFLLNN DKNIRYVALT SLLKTVQTDH NAVQRHRSTI VDCLKDLDVS 
    IKRRAMELSF ALVNGNNIRG MMKELLYFLD SCEPEFKADC ASGIFLAAEK YAPSKRWHID 
    TIMRVLTTAG SYVRDDAVPN LIQLITNSVE MHAYTVQRLY KAILGDYSQQ PLVQVAAWCI 
    GEYGDLLVSG QCEEEEPIQV TEDEVLDILE SVLISNMSTS VTRGYALTAI MKLSTRFTCT 
    VNRIKKVVSI YGSSIDVELQ QRAVEYNALF KKYDHMRSAL LERMPVMEKV TTNGPTEIVQ 
    TNGETEPAPL ETKPPPSGPQ PTSQANDLLD LLGGNDITPV IPTAPTSKPS SAGGELLDLL 
    GDINLTGAPA AAPAPASVPQ ISQPPFLLDG LSSQPLFNDI AAGIPSITAY SKNGLKIEFT 
    FERSNTNPSV TVITIQASNS TELDMTDFVF QAAVPKTFQL QLLSPSSSIV PAFNTGTITQ 
    VIKVLNPQKQ QLRMRIKLTY NHKGSAMQDL AEVNNFPPQS WQ

Genular Protein ID: 2239090848

Symbol: Q8IY97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 825
  • Mass: 91757
  • Checksum: 0FBEA78600892003
  • Sequence:
  • MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV AKLLYMHMLG 
    YPAHFGQLEC FKLIASQKFT DKRIGYLGAM LLLDERQDVH LLMTNCIKND LNHSTQFVQG 
    LALCTLGCMG SSEMCRDLAG EVEKLLKTSN SYLRKKAALC AVHVIRKVPE LMEMFLPATK 
    NLLNEKNHGV LHTSVVLLTE MCERSPDMLA HFRKNEKLVP QLVRILKNLI MSGYSPEHDV 
    SGISDPFLQV RILRLLRILG RNDDDSSEAM NDILAQVATN TETSKNVGNA ILYETVLTIM 
    DIKSESGLRV LAINILGRFL LNNDKNIRYV ALTSLLKTVQ TDHNAVQRHR STIVDCLKDL 
    DVSIKRRAME LSFALVNGNN IRGMMKELLY FLDSCEPEFK ADCASGIFLA AEKYAPSKRW 
    HIDTIMRVLT TAGSYVRDDA VPNLIQLITN SVEMHAYTVQ RLYKAILGDY SQQPLVQVAA 
    WCIGEYGDLL VSGQCEEEEP IQVTEDEVLD ILESVLISNM STSVTRGYAL TAIMKLSTRF 
    TCTVNRIKKV VSIYGSSIDV ELQQRAVEYN ALFKKYDHMR SALLERMPVM EKVTTNGPTE 
    IVQTNGETEP APLETKPPPS GPQPTSQAND LLDLLGGNDI TPVIPTAPTS KPSSAGGELL 
    DLLGDINLTG APAAAPAPAS VPQISQPPFL LDGLSSQPLF NDIAAGIPSI TAYSKNGLKI 
    EFTFERSNTN PSVTVITIQA SNSTELDMTD FVFQAAVPKT FQLQLLSPSS SIVPAFNTGT 
    ITQVIKVLNP QKQQLRMRIK LTYNHKGSAM QDLAEVNNFP PQSWQ

Genular Protein ID: 2421335722

Symbol: A0A140VJE7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 825
  • Mass: 91723
  • Checksum: 1F5EA713F104978C
  • Sequence:
  • MPAPIRLREL IRTIRTARTQ AEEREMIQKE CAAIRSSFRE EDNTYRCRNV AKLLYMHMLG 
    YPAHFGQLEC LKLIASQKFT DKRIGYLGAM LLLDERQDVH LLMTNCIKND LNHSTQFVQG 
    LALCTLGCMG SSEMCRDLAG EVEKLLKTSN SYLRKKAALC AVHVIRKVPE LMEMFLPATK 
    NLLNEKNHGV LHTSVVLLTE MCERSPDMLA HFRKNEKLVP QLVRILKNLI MSGYSPEHDV 
    SGISDPFLQV RILRLLRILG RNDDDSSEAM NDILAQVATN TETSKNVGNA ILYETVLTIM 
    DIKSESGLRV LAINILGRFL LNNDKNIRYV ALTSLLKTVQ TDHNAVQRHR STIVDCLKDL 
    DVSIKRRAME LSFALVNGNN IRGMMKELLY FLDSCEPEFK ADCASGIFLA AEKYAPSKRW 
    HIDTIMRVLT TAGSYVRDDA VPNLIQLITN SVEMHAYTVQ RLYKAILGDY SQQPLVQVAA 
    WCIGEYGDLL VSGQCEEEEP IQVTEDEVLD ILESVLISNM STSVTRGYAL TAIMKLSTRF 
    TCTVNRIKKV VSIYGSSIDV ELQQRAVEYN ALFKKYDHMR SALLERMPVM EKVTTNGPTE 
    IVQTNGETEP APLETKPPPS GPQPTSQAND LLDLLGGNDI TPVIPTAPTS KPSSAGGELL 
    DLLGDINLTG APAAAPAPAS VPQISQPPFL LDGLSSQPLF NDIAAGIPSI TAYSKNGLKI 
    EFTFERSNTN PSVTVITIQA SNSTELDMTD FVFQAAVPKT FQLQLLSPSS SIVPAFNTGT 
    ITQVIKVLNP QKQQLRMRIK LTYNHKGSAM QDLAEVNNFP PQSWQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.