Genular: Defining Cellular Identity and Function

Details for: Eif6

Gene ID: 16418

Symbol: Eif6

Ensembl ID: ENSMUSG00000027613

Description: eukaryotic translation initiation factor 6

Associated with

Assembly of large subunit precursor of preribosome
(GO:1902626)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Cytosolic ribosome assembly
(GO:0042256)
Intermediate filament
(GO:0005882)
Lamin filament
(GO:0005638)
Maturation of 5.8s rrna
(GO:0000460)
Maturation of lsu-rrna
(GO:0000470)
Mirna-mediated gene silencing by inhibition of translation
(GO:0035278)
Mirna-mediated post-transcriptional gene silencing
(GO:0035195)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of translation
(GO:0045727)
Preribosome, large subunit precursor
(GO:0030687)
Regulation of fatty acid biosynthetic process
(GO:0042304)
Regulation of glycolytic process
(GO:0006110)
Regulation of megakaryocyte differentiation
(GO:0045652)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to insulin
(GO:0032868)
Ribosomal large subunit binding
(GO:0043023)
Ribosomal subunit export from nucleus
(GO:0000054)
Ribosome binding
(GO:0043022)
Ribosome biogenesis
(GO:0042254)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)

Other Information

Proteins

B4 integrin interactor

Genular Protein ID: 949755787

Symbol: IF6_MOUSE

Name: B4 integrin interactor

UniProtKB Accession Codes:

O55135

Database IDs:

Citations:

PubMed ID: 10206977

Title: Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae.

PubMed ID: 10206977

DOI: 10.1074/jbc.274.17.11653

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9374518

Title: Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells.

PubMed ID: 9374518

DOI: 10.1074/jbc.272.48.30314

PubMed ID: 11290417

Title: The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo.

PubMed ID: 11290417

DOI: 10.1016/s0378-1119(01)00370-5

PubMed ID: 18784653

Title: Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.

PubMed ID: 18784653

DOI: 10.1038/nature07267

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21665150

Title: Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.

PubMed ID: 21665150

DOI: 10.1016/j.ccr.2011.04.018

PubMed ID: 21536732

Title: Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome.

PubMed ID: 21536732

DOI: 10.1101/gad.623011

PubMed ID: 26391622

Title: Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.

PubMed ID: 26391622

DOI: 10.1111/jth.13150

PubMed ID: 26383020

Title: eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.

PubMed ID: 26383020

DOI: 10.1038/ncomms9261

PubMed ID: 28575669

Title: The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity.

PubMed ID: 28575669

DOI: 10.1016/j.cell.2017.05.022

Sequence Information:

Length: 245
Mass: 26511
Checksum: 35BF0F4C17D5E045
Sequence:

MAVRASFENN CEVGCFAKLT NAYCLVAIGG SENFYSVFEG ELSDAIPVVH ASIAGCRIIG 
RMCVGNRHGL LVPNNTTDQE LQHIRNSLPD SVQIRRVEER LSALGNVTTC NDYVALVHPD 
LDRETEEILA DVLKVEVFRQ TVADQVLVGS YCVFSNQGGL VHPKTSIEDQ DELSSLLQVP 
LVAGTVNRGS EVIAAGMVVN DWCAFCGLDT TSTELSVVES VFKLNEAKPS TIATSMRDSL 
IDSLT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif6

Associated with

Other Information

Cloning of murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in Saccharomyces cerevisiae. PubMed ID: 10206977

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. PubMed ID: 9374518

The human ITGB4BP gene is constitutively expressed in vitro, but highly modulated in vivo. PubMed ID: 11290417

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. PubMed ID: 18784653

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth. PubMed ID: 21665150

Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome. PubMed ID: 21536732

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation. PubMed ID: 26391622

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription. PubMed ID: 26383020

The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity. PubMed ID: 28575669