Genular: Defining Cellular Identity and Function

Details for: Itgav

Gene ID: 16410

Symbol: Itgav

Ensembl ID: ENSMUSG00000027087

Description: integrin alpha V

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing-cross presentation
(R-MMU-1236975)
Axon guidance
(R-MMU-422475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cross-presentation of particulate exogenous antigens (phagosomes)
(R-MMU-1236973)
Developmental biology
(R-MMU-1266738)
Ecm proteoglycans
(R-MMU-3000178)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Integrin cell surface interactions
(R-MMU-216083)
L1cam interactions
(R-MMU-373760)
Molecules associated with elastic fibres
(R-MMU-2129379)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Pecam1 interactions
(R-MMU-210990)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Syndecan interactions
(R-MMU-3000170)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Angiogenesis
(GO:0001525)
Apolipoprotein a-i-mediated signaling pathway
(GO:0038027)
Apoptotic cell clearance
(GO:0043277)
Blood vessel development
(GO:0001568)
C-x3-c chemokine binding
(GO:0019960)
Calcium ion transmembrane transport
(GO:0070588)
Cell-cell adhesion
(GO:0098609)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Detection of molecule of bacterial origin
(GO:0032490)
Endodermal cell differentiation
(GO:0035987)
Endothelial cell migration
(GO:0043542)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular matrix binding
(GO:0050840)
Extracellular matrix protein binding
(GO:1990430)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Fibroblast growth factor binding
(GO:0017134)
Fibronectin binding
(GO:0001968)
Focal adhesion assembly
(GO:0048041)
Gonad morphogenesis
(GO:0035262)
Heterotypic cell-cell adhesion
(GO:0034113)
Inflammatory response
(GO:0006954)
Insulin-like growth factor i binding
(GO:0031994)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Negative chemotaxis
(GO:0050919)
Negative regulation of entry of bacterium into host cell
(GO:2000536)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of lipoprotein metabolic process
(GO:0050748)
Negative regulation of low-density lipoprotein receptor activity
(GO:1905598)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Neuregulin binding
(GO:0038132)
Nucleus
(GO:0005634)
Opsonin binding
(GO:0001846)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of small gtpase mediated signal transduction
(GO:0051057)
Protease binding
(GO:0002020)
Protein kinase c binding
(GO:0005080)
Regulation of bone resorption
(GO:0045124)
Regulation of phagocytosis
(GO:0050764)
Regulation of transforming growth factor beta activation
(GO:1901388)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to nitric oxide
(GO:0071731)
Signaling receptor binding
(GO:0005102)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Symbiont entry into host cell
(GO:0046718)
T cell activation
(GO:0042110)
Transforming growth factor beta production
(GO:0071604)
Trophoblast giant cell differentiation
(GO:0060707)
Voltage-gated calcium channel activity
(GO:0005245)

Other Information

Proteins

Integrin alpha-V

Genular Protein ID: 1592794561

Symbol: ITAV_MOUSE

Name: Integrin alpha-V

UniProtKB Accession Codes:

P43406 A2AKI6

Database IDs:

Citations:

PubMed ID: 8601592

Title: Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development.

PubMed ID: 8601592

DOI: 10.1083/jcb.132.6.1161

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9827803

Title: Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.

PubMed ID: 9827803

DOI: 10.1016/s0092-8674(00)81618-9

PubMed ID: 10025398

Title: The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.

PubMed ID: 10025398

DOI: 10.1016/s0092-8674(00)80545-0

PubMed ID: 11323698

Title: gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.

PubMed ID: 11323698

DOI: 10.1038/87749

PubMed ID: 11805835

Title: Fibulin-5/DANCE is essential for elastogenesis in vivo.

PubMed ID: 11805835

DOI: 10.1038/415171a

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24935931

Title: gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.

PubMed ID: 24935931

DOI: 10.4049/jimmunol.1302772

PubMed ID: 25127859

Title: Release of active TGF-beta1 from the latent TGF-beta1/GARP complex on T regulatory cells is mediated by integrin beta8.

PubMed ID: 25127859

DOI: 10.4049/jimmunol.1401102

Sequence Information:

Length: 1044
Mass: 115360
Checksum: 417FD73D776B5918
Sequence:

MAAPGRLLLR PRPGGLLLLL PGLLLPLADA FNLDVESPAE YAGPEGSYFG FAVDFFEPST 
SSRMFLLVGA PKANTTQPGI VEGGQVLKCE CSSSRRCQPI EFDSTGNRDY AKDDPLEFKS 
HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSKNIDAD 
GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT 
RTAQAIFDDS YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 
QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ RAVGDFQTTK 
LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GLVYIFNGRS TGLNSVPSQI 
LEGQWAAQSM PPSFGYSMKG ATDVDRNGYP DLVVGAFGVD RAVLYRARPV VTVNAGLEVY 
PSILNQDNKI CPLPGTALKV SCFNVRFCLK ADGKGTLPRK LHFQVELLLD KLKQKGAIRR 
ALFLHNRSPV HSKTMTVFRG GQMQCEELVA YLRDESEFRD KLTPITIFME YRLDQRTAAD 
ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV NSDQKKIYIG DDNPLTLTVK 
AQNQGEGAYE AELIVSIPPQ ADFIGVVRNN EALARLSCAF KTENQTRQVV CDLGNPMKAG 
TQLLAGLRFS VHQQSEMDTS VKFDLKIQSS NSFDNVSPVV SYKVDLAVLA AVEIRGVSSP 
DHIFLPIPNW EYKENPETEE DVGPIVQHIY ELRNNGPSSF SKAILNLQWP YKYNNNTLLY 
ILHYDIDGPM NCTADTEINP LRIKTPEKND TAAAGQGERN HLITKRDLTL REGDVHTLGC 
GIAKCLQITC QVGRLDRGKS AILYVKSLLW TETFMNKENQ NHSYSLKSSA SFNIIEFPYK 
NLPIEDLFNS TLVTTNITWG IQPAPMPVPV WVIILAVLAG LLLLAVLVFV MYRMGFFKRV 
RPPQEEQERE QLQPHENGEG NSET

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itgav

Associated with

Other Information

Cloning of mouse integrin alphaV cDNA and role of the alphaV-related matrix receptors in metanephric development. PubMed ID: 8601592

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins. PubMed ID: 9827803

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis. PubMed ID: 10025398

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. PubMed ID: 11323698

Fibulin-5/DANCE is essential for elastogenesis in vivo. PubMed ID: 11805835

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. PubMed ID: 24935931

Release of active TGF-beta1 from the latent TGF-beta1/GARP complex on T regulatory cells is mediated by integrin beta8. PubMed ID: 25127859