Genular: Defining Cellular Identity and Function

Details for: Itgb3

Gene ID: 16416

Symbol: Itgb3

Ensembl ID: ENSMUSG00000020689

Description: integrin beta 3

Associated with

Axon guidance
(R-MMU-422475)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Developmental biology
(R-MMU-1266738)
Ecm proteoglycans
(R-MMU-3000178)
Elastic fibre formation
(R-MMU-1566948)
Extracellular matrix organization
(R-MMU-1474244)
Grb2:sos provides linkage to mapk signaling for integrins
(R-MMU-354194)
Hemostasis
(R-MMU-109582)
Integrin cell surface interactions
(R-MMU-216083)
Integrin signaling
(R-MMU-354192)
L1cam interactions
(R-MMU-373760)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Molecules associated with elastic fibres
(R-MMU-2129379)
Nervous system development
(R-MMU-9675108)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
P130cas linkage to mapk signaling for integrins
(R-MMU-372708)
Pecam1 interactions
(R-MMU-210990)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Syndecan interactions
(R-MMU-3000170)
Tgf-beta receptor signaling activates smads
(R-MMU-2173789)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Activation of protein kinase activity
(GO:0032147)
Apolipoprotein a-i-mediated signaling pathway
(GO:0038027)
Apoptotic cell clearance
(GO:0043277)
C-x3-c chemokine binding
(GO:0019960)
Cell-matrix adhesion
(GO:0007160)
Cell-substrate adhesion
(GO:0031589)
Cell-substrate junction assembly
(GO:0007044)
Cell adhesion
(GO:0007155)
Cell adhesion mediated by integrin
(GO:0033627)
Cell adhesion molecule binding
(GO:0050839)
Cell migration
(GO:0016477)
Cell projection morphogenesis
(GO:0048858)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Enzyme binding
(GO:0019899)
Extracellular matrix binding
(GO:0050840)
Fibrinogen binding
(GO:0070051)
Fibroblast growth factor binding
(GO:0017134)
Fibronectin binding
(GO:0001968)
Heterotypic cell-cell adhesion
(GO:0034113)
Identical protein binding
(GO:0042802)
Insulin-like growth factor i binding
(GO:0031994)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Metal ion binding
(GO:0046872)
Negative chemotaxis
(GO:0050919)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of lipoprotein metabolic process
(GO:0050748)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Neuregulin binding
(GO:0038132)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Platelet activation
(GO:0030168)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of osteoblast proliferation
(GO:0033690)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein disulfide isomerase activity
(GO:0003756)
Protein kinase c binding
(GO:0005080)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of protein localization
(GO:0032880)
Regulation of release of sequestered calcium ion into cytosol
(GO:0051279)
Regulation of serotonin uptake
(GO:0051611)
Smooth muscle cell migration
(GO:0014909)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Symbiont entry into host cell
(GO:0046718)
Vascular endothelial growth factor receptor 2 binding
(GO:0043184)

Other Information

Proteins

ITB3_MOUSE

Genular Protein ID: 1580724236

Symbol: ITB3_MOUSE

Name: N/A

UniProtKB Accession Codes:

O54890 Q3TZC6

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11323698

Title: gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation.

PubMed ID: 11323698

DOI: 10.1038/87749

PubMed ID: 11805835

Title: Fibulin-5/DANCE is essential for elastogenesis in vivo.

PubMed ID: 11805835

DOI: 10.1038/415171a

PubMed ID: 12606711

Title: Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.

PubMed ID: 12606711

DOI: 10.1073/pnas.262791999

PubMed ID: 18483218

Title: Kindlin-2 controls bidirectional signaling of integrins.

PubMed ID: 18483218

DOI: 10.1101/gad.469408

PubMed ID: 18549786

Title: Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins.

PubMed ID: 18549786

DOI: 10.1016/j.neuron.2008.04.011

PubMed ID: 19332769

Title: Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

PubMed ID: 19332769

DOI: 10.1182/blood-2008-03-145821

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22492581

Title: DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway.

PubMed ID: 22492581

DOI: 10.1002/jbmr.1632

PubMed ID: 24935931

Title: gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells.

PubMed ID: 24935931

DOI: 10.4049/jimmunol.1302772

PubMed ID: 24429998

Title: Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling.

PubMed ID: 24429998

DOI: 10.1160/th13-09-0738

PubMed ID: 29038237

Title: The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

PubMed ID: 29038237

DOI: 10.1523/jneurosci.1482-17.2017

PubMed ID: 35687021

Title: PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.

PubMed ID: 35687021

DOI: 10.1083/jcb.202108027

Sequence Information:

Length: 787
Mass: 86738
Checksum: 4F2E606969788794
Sequence:

MRAQWPGQLW AALLALGALA GVVVGESNIC TTRGVNSCQQ CLAVSPVCAW CSDETLSQGS 
PRCNLKENLL KDNCAPESIE FPVSEAQILE ARPLSSKGSG SSAQITQVSP QRIALRLRPD 
DSKIFSLQVR QVEDYPVDIY YLMDLSFSMK DDLSSIQTLG TKLASQMRKL TSNLRIGFGA 
FVDKPVSPYM YISPPQAIKN PCYNMKNACL PMFGYKHVLT LTDQVSRFNE EVKKQSVSRN 
RDAPEGGFDA IMQATVCDEK IGWRNDASHL LVFTTDAKTH IALDGRLAGI VLPNDGHCHI 
GTDNHYSAST TMDYPSLGLM TEKLSQKNIN LIFAVTENVV SLYQNYSELI PGTTVGVLSD 
DSSNVLQLIV DAYGKIRSKV ELEVRDLPEE LSLSFNATCL NNEVIPGLKS CVGLKIGDTV 
SFSIEAKVRG CPQEKEQSFT IKPVGFKDSL TVQVTFDCDC ACQAFAQPSS PRCNNGNGTF 
ECGVCRCDQG WLGSMCECSE EDYRPSQQEE CSPKEGQPIC SQRGECLCGQ CVCHSSDFGK 
ITGKYCECDD FSCVRYKGEM CSGHGQCNCG DCVCDSDWTG YYCNCTTRTD TCMSTNGLLC 
SGRGNCECGS CVCVQPGSYG DTCEKCPTCP DACSFKKECV ECKKFNRGTL HEENTCSRYC 
RDDIEQVKEL TDTGKNAVNC TYKNEDDCVV RFQYYEDTSG RAVLYVVEEP ECPKGPDILV 
VLLSVMGAIL LIGLATLLIW KLLITIHDRK EFAKFEEERA RAKWDTANNP LYKEATSTFT 
NITYRGT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Itgb3

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. PubMed ID: 11323698

Fibulin-5/DANCE is essential for elastogenesis in vivo. PubMed ID: 11805835

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. PubMed ID: 12606711

Kindlin-2 controls bidirectional signaling of integrins. PubMed ID: 18483218

Activity-dependent regulation of synaptic AMPA receptor composition and abundance by beta3 integrins. PubMed ID: 18549786

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. PubMed ID: 19332769

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

DICAM inhibits osteoclast differentiation through attenuation of the integrin alphaVbeta3 pathway. PubMed ID: 22492581

gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. PubMed ID: 24935931

Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling. PubMed ID: 24429998

The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. PubMed ID: 29038237

PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins. PubMed ID: 35687021